ID   DVL18_ARATH             Reviewed;         144 AA.
AC   Q8LE84;
DT   02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Small polypeptide DEVIL 18 {ECO:0000303|PubMed:14871303};
DE   AltName: Full=Small polypeptide ROTUNDIFOLIA LIKE 5 {ECO:0000303|PubMed:15125775};
DE            Short=Small polypeptide ROT-FOUR-LIKE 5 {ECO:0000303|PubMed:15125775};
GN   Name=DVL18 {ECO:0000303|PubMed:14871303};
GN   Synonyms=RTFL5 {ECO:0000303|PubMed:15125775};
GN   OrderedLocusNames=At5g59510 {ECO:0000312|Araport:AT5G59510};
GN   ORFNames=F2O15.21 {ECO:0000312|EMBL:AED97199.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RC   STRAIN=cv. Columbia;
RX   PubMed=14871303; DOI=10.1111/j.1365-313x.2003.01994.x;
RA   Wen J., Lease K.A., Walker J.C.;
RT   "DVL, a novel class of small polypeptides: overexpression alters
RT   Arabidopsis development.";
RL   Plant J. 37:668-677(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RA   Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL   Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Kim C.J., Chen H., Shinn P., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   GENE FAMILY.
RC   STRAIN=cv. Columbia, and cv. Landsberg erecta;
RX   PubMed=15125775; DOI=10.1111/j.1365-313x.2004.02078.x;
RA   Narita N.N., Moore S., Horiguchi G., Kubo M., Demura T., Fukuda H.,
RA   Goodrich J., Tsukaya H.;
RT   "Overexpression of a novel small peptide ROTUNDIFOLIA4 decreases cell
RT   proliferation and alters leaf shape in Arabidopsis thaliana.";
RL   Plant J. 38:699-713(2004).
RN   [7]
RP   REVIEW, GENE FAMILY, AND NOMENCLATURE.
RC   STRAIN=cv. Columbia;
RX   PubMed=25701405; DOI=10.1007/s10265-015-0703-1;
RA   Guo P., Yoshimura A., Ishikawa N., Yamaguchi T., Guo Y., Tsukaya H.;
RT   "Comparative analysis of the RTFL peptide family on the control of plant
RT   organogenesis.";
RL   J. Plant Res. 128:497-510(2015).
CC   -!- FUNCTION: Small polypeptide acting as a regulatory molecule which
CC       coordinates cellular responses required for differentiation, growth and
CC       development, probably by restricting polar cell proliferation in
CC       lateral organs and coordinating socket cell recruitment and
CC       differentiation at trichome sites. {ECO:0000250|UniProtKB:Q6X5V0}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q7XXN8};
CC       Single-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the DVL/RTFL small polypeptides family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BK001761; DAA02289.1; -; mRNA.
DR   EMBL; AB025604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002688; AED97199.1; -; Genomic_DNA.
DR   EMBL; BT024678; ABD57503.1; -; mRNA.
DR   EMBL; AY085568; AAM62790.1; -; mRNA.
DR   RefSeq; NP_200759.2; NM_125343.3.
DR   AlphaFoldDB; Q8LE84; -.
DR   PaxDb; Q8LE84; -.
DR   PRIDE; Q8LE84; -.
DR   EnsemblPlants; AT5G59510.1; AT5G59510.1; AT5G59510.
DR   GeneID; 836070; -.
DR   Gramene; AT5G59510.1; AT5G59510.1; AT5G59510.
DR   KEGG; ath:AT5G59510; -.
DR   Araport; AT5G59510; -.
DR   TAIR; locus:2148388; AT5G59510.
DR   HOGENOM; CLU_150897_0_0_1; -.
DR   InParanoid; Q8LE84; -.
DR   OMA; CRNMAKE; -.
DR   OrthoDB; 1551698at2759; -.
DR   PhylomeDB; Q8LE84; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q8LE84; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; ISS:UniProtKB.
DR   GO; GO:0048367; P:shoot system development; ISS:TAIR.
DR   InterPro; IPR012552; DVL.
DR   Pfam; PF08137; DVL; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Developmental protein; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..144
FT                   /note="Small polypeptide DEVIL 18"
FT                   /id="PRO_0000452786"
FT   TRANSMEM        42..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          30..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          108..139
FT                   /note="Required for DVL/RTFL small polypeptide activity"
FT                   /evidence="ECO:0000250|UniProtKB:Q7XXN8"
SQ   SEQUENCE   144 AA;  16235 MW;  4A59FA973699222A CRC64;
     MDDENLWKVV KKDSIFETTH FSSKPVFTRS FSTKTSSSSS KPVFTRSFST KPTSYSSSEP
     IFRRSFSAKP TSSKSPFLSR SGSTKCPVDT SSTSKCSISR SLSQKGASVT RKCRNMAKEH
     KSRFYIMKRC VLMLVCWHKH ACDS