DVL1_ARATH
ID DVL1_ARATH Reviewed; 51 AA.
AC Q6X5V0;
DT 02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Small polypeptide DEVIL 1 {ECO:0000303|PubMed:14871303};
DE AltName: Full=Small polypeptide ROTUNDIFOLIA LIKE 18 {ECO:0000303|PubMed:15125775};
DE Short=Small polypeptide ROT-FOUR-LIKE 18 {ECO:0000303|PubMed:15125775};
GN Name=DVL1 {ECO:0000303|PubMed:14871303};
GN Synonyms=RTFL18 {ECO:0000303|PubMed:15125775};
GN OrderedLocusNames=At5g16023 {ECO:0000312|Araport:AT5G16023};
GN ORFNames=F1N13 {ECO:0000312|EMBL:AL391145};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, MUTAGENESIS OF ARG-23; TYR-37;
RP ILE-38; CYS-42 AND LEU-46, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, GENE
RP FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=14871303; DOI=10.1111/j.1365-313x.2003.01994.x;
RA Wen J., Lease K.A., Walker J.C.;
RT "DVL, a novel class of small polypeptides: overexpression alters
RT Arabidopsis development.";
RL Plant J. 37:668-677(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY.
RC STRAIN=cv. Columbia, and cv. Landsberg erecta;
RX PubMed=15125775; DOI=10.1111/j.1365-313x.2004.02078.x;
RA Narita N.N., Moore S., Horiguchi G., Kubo M., Demura T., Fukuda H.,
RA Goodrich J., Tsukaya H.;
RT "Overexpression of a novel small peptide ROTUNDIFOLIA4 decreases cell
RT proliferation and alters leaf shape in Arabidopsis thaliana.";
RL Plant J. 38:699-713(2004).
RN [5]
RP FUNCTION.
RC STRAIN=cv. Columbia;
RX PubMed=22112938; DOI=10.1093/jxb/err378;
RA Valdivia E.R., Chevalier D., Sampedro J., Taylor I., Niederhuth C.E.,
RA Walker J.C.;
RT "DVL genes play a role in the coordination of socket cell recruitment and
RT differentiation.";
RL J. Exp. Bot. 63:1405-1412(2012).
RN [6]
RP REVIEW, GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=25701405; DOI=10.1007/s10265-015-0703-1;
RA Guo P., Yoshimura A., Ishikawa N., Yamaguchi T., Guo Y., Tsukaya H.;
RT "Comparative analysis of the RTFL peptide family on the control of plant
RT organogenesis.";
RL J. Plant Res. 128:497-510(2015).
CC -!- FUNCTION: Small polypeptide acting as a regulatory molecule which
CC coordinates cellular responses required for differentiation, growth and
CC development, including leaves shape, pedicule elongation, inflorescence
CC organization and fruit maturation, probably by restricting polar cell
CC proliferation in lateral organs and coordinating socket cell
CC recruitment and differentiation at trichome sites.
CC {ECO:0000269|PubMed:14871303, ECO:0000269|PubMed:22112938}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q7XXN8};
CC Single-pass membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Mostly expressed in leaves and, to a lower extent,
CC in roots and stems. {ECO:0000269|PubMed:14871303}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype (PubMed:14871303). Impaired
CC developmental regulatory activity (PubMed:14871303).
CC {ECO:0000269|PubMed:14871303}.
CC -!- SIMILARITY: Belongs to the DVL/RTFL small polypeptides family.
CC {ECO:0000305}.
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DR EMBL; AY254203; AAP13816.1; -; mRNA.
DR EMBL; AL391145; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED92236.1; -; Genomic_DNA.
DR RefSeq; NP_001318571.1; NM_001343431.1.
DR AlphaFoldDB; Q6X5V0; -.
DR STRING; 3702.AT5G16023.1; -.
DR PaxDb; Q6X5V0; -.
DR PRIDE; Q6X5V0; -.
DR EnsemblPlants; AT5G16023.1; AT5G16023.1; AT5G16023.
DR GeneID; 28721166; -.
DR Gramene; AT5G16023.1; AT5G16023.1; AT5G16023.
DR KEGG; ath:AT5G16023; -.
DR Araport; AT5G16023; -.
DR TAIR; locus:4010713959; AT5G16023.
DR HOGENOM; CLU_150897_5_1_1; -.
DR InParanoid; Q6X5V0; -.
DR OMA; MKEQKGR; -.
DR PhylomeDB; Q6X5V0; -.
DR Proteomes; UP000006548; Chromosome 5.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0048367; P:shoot system development; IMP:TAIR.
DR GO; GO:0090437; P:socket cell differentiation; IMP:TAIR.
DR InterPro; IPR012552; DVL.
DR Pfam; PF08137; DVL; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Developmental protein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..51
FT /note="Small polypeptide DEVIL 1"
FT /id="PRO_0000452769"
FT TRANSMEM 28..44
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 20..51
FT /note="Required for DVL/RTFL small polypeptide activity"
FT /evidence="ECO:0000250|UniProtKB:Q7XXN8"
FT MUTAGEN 23
FT /note="R->E: Impaired developmental regulatory activity."
FT /evidence="ECO:0000269|PubMed:14871303"
FT MUTAGEN 37
FT /note="Y->N: Impaired developmental regulatory activity."
FT /evidence="ECO:0000269|PubMed:14871303"
FT MUTAGEN 38
FT /note="I->S: Impaired developmental regulatory activity."
FT /evidence="ECO:0000269|PubMed:14871303"
FT MUTAGEN 42
FT /note="C->S: Impaired developmental regulatory activity."
FT /evidence="ECO:0000269|PubMed:14871303"
FT MUTAGEN 46
FT /note="L->H: Impaired developmental regulatory activity."
FT /evidence="ECO:0000269|PubMed:14871303"
SQ SEQUENCE 51 AA; 6211 MW; F8FE224FDD24706C CRC64;
MEMKRVMMSS AERSKEKKRS ISRRLGKYMK EQKGRIYIIR RCMVMLLCSH D
