ADHR_DROME
ID ADHR_DROME Reviewed; 272 AA.
AC P91615; A4V0Q4; Q24230; Q6LAE8; Q9NKB9; Q9VJS2;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Alcohol dehydrogenase-related 31 kDa protein;
GN Name=Adhr; Synonyms=Adh-dup; ORFNames=CG3484;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1673107; DOI=10.1093/genetics/127.3.565;
RA Kreitman M., Hudson R.R.;
RT "Inferring the evolutionary histories of the Adh and Adh-dup loci in
RT Drosophila melanogaster from patterns of polymorphism and divergence.";
RL Genetics 127:565-582(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Canton-S;
RX PubMed=9155028; DOI=10.1093/emboj/16.8.2023;
RA Brogna S., Ashburner M.;
RT "The Adh-related gene of Drosophila melanogaster is expressed as a
RT functional dicistronic messenger RNA: multigenic transcription in higher
RT organisms.";
RL EMBO J. 16:2023-2031(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10471707; DOI=10.1093/genetics/153.1.179;
RA Ashburner M., Misra S., Roote J., Lewis S.E., Blazej R.G., Davis T.,
RA Doyle C., Galle R.F., George R.A., Harris N.L., Hartzell G., Harvey D.A.,
RA Hong L., Houston K.A., Hoskins R.A., Johnson G., Martin C., Moshrefi A.R.,
RA Palazzolo M., Reese M.G., Spradling A.C., Tsang G., Wan K.H., Whitelaw K.,
RA Celniker S.E., Rubin G.M.;
RT "An exploration of the sequence of a 2.9-Mb region of the genome of
RT Drosophila melanogaster: the Adh region.";
RL Genetics 153:179-219(1999).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-77.
RA Haymerle H.;
RL Thesis (1983), University of Cambridge, United Kingdom.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000305}.
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DR EMBL; X78384; CAA55152.1; -; Genomic_DNA.
DR EMBL; X98338; CAA66982.1; -; mRNA.
DR EMBL; AE014134; AAF53404.1; -; Genomic_DNA.
DR EMBL; AE014134; AAO41202.1; -; Genomic_DNA.
DR EMBL; Z00030; CAA77331.1; -; Genomic_DNA.
DR RefSeq; NP_001027272.1; NM_001032101.2.
DR RefSeq; NP_001285938.1; NM_001299009.1.
DR RefSeq; NP_477495.1; NM_058147.4.
DR AlphaFoldDB; P91615; -.
DR SMR; P91615; -.
DR DIP; DIP-21911N; -.
DR STRING; 7227.FBpp0099544; -.
DR PaxDb; P91615; -.
DR EnsemblMetazoa; FBtr0006151; FBpp0099544; FBgn0000056.
DR EnsemblMetazoa; FBtr0100187; FBpp0099545; FBgn0000056.
DR EnsemblMetazoa; FBtr0343699; FBpp0310282; FBgn0000056.
DR GeneID; 3772432; -.
DR KEGG; dme:Dmel_CG3484; -.
DR UCSC; CG3484-RA; d. melanogaster.
DR CTD; 3772432; -.
DR FlyBase; FBgn0000056; Adhr.
DR VEuPathDB; VectorBase:FBgn0000056; -.
DR eggNOG; KOG4169; Eukaryota.
DR HOGENOM; CLU_010194_2_16_1; -.
DR InParanoid; P91615; -.
DR OMA; TMAREDM; -.
DR PhylomeDB; P91615; -.
DR Reactome; R-DME-2453902; The canonical retinoid cycle in rods (twilight vision).
DR Reactome; R-DME-5365859; RA biosynthesis pathway.
DR BioGRID-ORCS; 3772432; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 3772432; -.
DR PRO; PR:P91615; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0000056; Expressed in Malpighian tubule and 21 other tissues.
DR Genevisible; P91615; DM.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR GO; GO:0016229; F:steroid dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0008202; P:steroid metabolic process; IBA:GO_Central.
DR InterPro; IPR002427; ADH-rel.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR01170; ADHRELATED.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; SSF51735; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 2: Evidence at transcript level;
KW Oxidoreductase; Reference proteome.
FT CHAIN 1..272
FT /note="Alcohol dehydrogenase-related 31 kDa protein"
FT /id="PRO_0000054509"
FT ACT_SITE 152
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT BINDING 11..34
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250"
FT BINDING 139
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT CONFLICT 127
FT /note="M -> I (in Ref. 1; CAA55152)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 272 AA; 30274 MW; 6FD2B13EEE2FAEA6 CRC64;
MFDLTGKHVC YVADCGGIAL ETSKVLMTKN IAKLAILQST ENPQAIAQLQ SIKPSTQIFF
WTYDVTMARE DMKKYFDEVM VQMDYIDVLI NGATLCDENN IDATINTNLT GMMNTVATVL
PYMDRKMGGT GGLIVNVTSV IGLDPSPVFC AYSASKFGVI GFTRSLADPL YYSQNGVAVM
AVCCGPTRVF VDRELKAFLE YGQSFADRLR RAPCQSTSVC GQNIVNAIER SENGQIWIAD
KGGLELVKLH WYWHMADQFV HYMQSNDEED QD
