DVRA_ASPFU
ID DVRA_ASPFU Reviewed; 679 AA.
AC Q4WXK4;
DT 17-FEB-2016, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 2.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=C2H2 finger domain transcription factor dvrA {ECO:0000305};
GN Name=dvrA {ECO:0000303|PubMed:20675576}; ORFNames=AFUA_3G09820;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
RN [2]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=20675576; DOI=10.1128/ec.00055-10;
RA Ejzykowicz D.E., Solis N.V., Gravelat F.N., Chabot J., Li X.,
RA Sheppard D.C., Filler S.G.;
RT "Role of Aspergillus fumigatus DvrA in host cell interactions and
RT virulence.";
RL Eukaryot. Cell 9:1432-1440(2010).
RN [3]
RP INDUCTION.
RX PubMed=25534941; DOI=10.1128/iai.02685-14;
RA Pongpom M., Liu H., Xu W., Snarr B.D., Sheppard D.C., Mitchell A.P.,
RA Filler S.G.;
RT "Divergent targets of Aspergillus fumigatus AcuK and AcuM transcription
RT factors during growth in vitro versus invasive disease.";
RL Infect. Immun. 83:923-933(2015).
CC -!- FUNCTION: Transcription factor that seems to function as negative
CC regulators of virulence by affecting the capacity to damage host cells
CC and to stimulate a pro-inflammatory response.
CC {ECO:0000269|PubMed:20675576}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- INDUCTION: Expression is regulated by the AcuK and AcuM transcription
CC factors. {ECO:0000269|PubMed:25534941}.
CC -!- DISRUPTION PHENOTYPE: Results in increased resistance to the chitin
CC synthesis inhibitor nikkomycin Z and causes increased damage to
CC pulmonary epithelial cells and vascular endothelial cells, as well as
CC increased pulmonary epithelial cell cytokine gene expression.
CC {ECO:0000269|PubMed:20675576}.
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DR EMBL; AAHF01000002; EAL92599.2; -; Genomic_DNA.
DR RefSeq; XP_754637.2; XM_749544.2.
DR AlphaFoldDB; Q4WXK4; -.
DR SMR; Q4WXK4; -.
DR STRING; 746128.CADAFUBP00003854; -.
DR EnsemblFungi; EAL92599; EAL92599; AFUA_3G09820.
DR GeneID; 3512353; -.
DR KEGG; afm:AFUA_3G09820; -.
DR VEuPathDB; FungiDB:Afu3g09820; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_008830_0_0_1; -.
DR InParanoid; Q4WXK4; -.
DR OMA; SRSHSMY; -.
DR OrthoDB; 434252at2759; -.
DR PHI-base; PHI:2607; -.
DR Proteomes; UP000002530; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0052036; P:suppression by symbiont of host inflammatory response; IMP:AspGD.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 1.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 2: Evidence at transcript level;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Virulence; Zinc; Zinc-finger.
FT CHAIN 1..679
FT /note="C2H2 finger domain transcription factor dvrA"
FT /id="PRO_0000435646"
FT ZN_FING 109..134
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 140..162
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 531..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..98
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..551
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..591
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 679 AA; 73209 MW; 37596F992E56C1A3 CRC64;
MTSFLPVNNT SSPQTRPMEE VATAATPRPH TNVSATEENR SRTMNSGTED ATPLNLHKVQ
EDSASRTKPS LGHNGTSHGE SDADRDGSDH DSDAAGNAPP SKKKKGQRFY CTDFPPCNLS
FTRSEHLARH IRKHTGERPF QCHCSRRFSR LDNLRQHAQT VHVNEEIPGD SLAATGTRFQ
RQIRTDRVRP QGRARAGTGG SQGTHSRGHS RNLSTSSIAS TTSTYSQPPE LRRRPPPLIM
ANDGSARTRL GLDTMADIPT TPPGQVRGIP GPAVAVGSPY TPSHRLFAAG GNGSPHLASA
RPAAAHMSGF WDGKTAARRL SVPTSANPFA SQQPNNYPPS LVGSATPTTA AYPPGGVFAS
PVSSTHSFSR EENAYSAADA DLRRRTWHPS THFALPRPAT SGLSHYQTPD TVDAPVNASG
ATEQPPRLPG IESFDKVVLH QRPLTPPVRR PSPMQIDSHR KPSPSYALGG GFNYSQPANR
PAPPISGPGH RRGHVSWDMS LHTNLTGLHI RDKPLPRDAS HWSQQTIAEL QNVSSRPSSS
YQQQVQESRG ITGHSAYEKM QGWYGGHTSG SQATRTSPED SSSSEGVHTP STASLEYHPA
IVHNSGYIES HPPSMACDTS HSACPPLSQF SDGYQPHVKP DPRPDFYHNA SVRDSGMGRL
EALVAVATSE NKNTAKLYG
