DVR1_DANRE
ID DVR1_DANRE Reviewed; 355 AA.
AC P35621;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Protein DVR-1;
DE Flags: Precursor;
GN Name=dvr1; Synonyms=dvr-1, vg1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Embryo;
RX PubMed=8405668; DOI=10.1006/dbio.1993.1252;
RA Helde K.A., Grunwald D.J.;
RT "The DVR-1 (Vg1) transcript of zebrafish is maternally supplied and
RT distributed throughout the embryo.";
RL Dev. Biol. 159:418-426(1993).
CC -!- FUNCTION: Serves to facilitate the differentiation of either mesoderm
CC or endoderm either as a cofactor in an instructive signal or by
CC providing permissive environment.
CC -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Abundant in ovaries and eggs, and equally
CC distributed among all blastomeres.
CC -!- DEVELOPMENTAL STAGE: Concentrated in the streaming cytoplasm in just-
CC fertilized eggs. Evenly partitioned during cleavage among all
CC blastomeres. Absent in the yolk cell during cleavage, blastula and
CC gastrula stages. Distributed homogeneously among all cells of the
CC gastrula.
CC -!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
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DR EMBL; U00931; AAC27347.1; -; mRNA.
DR RefSeq; NP_571023.1; NM_130948.1.
DR AlphaFoldDB; P35621; -.
DR SMR; P35621; -.
DR STRING; 7955.ENSDARP00000055378; -.
DR PaxDb; P35621; -.
DR Ensembl; ENSDART00000055379; ENSDARP00000055378; ENSDARG00000037995.
DR GeneID; 30125; -.
DR KEGG; dre:30125; -.
DR CTD; 9573; -.
DR ZFIN; ZDB-GENE-980526-389; gdf3.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00940000164416; -.
DR HOGENOM; CLU_020515_4_0_1; -.
DR InParanoid; P35621; -.
DR OrthoDB; 919690at2759; -.
DR PhylomeDB; P35621; -.
DR TreeFam; TF351789; -.
DR PRO; PR:P35621; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 17.
DR Bgee; ENSDARG00000037995; Expressed in cleaving embryo and 32 other tissues.
DR ExpressionAtlas; P35621; baseline.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0032991; C:protein-containing complex; IPI:ZFIN.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0009798; P:axis specification; IMP:ZFIN.
DR GO; GO:0030509; P:BMP signaling pathway; IMP:ZFIN.
DR GO; GO:0060027; P:convergent extension involved in gastrulation; IMP:ZFIN.
DR GO; GO:0001947; P:heart looping; IMP:ZFIN.
DR GO; GO:0060972; P:left/right pattern formation; IMP:ZFIN.
DR GO; GO:0048666; P:neuron development; IMP:ZFIN.
DR GO; GO:0038092; P:nodal signaling pathway; IMP:ZFIN.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IBA:GO_Central.
DR GO; GO:1904086; P:regulation of epiboly involved in gastrulation with mouth forming second; IMP:CACAO.
DR GO; GO:1900145; P:regulation of nodal signaling pathway involved in determination of left/right asymmetry; IMP:ZFIN.
DR GO; GO:0060395; P:SMAD protein signal transduction; IBA:GO_Central.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848; PTHR11848; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW Growth factor; Mitogen; Reference proteome; Secreted; Signal.
FT SIGNAL 1..15
FT /evidence="ECO:0000255"
FT PROPEP 16..240
FT /evidence="ECO:0000255"
FT /id="PRO_0000033816"
FT CHAIN 241..355
FT /note="Protein DVR-1"
FT /id="PRO_0000033817"
FT CARBOHYD 108
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 179
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 296
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 254..320
FT /evidence="ECO:0000250"
FT DISULFID 283..352
FT /evidence="ECO:0000250"
FT DISULFID 287..354
FT /evidence="ECO:0000250"
FT DISULFID 319
FT /note="Interchain"
FT /evidence="ECO:0000250"
SQ SEQUENCE 355 AA; 40202 MW; 0ED5B9850EBFB222 CRC64;
MFLVLLRACL LTLSLCSPAE DDGLVQEKLF LSSMGLWSRP KPSHHAAVPS QMWKIFKQAS
KQTVNDPCVV SEYGVRGNIV RFMQDQGSLI SAPAVHSFNC VRKHLFFNMS VLEEVEQLSL
AQLEMKFKQD LLLLGPHVFS VDLYRVLKTT LKGVTHESSR KLLQSQTLSP GAHASVLVNL
TNLAQSWRKP EKNFGMQLEL QVMHLNNMLH DHAYVQIPDI HATLVVVSLN PLQCRSRRKR
SASYYLPVTP SNVCKPRRLY IDFKDVGWQD WIIAPQGYLA NYCHGECPFP LSESLNGTNH
AILQTLVHSF DPKGTPQPCC VPIKLSPISM LYYDNNDNVV LRHYEDMVVD ECGCR
