ID   ADHR_DROLE              Reviewed;         269 AA.
AC   Q07587;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Alcohol dehydrogenase-related 31 kDa protein;
GN   Name=Adhr; Synonyms=Adh-dup;
OS   Drosophila lebanonensis (Fruit fly) (Scaptodrosophila lebanonensis).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Scaptodrosophila.
OX   NCBI_TaxID=7225;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8482531; DOI=10.1016/0378-1119(93)90364-9;
RA   Albalat R., Gonzalez-Duarte R.;
RT   "Adh and Adh-dup sequences of Drosophila lebanonensis and D. immigrans:
RT   interspecies comparisons.";
RL   Gene 126:171-178(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8028024; DOI=10.1007/bf00178845;
RA   Juan E., Papaceit M., Quintana A.;
RT   "Nucleotide sequence of the genomic region encompassing Adh and Adh-dup
RT   genes of D. lebanonensis (Scaptodrosophila): gene expression and
RT   evolutionary relationships.";
RL   J. Mol. Evol. 38:455-467(1994).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; M97637; AAA28356.1; -; Genomic_DNA.
DR   EMBL; X63716; CAA45249.1; -; Genomic_DNA.
DR   PIR; JN0565; JN0565.
DR   AlphaFoldDB; Q07587; -.
DR   SMR; Q07587; -.
DR   FlyBase; FBgn0012439; Dleb\Adhr.
DR   Proteomes; UP000504634; Unplaced.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002427; ADH-rel.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR01170; ADHRELATED.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..269
FT                   /note="Alcohol dehydrogenase-related 31 kDa protein"
FT                   /id="PRO_0000054506"
FT   ACT_SITE        152
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         11..34
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         139
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        265..269
FT                   /note="DKEDD -> TKRMIRQIRSFQKTIYI (in Ref. 2; CAA45249)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   269 AA;  29658 MW;  5206A5F06FE4F844 CRC64;
     MFDLTGKNVC YVADCGGIAL ETCKVLMTKN IAKLAILHSV ENPQAIAQLQ SLKPSTQIFF
     WTYDVTMARA DMQKYFDEVM VQMDYIDVLI YGATLCDETD IDGTINTNLT GMMNTCATVL
     PHMDKKKDGS GGLILNVTSV IGLDPSPVFC AYSASKFGVI GFTRSLADPL YYTQNGVAVM
     AVCCGPTKVF VDRELTAFLP YGQSFADRLR TAPCQSTAVC GQNIVRAIER GENGQIWIAD
     KGGLELVKLQ SYWHMADVFL HYMQDKEDD