DVL12_ARATH
ID DVL12_ARATH Reviewed; 54 AA.
AC Q6IM89;
DT 02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Small polypeptide DEVIL 12 {ECO:0000303|PubMed:14871303};
DE AltName: Full=Small polypeptide ROTUNDIFOLIA LIKE 22 {ECO:0000303|PubMed:15125775};
DE Short=Small polypeptide ROT-FOUR-LIKE 22 {ECO:0000303|PubMed:15125775};
GN Name=DVL12 {ECO:0000303|PubMed:14871303};
GN Synonyms=RTFL22 {ECO:0000303|PubMed:15125775};
GN OrderedLocusNames=At1g64585 {ECO:0000312|Araport:AT1G64585};
GN ORFNames=F1N19 {ECO:0000312|EMBL:AC009519};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=14871303; DOI=10.1111/j.1365-313x.2003.01994.x;
RA Wen J., Lease K.A., Walker J.C.;
RT "DVL, a novel class of small polypeptides: overexpression alters
RT Arabidopsis development.";
RL Plant J. 37:668-677(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY.
RC STRAIN=cv. Columbia, and cv. Landsberg erecta;
RX PubMed=15125775; DOI=10.1111/j.1365-313x.2004.02078.x;
RA Narita N.N., Moore S., Horiguchi G., Kubo M., Demura T., Fukuda H.,
RA Goodrich J., Tsukaya H.;
RT "Overexpression of a novel small peptide ROTUNDIFOLIA4 decreases cell
RT proliferation and alters leaf shape in Arabidopsis thaliana.";
RL Plant J. 38:699-713(2004).
RN [5]
RP REVIEW, GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=25701405; DOI=10.1007/s10265-015-0703-1;
RA Guo P., Yoshimura A., Ishikawa N., Yamaguchi T., Guo Y., Tsukaya H.;
RT "Comparative analysis of the RTFL peptide family on the control of plant
RT organogenesis.";
RL J. Plant Res. 128:497-510(2015).
CC -!- FUNCTION: Small polypeptide acting as a regulatory molecule which
CC coordinates cellular responses required for differentiation, growth and
CC development, probably by restricting polar cell proliferation in
CC lateral organs and coordinating socket cell recruitment and
CC differentiation at trichome sites. {ECO:0000250|UniProtKB:Q6X5V0}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q7XXN8};
CC Single-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the DVL/RTFL small polypeptides family.
CC {ECO:0000305}.
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DR EMBL; BK001755; DAA02283.1; -; Genomic_DNA.
DR EMBL; AC009519; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002684; AEE34257.1; -; Genomic_DNA.
DR RefSeq; NP_001077771.1; NM_001084302.1.
DR AlphaFoldDB; Q6IM89; -.
DR PaxDb; Q6IM89; -.
DR PRIDE; Q6IM89; -.
DR EnsemblPlants; AT1G64585.1; AT1G64585.1; AT1G64585.
DR GeneID; 5007834; -.
DR Gramene; AT1G64585.1; AT1G64585.1; AT1G64585.
DR KEGG; ath:AT1G64585; -.
DR Araport; AT1G64585; -.
DR TAIR; locus:4010713581; AT1G64585.
DR HOGENOM; CLU_150897_5_1_1; -.
DR InParanoid; Q6IM89; -.
DR OMA; CWREPRD; -.
DR OrthoDB; 1637761at2759; -.
DR PhylomeDB; Q6IM89; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q6IM89; baseline.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0048367; P:shoot system development; ISS:TAIR.
DR InterPro; IPR012552; DVL.
DR Pfam; PF08137; DVL; 1.
PE 3: Inferred from homology;
KW Cell membrane; Developmental protein; Glycoprotein; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..54
FT /note="Small polypeptide DEVIL 12"
FT /id="PRO_0000452780"
FT TRANSMEM 31..48
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 20..51
FT /note="Required for DVL/RTFL small polypeptide activity"
FT /evidence="ECO:0000250|UniProtKB:Q7XXN8"
FT CARBOHYD 26
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 54 AA; 6525 MW; F5253372AA0F9A93 CRC64;
MIVKLMGSNK DLHRQAKNNN NKLTPNRSLK ETRSRLYIIR RCLVMLLCWR EPRD
