ID   DVR1_STRPU              Reviewed;         461 AA.
AC   P48969;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Protein DVR-1 homolog;
DE   Flags: Precursor;
GN   Name=DVR1;
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Ponce M.R., Micol J.L., Davidson E.H.;
RL   Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
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DR   EMBL; Z48313; CAA88306.1; -; mRNA.
DR   PIR; S52408; S52408.
DR   RefSeq; NP_999820.1; NM_214655.1.
DR   AlphaFoldDB; P48969; -.
DR   SMR; P48969; -.
DR   STRING; 7668.SPU_012786-tr; -.
DR   EnsemblMetazoa; NM_214655; NP_999820; GeneID_373534.
DR   GeneID; 373534; -.
DR   KEGG; spu:373534; -.
DR   CTD; 373534; -.
DR   eggNOG; KOG3900; Eukaryota.
DR   InParanoid; P48969; -.
DR   OMA; WLVNPEQ; -.
DR   OrthoDB; 1063560at2759; -.
DR   PhylomeDB; P48969; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030509; P:BMP signaling pathway; IBA:GO_Central.
DR   GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IBA:GO_Central.
DR   GO; GO:0060395; P:SMAD protein signal transduction; IBA:GO_Central.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR001111; TGF-b_propeptide.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR11848; PTHR11848; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   Pfam; PF00688; TGFb_propeptide; 1.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Cytokine; Disulfide bond; Glycoprotein;
KW   Growth factor; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   PROPEP          31..338
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000033818"
FT   CHAIN           339..461
FT                   /note="Protein DVR-1 homolog"
FT                   /id="PRO_0000033819"
FT   REGION          317..351
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        149
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        402
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        360..426
FT                   /evidence="ECO:0000250"
FT   DISULFID        389..458
FT                   /evidence="ECO:0000250"
FT   DISULFID        393..460
FT                   /evidence="ECO:0000250"
FT   DISULFID        425
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   461 AA;  51881 MW;  2573D54B6625F7EF CRC64;
     MEYSRKTYLD LNIMAKYILI LSLFFGPGLS WDVFYSGDED QLSLARERRA ANYNPSPHMS
     TWERNEIQQE ILNILGLQHR PRPPSLRGGQ NQFCAQFTEW SYYRTLNIDE QSGHPSETEP
     QPGGLASNAI YNSPDSSGIG SVMSGTVFNY TRNEVQAVSQ ADTIMSLPVH YKDAAIEDTE
     HRYRFDIGRI PQGETVTSAE LRVFRDAGRQ GRSLYRIDVL LLRERGSDGS RSPVYLDSTI
     VGAGDHGWLV FDMTSATSTW RSYPGANVGL QLRVESLQGL NIDPTDAGVV GVGNNEGREP
     FMVVFFQRNE EVIATNSHLR RNRRAATRQK KGGKRPRKPD TDNDIASRDS ASSLNSDWQC
     KRKNLFVNFE DLDWQEWIIA PLGYVAFYCQ GECAFPLNGH ANATNHAIVQ TLVHHMSPSH
     VPQPCCAPTK LSPITVLYYD DSRNVVLKKY KNMVVRACGC L