ID   DVL16_ARATH             Reviewed;          53 AA.
AC   Q7XXN8;
DT   02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Small polypeptide DEVIL 16 {ECO:0000303|PubMed:14871303};
DE   AltName: Full=Small polypeptide ROTUNDIFOLIA 4 {ECO:0000303|PubMed:15125775};
DE            Short=Small polypeptide ROT-FOUR {ECO:0000303|PubMed:15125775};
GN   Name=DVL16 {ECO:0000303|PubMed:14871303};
GN   Synonyms=ROT4 {ECO:0000303|PubMed:15125775};
GN   OrderedLocusNames=At2g36985 {ECO:0000312|Araport:AT2G36985};
GN   ORFNames=T1J8 {ECO:0000312|EMBL:AC006922};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], GENE FAMILY, AND NOMENCLATURE.
RC   STRAIN=cv. Columbia;
RX   PubMed=14871303; DOI=10.1111/j.1365-313x.2003.01994.x;
RA   Wen J., Lease K.A., Walker J.C.;
RT   "DVL, a novel class of small polypeptides: overexpression alters
RT   Arabidopsis development.";
RL   Plant J. 37:668-677(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR
RP   LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION BY LIGHT, AND
RP   GENE FAMILY.
RC   STRAIN=cv. Columbia, and cv. Landsberg erecta;
RX   PubMed=15125775; DOI=10.1111/j.1365-313x.2004.02078.x;
RA   Narita N.N., Moore S., Horiguchi G., Kubo M., Demura T., Fukuda H.,
RA   Goodrich J., Tsukaya H.;
RT   "Overexpression of a novel small peptide ROTUNDIFOLIA4 decreases cell
RT   proliferation and alters leaf shape in Arabidopsis thaliana.";
RL   Plant J. 38:699-713(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   FUNCTION.
RC   STRAIN=cv. Columbia;
RX   DOI=10.1007/s11105-009-0131-2;
RA   Larue C.T., Wen J., Walker J.C.;
RT   "Interactions between a NAC-domain transcription factor and the putative
RT   small protein encoding DVL/ROT gene family.";
RL   Plant Mol. Biol. Rep. 28:162-168(2010).
RN   [7]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=20826883; DOI=10.1093/pcp/pcq138;
RA   Ikeuchi M., Yamaguchi T., Kazama T., Ito T., Horiguchi G., Tsukaya H.;
RT   "ROTUNDIFOLIA4 regulates cell proliferation along the body axis in
RT   Arabidopsis shoot.";
RL   Plant Cell Physiol. 52:59-69(2011).
RN   [8]
RP   FUNCTION, REVIEW, GENE FAMILY, AND NOMENCLATURE.
RC   STRAIN=cv. Columbia;
RX   PubMed=25701405; DOI=10.1007/s10265-015-0703-1;
RA   Guo P., Yoshimura A., Ishikawa N., Yamaguchi T., Guo Y., Tsukaya H.;
RT   "Comparative analysis of the RTFL peptide family on the control of plant
RT   organogenesis.";
RL   J. Plant Res. 128:497-510(2015).
CC   -!- FUNCTION: Small polypeptide acting as a regulatory molecule which
CC       coordinates cellular responses required for differentiation, growth and
CC       development, probably by restricting polar cell proliferation in
CC       lateral organs (e.g. leaves) and coordinating socket cell recruitment
CC       and differentiation at trichome sites (PubMed:15125775,
CC       PubMed:20826883, Ref.6, PubMed:25701405). Regulates the positional cue
CC       and cell proliferation along the body axis (PubMed:20826883).
CC       {ECO:0000269|PubMed:15125775, ECO:0000269|PubMed:20826883,
CC       ECO:0000269|PubMed:25701405, ECO:0000269|Ref.6}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15125775,
CC       ECO:0000269|PubMed:20826883}; Single-pass membrane protein
CC       {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Mostly expressed in stems, flower buds, flowers and
CC       seedling shoots, to a lesser extent, in roots and young cauline leaves,
CC       but not in mature rosette leaves (PubMed:15125775). Barely observed in
CC       cotyledons and leaf primordia (PubMed:15125775).
CC       {ECO:0000269|PubMed:15125775}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the shoot apex and young developing
CC       leaves (PubMed:15125775). In seedlings, present in the shoot apical
CC       meristem and throughout the lamina of young leaves primordia
CC       (PubMed:15125775). In cotyledons, stems and mature leaves, restricted
CC       to the vasculature (PubMed:15125775). Weakly expressed floral meristem
CC       primordia (PubMed:15125775). During flower development, first observed
CC       in the center of the floral meristem, in the L3 and underlying cells
CC       (PubMed:15125775). In floral buds, observed at low levels in the center
CC       of floral meristems and accumulates progressively in sepals, petals and
CC       in the center of developing stamens (PubMed:15125775). In mature
CC       flowers, confined to the vasculature of all floral organs
CC       (PubMed:15125775). {ECO:0000269|PubMed:15125775}.
CC   -!- INDUCTION: Accumulates in seedlings within 6 days after a shift from
CC       dark to light. {ECO:0000269|PubMed:15125775}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype.
CC       {ECO:0000269|PubMed:15125775}.
CC   -!- SIMILARITY: Belongs to the DVL/RTFL small polypeptides family.
CC       {ECO:0000305}.
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DR   EMBL; BK001759; DAA02287.1; -; Genomic_DNA.
DR   EMBL; AB107209; BAC78810.1; -; mRNA.
DR   EMBL; AC006922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002685; AEC09331.1; -; Genomic_DNA.
DR   EMBL; BT026004; ABG25093.1; -; mRNA.
DR   RefSeq; NP_973616.1; NM_201887.2.
DR   AlphaFoldDB; Q7XXN8; -.
DR   STRING; 3702.AT2G36985.1; -.
DR   PaxDb; Q7XXN8; -.
DR   PRIDE; Q7XXN8; -.
DR   EnsemblPlants; AT2G36985.1; AT2G36985.1; AT2G36985.
DR   GeneID; 2745585; -.
DR   Gramene; AT2G36985.1; AT2G36985.1; AT2G36985.
DR   KEGG; ath:AT2G36985; -.
DR   Araport; AT2G36985; -.
DR   TAIR; locus:1006230132; AT2G36985.
DR   eggNOG; ENOG502SA97; Eukaryota.
DR   HOGENOM; CLU_150897_4_2_1; -.
DR   InParanoid; Q7XXN8; -.
DR   OMA; FYIFRKC; -.
DR   OrthoDB; 1608021at2759; -.
DR   PhylomeDB; Q7XXN8; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q7XXN8; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IMP:UniProtKB.
DR   GO; GO:0042127; P:regulation of cell population proliferation; IMP:UniProtKB.
DR   GO; GO:0009416; P:response to light stimulus; IEP:UniProtKB.
DR   GO; GO:0048367; P:shoot system development; IMP:UniProtKB.
DR   InterPro; IPR012552; DVL.
DR   Pfam; PF08137; DVL; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Developmental protein; Glycoprotein; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..53
FT                   /note="Small polypeptide DEVIL 16"
FT                   /id="PRO_0000452784"
FT   TRANSMEM        30..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          14..45
FT                   /note="Required for DVL/RTFL small polypeptide activity"
FT                   /evidence="ECO:0000269|PubMed:15125775,
FT                   ECO:0000269|PubMed:20826883"
FT   CARBOHYD        6
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   53 AA;  6238 MW;  CAF10AA180D8891B CRC64;
     MAPEENGTCE PCKTFGQKCS HVVKKQRAKF YILRRCIAML VCWHDQNHDR KDS