DVL3_XENTR
ID DVL3_XENTR Reviewed; 713 AA.
AC B1WAP7;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Segment polarity protein dishevelled homolog DVL-3 {ECO:0000250|UniProtKB:Q92997};
DE Short=Dishevelled-3 {ECO:0000250|UniProtKB:Q92997};
DE AltName: Full=DSH homolog 3;
GN Name=dvl3 {ECO:0000250|UniProtKB:Q92997};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000312|EMBL:AAI61453.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gastrula {ECO:0000312|EMBL:AAI61453.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the signal transduction pathway mediated by
CC multiple Wnt genes (By similarity). Required during ciliogenesis for
CC the docking of basal bodies to the apical plasma membrane (By
CC similarity). {ECO:0000250|UniProtKB:Q61062,
CC ECO:0000250|UniProtKB:Q6DKE2}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O14641}.
CC -!- SIMILARITY: Belongs to the DSH family. {ECO:0000255}.
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DR EMBL; BC161453; AAI61453.1; -; mRNA.
DR RefSeq; NP_001116929.1; NM_001123457.1.
DR AlphaFoldDB; B1WAP7; -.
DR SMR; B1WAP7; -.
DR STRING; 8364.ENSXETP00000037606; -.
DR PaxDb; B1WAP7; -.
DR Ensembl; ENSXETT00000037606; ENSXETP00000037606; ENSXETG00000017275.
DR GeneID; 100144702; -.
DR KEGG; xtr:100144702; -.
DR CTD; 1857; -.
DR Xenbase; XB-GENE-977362; dvl3.
DR eggNOG; KOG3571; Eukaryota.
DR HOGENOM; CLU_012601_1_0_1; -.
DR InParanoid; B1WAP7; -.
DR OrthoDB; 474724at2759; -.
DR Reactome; R-XTR-201688; WNT mediated activation of DVL.
DR Reactome; R-XTR-4086400; PCP/CE pathway.
DR Reactome; R-XTR-4641258; Degradation of DVL.
DR Reactome; R-XTR-4641262; Disassembly of the destruction complex and recruitment of AXIN to the membrane.
DR Reactome; R-XTR-5663220; RHO GTPases Activate Formins.
DR Proteomes; UP000008143; Chromosome 5.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000017275; Expressed in blastula and 12 other tissues.
DR ExpressionAtlas; B1WAP7; baseline.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0008013; F:beta-catenin binding; ISS:UniProtKB.
DR GO; GO:0005109; F:frizzled binding; IBA:GO_Central.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0032053; P:ciliary basal body organization; ISS:UniProtKB.
DR GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.40.240.130; -; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR024580; Dishevelled_C-dom.
DR InterPro; IPR008339; Dishevelled_fam.
DR InterPro; IPR003351; Dishevelled_protein_dom.
DR InterPro; IPR001158; DIX.
DR InterPro; IPR038207; DIX_dom_sf.
DR InterPro; IPR015506; Dsh/Dvl-rel.
DR InterPro; IPR008342; DVL3.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10878; PTHR10878; 1.
DR PANTHER; PTHR10878:SF6; PTHR10878:SF6; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF02377; Dishevelled; 1.
DR Pfam; PF00778; DIX; 1.
DR Pfam; PF12316; Dsh_C; 1.
DR Pfam; PF00595; PDZ; 1.
DR PRINTS; PR01760; DISHEVELLED.
DR SMART; SM00021; DAX; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50841; DIX; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 2: Evidence at transcript level;
KW Cilium biogenesis/degradation; Cytoplasm; Developmental protein;
KW Reference proteome; Wnt signaling pathway.
FT CHAIN 1..713
FT /note="Segment polarity protein dishevelled homolog DVL-3"
FT /id="PRO_0000354667"
FT DOMAIN 1..82
FT /note="DIX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00069"
FT DOMAIN 248..333
FT /note="PDZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT DOMAIN 421..495
FT /note="DEP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT REGION 87..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 545..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..171
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..226
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..577
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..593
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..632
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 713 AA; 78314 MW; E43625C6BC9E79A4 CRC64;
MGETKVIYHL DEQETPYLVK LPVPAEKVTL GDFKNVLNKP NYKFFFKSMD DDFGVVKEEI
SDDNAKLPCF NGRVVCWLVS ADGSQSDAGS VCADNQSDLP PPIERTGGIG DSRPPSFHPN
TRGSQENLDN ETETDSVVSA HRERPRRKET PEHATRLNGT SKMERRRDTG GYESSSTLMS
SELDSTSFFD SDEDDSTSRF SNSTEQSSAS RLMRRHKRRR RKPKAPRIER SSSFSSITDS
TMSLNIITVT LNMEKYNFLG ISIVGQSNER GDGGIYIGSI MKGGAVAADG RIEPGDMLLQ
VNDTNFENMS NDDAVRVLRE IVHKPGPITL TVAKCWDPSP RNCFTLPRSE PIRPIDPAAW
VSHTAAMTGS YPAYGMSPSM STITSTSSSI TSSIPETERF DDFQLSIHSD MVTIVKAMRS
PESGLEVRDR MWLKITIPNA FIGSDVVDWL YHHVEGFTDR REARKYASNL LKAGYIRHTV
NKITFSEQCY YIFGDLCGNM ANLSLNDHDG SSGTSDQDTL APLPHPGAAP WPIAFQYQYP
LPHPYSPHPG FPDPAYSYGG GSAGSQHSEG SRSSGSNRSS TEKRKEREAK GGDTKSGGSG
SESDHTTRSS VRRERAASER SVPASEHSHR SHHSIAHSIR SHHTHHSFGP PGIPPLYGAP
MMMMPAPASV IGPPGAPPSR DLASVPPELT ASRQSFRMAM GNPTKNSGVF DFL
