DWORF_HUMAN
ID DWORF_HUMAN Reviewed; 35 AA.
AC P0DN84; A0A1B0GTW0;
DT 16-MAR-2016, integrated into UniProtKB/Swiss-Prot.
DT 03-JUL-2019, sequence version 2.
DT 03-AUG-2022, entry version 20.
DE RecName: Full=Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF {ECO:0000305};
DE Short=SERCA regulator DWORF {ECO:0000305};
DE AltName: Full=Dwarf open reading frame {ECO:0000303|PubMed:26816378};
DE Short=DWORF {ECO:0000303|PubMed:26816378};
DE AltName: Full=Small transmembrane regulator of ion transport 1 {ECO:0000312|HGNC:HGNC:52297};
GN Name=STRIT1 {ECO:0000312|HGNC:HGNC:52297};
GN Synonyms=DWORF {ECO:0000303|PubMed:26816378};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [2]
RP IDENTIFICATION.
RX PubMed=26816378; DOI=10.1126/science.aad4076;
RA Nelson B.R., Makarewich C.A., Anderson D.M., Winders B.R., Troupes C.D.,
RA Wu F., Reese A.L., McAnally J.R., Chen X., Kavalali E.T., Cannon S.C.,
RA Houser S.R., Bassel-Duby R., Olson E.N.;
RT "Muscle physiology. A peptide encoded by a transcript annotated as long
RT noncoding RNA enhances SERCA activity in muscle.";
RL Science 351:271-275(2016).
CC -!- FUNCTION: Enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic
CC reticulum by displacing ATP2A1/SERCA1 inhibitors, thereby acting as a
CC key regulator of skeletal muscle activity. Does not directly stimulate
CC SERCA pump activity. Enhances sarcoplasmic reticulum Ca(2+) uptake and
CC myocyte contractility by displacing the SERCA inhibitory peptides
CC sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN).
CC {ECO:0000250|UniProtKB:P0DN83}.
CC -!- SUBUNIT: Monomer. Interacts with ATP2A1/SERCA1.
CC {ECO:0000250|UniProtKB:P0DN83}.
CC -!- INTERACTION:
CC P0DN84; P16157-17: ANK1; NbExp=3; IntAct=EBI-12200293, EBI-941819;
CC P0DN84; Q68DC2: ANKS6; NbExp=3; IntAct=EBI-12200293, EBI-7054139;
CC P0DN84; A6NM10-2: AQP12B; NbExp=3; IntAct=EBI-12200293, EBI-17265552;
CC P0DN84; Q13520: AQP6; NbExp=3; IntAct=EBI-12200293, EBI-13059134;
CC P0DN84; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-12200293, EBI-11343438;
CC P0DN84; Q13323: BIK; NbExp=3; IntAct=EBI-12200293, EBI-700794;
CC P0DN84; J3KQ12: BSCL2; NbExp=5; IntAct=EBI-12200293, EBI-11532900;
CC P0DN84; Q7KYR7-4: BTN2A1; NbExp=3; IntAct=EBI-12200293, EBI-17841208;
CC P0DN84; P19397: CD53; NbExp=3; IntAct=EBI-12200293, EBI-6657396;
CC P0DN84; Q07108: CD69; NbExp=3; IntAct=EBI-12200293, EBI-2836595;
CC P0DN84; P11912: CD79A; NbExp=3; IntAct=EBI-12200293, EBI-7797864;
CC P0DN84; Q8TAZ6: CMTM2; NbExp=3; IntAct=EBI-12200293, EBI-2339374;
CC P0DN84; Q9HAV5: EDA2R; NbExp=3; IntAct=EBI-12200293, EBI-526033;
CC P0DN84; Q9Y624: F11R; NbExp=3; IntAct=EBI-12200293, EBI-742600;
CC P0DN84; O15552: FFAR2; NbExp=3; IntAct=EBI-12200293, EBI-2833872;
CC P0DN84; Q14802-3: FXYD3; NbExp=3; IntAct=EBI-12200293, EBI-12175685;
CC P0DN84; Q8NBJ4: GOLM1; NbExp=3; IntAct=EBI-12200293, EBI-712073;
CC P0DN84; O15529: GPR42; NbExp=3; IntAct=EBI-12200293, EBI-18076404;
CC P0DN84; Q9BZJ8: GPR61; NbExp=3; IntAct=EBI-12200293, EBI-12808020;
CC P0DN84; Q8NBQ5: HSD17B11; NbExp=3; IntAct=EBI-12200293, EBI-1052304;
CC P0DN84; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-12200293, EBI-18053395;
CC P0DN84; P38484: IFNGR2; NbExp=3; IntAct=EBI-12200293, EBI-3905457;
CC P0DN84; Q6UXK2: ISLR2; NbExp=3; IntAct=EBI-12200293, EBI-1266923;
CC P0DN84; Q9HDC5: JPH1; NbExp=3; IntAct=EBI-12200293, EBI-465137;
CC P0DN84; P48051: KCNJ6; NbExp=3; IntAct=EBI-12200293, EBI-12017638;
CC P0DN84; O95279: KCNK5; NbExp=3; IntAct=EBI-12200293, EBI-3934936;
CC P0DN84; Q9GZY8-5: MFF; NbExp=3; IntAct=EBI-12200293, EBI-11956541;
CC P0DN84; Q16653-13: MOG; NbExp=3; IntAct=EBI-12200293, EBI-24226707;
CC P0DN84; Q15800: MSMO1; NbExp=3; IntAct=EBI-12200293, EBI-949102;
CC P0DN84; Q9H2K0: MTIF3; NbExp=3; IntAct=EBI-12200293, EBI-3923617;
CC P0DN84; Q13113: PDZK1IP1; NbExp=3; IntAct=EBI-12200293, EBI-716063;
CC P0DN84; Q6UXB8: PI16; NbExp=3; IntAct=EBI-12200293, EBI-12810028;
CC P0DN84; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-12200293, EBI-17247926;
CC P0DN84; Q13336-2: SLC14A1; NbExp=3; IntAct=EBI-12200293, EBI-19141793;
CC P0DN84; O95436-2: SLC34A2; NbExp=3; IntAct=EBI-12200293, EBI-12811757;
CC P0DN84; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-12200293, EBI-17295964;
CC P0DN84; Q9H2H9: SLC38A1; NbExp=3; IntAct=EBI-12200293, EBI-9978441;
CC P0DN84; Q6ZMD2-2: SPNS3; NbExp=3; IntAct=EBI-12200293, EBI-17848320;
CC P0DN84; Q16623: STX1A; NbExp=3; IntAct=EBI-12200293, EBI-712466;
CC P0DN84; P32856-2: STX2; NbExp=3; IntAct=EBI-12200293, EBI-11956649;
CC P0DN84; Q96CE8: TM4SF18; NbExp=3; IntAct=EBI-12200293, EBI-13351685;
CC P0DN84; Q96IK0: TMEM101; NbExp=3; IntAct=EBI-12200293, EBI-3922699;
CC P0DN84; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-12200293, EBI-10982110;
CC P0DN84; Q9NW97: TMEM51; NbExp=3; IntAct=EBI-12200293, EBI-726044;
CC P0DN84; O95858: TSPAN15; NbExp=3; IntAct=EBI-12200293, EBI-7361096;
CC -!- SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:P0DN83}; Single-pass membrane protein
CC {ECO:0000255}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC104831; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS87158.1; -.
DR PDB; 7MPA; NMR; -; A=1-35.
DR PDBsum; 7MPA; -.
DR AlphaFoldDB; P0DN84; -.
DR SMR; P0DN84; -.
DR IntAct; P0DN84; 45.
DR TCDB; 1.A.50.4.1; the phospholamban (ca(2+)-channel and ca(2+)-atpase regulator) (plb) family.
DR BioMuta; -; -.
DR BioMuta; ENSG00000240045; -.
DR PeptideAtlas; P0DN84; -.
DR PRIDE; P0DN84; -.
DR Ensembl; ENST00000489090.2; ENSP00000489859.1; ENSG00000240045.2.
DR MANE-Select; ENST00000489090.2; ENSP00000489859.1; NM_001352129.2; NP_001339058.1.
DR GeneCards; STRIT1; -.
DR HGNC; HGNC:52297; STRIT1.
DR HPA; ENSG00000240045; Group enriched (skeletal muscle, tongue).
DR MIM; 616891; gene.
DR neXtProt; NX_P0DN84; -.
DR OpenTargets; ENSG00000240045; -.
DR VEuPathDB; HostDB:ENSG00000240045; -.
DR GeneTree; ENSGT00940000166505; -.
DR PathwayCommons; P0DN84; -.
DR SignaLink; P0DN84; -.
DR Pharos; P0DN84; Tdark.
DR PRO; PR:P0DN84; -.
DR Proteomes; UP000005640; Chromosome 3.
DR Bgee; ENSG00000240045; Expressed in gastrocnemius and 113 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0008047; F:enzyme activator activity; ISS:UniProtKB.
DR GO; GO:1902082; P:positive regulation of calcium ion import into sarcoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:1901894; P:regulation of ATPase-coupled calcium transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0031449; P:regulation of slow-twitch skeletal muscle fiber contraction; ISS:UniProtKB.
DR CDD; cd20247; DWORF; 1.
DR InterPro; IPR044529; DWORF.
PE 1: Evidence at protein level;
KW 3D-structure; Membrane; Reference proteome; Sarcoplasmic reticulum;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..35
FT /note="Sarcoplasmic/endoplasmic reticulum calcium ATPase
FT regulator DWORF"
FT /id="PRO_0000435802"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT HELIX 5..34
FT /evidence="ECO:0007829|PDB:7MPA"
SQ SEQUENCE 35 AA; 3836 MW; DD31615174585708 CRC64;
MAEKAGSTFS HLLVPILLLI GWIVGCIIMI YVVFS
