ID   DVL2_ARATH              Reviewed;          45 AA.
AC   Q6X5U1;
DT   02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Small polypeptide DEVIL 2 {ECO:0000303|PubMed:14871303};
DE   AltName: Full=Small polypeptide ROTUNDIFOLIA like 19 {ECO:0000303|PubMed:15125775};
DE            Short=Small polypeptide ROT-FOUR-LIKE 19 {ECO:0000303|PubMed:15125775};
GN   Name=DVL2 {ECO:0000303|PubMed:14871303};
GN   Synonyms=RTFL19 {ECO:0000303|PubMed:15125775};
GN   OrderedLocusNames=At3g02493 {ECO:0000312|Araport:AT3G02493};
GN   ORFNames=F16B3 {ECO:0000312|EMBL:AC021640};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, GENE FAMILY, AND
RP   NOMENCLATURE.
RC   STRAIN=cv. Columbia;
RX   PubMed=14871303; DOI=10.1111/j.1365-313x.2003.01994.x;
RA   Wen J., Lease K.A., Walker J.C.;
RT   "DVL, a novel class of small polypeptides: overexpression alters
RT   Arabidopsis development.";
RL   Plant J. 37:668-677(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   GENE FAMILY.
RC   STRAIN=cv. Columbia, and cv. Landsberg erecta;
RX   PubMed=15125775; DOI=10.1111/j.1365-313x.2004.02078.x;
RA   Narita N.N., Moore S., Horiguchi G., Kubo M., Demura T., Fukuda H.,
RA   Goodrich J., Tsukaya H.;
RT   "Overexpression of a novel small peptide ROTUNDIFOLIA4 decreases cell
RT   proliferation and alters leaf shape in Arabidopsis thaliana.";
RL   Plant J. 38:699-713(2004).
RN   [5]
RP   REVIEW, GENE FAMILY, AND NOMENCLATURE.
RC   STRAIN=cv. Columbia;
RX   PubMed=25701405; DOI=10.1007/s10265-015-0703-1;
RA   Guo P., Yoshimura A., Ishikawa N., Yamaguchi T., Guo Y., Tsukaya H.;
RT   "Comparative analysis of the RTFL peptide family on the control of plant
RT   organogenesis.";
RL   J. Plant Res. 128:497-510(2015).
CC   -!- FUNCTION: Small polypeptide acting as a regulatory molecule which
CC       coordinates cellular responses required for differentiation, growth and
CC       development, including leaves shape, pedicule elongation, inflorescence
CC       organization and fruit maturation, probably by restricting polar cell
CC       proliferation in lateral organs and coordinating socket cell
CC       recruitment and differentiation at trichome sites.
CC       {ECO:0000269|PubMed:14871303}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q7XXN8};
CC       Single-pass membrane protein {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Mostly expressed in stems and, to a lower extent,
CC       in roots and leaves. {ECO:0000269|PubMed:14871303}.
CC   -!- SIMILARITY: Belongs to the DVL/RTFL small polypeptides family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY254318; AAP13817.1; -; mRNA.
DR   EMBL; AC021640; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002686; AEE73818.1; -; Genomic_DNA.
DR   RefSeq; NP_001078094.1; NM_001084625.2.
DR   AlphaFoldDB; Q6X5U1; -.
DR   STRING; 3702.AT3G02493.1; -.
DR   PaxDb; Q6X5U1; -.
DR   PRIDE; Q6X5U1; -.
DR   EnsemblPlants; AT3G02493.1; AT3G02493.1; AT3G02493.
DR   GeneID; 5007978; -.
DR   Gramene; AT3G02493.1; AT3G02493.1; AT3G02493.
DR   KEGG; ath:AT3G02493; -.
DR   Araport; AT3G02493; -.
DR   TAIR; locus:4010713725; AT3G02493.
DR   HOGENOM; CLU_150897_5_1_1; -.
DR   InParanoid; Q6X5U1; -.
DR   OrthoDB; 1639820at2759; -.
DR   PhylomeDB; Q6X5U1; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; ISS:UniProtKB.
DR   GO; GO:0048367; P:shoot system development; IMP:TAIR.
DR   InterPro; IPR012552; DVL.
DR   Pfam; PF08137; DVL; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Developmental protein; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..45
FT                   /note="Small polypeptide DEVIL 2"
FT                   /id="PRO_0000452770"
FT   TRANSMEM        17..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          14..45
FT                   /note="Required for DVL/RTFL small polypeptide activity"
FT                   /evidence="ECO:0000250|UniProtKB:Q7XXN8"
SQ   SEQUENCE   45 AA;  5473 MW;  5374EF52FCA7AE50 CRC64;
     MESIMSLKRK EKKSQSRRLG KYLKEQKGRI YIIRRCVMML LCSHD