ID   ADHR_DROPE              Reviewed;         278 AA.
AC   O16091; O16092; O16094; O16096; P26621;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 3.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Alcohol dehydrogenase-related 31 kDa protein;
GN   Name=Adhr; Synonyms=Adh-dup;
OS   Drosophila persimilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7234;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Persimi40, Persimi42, Persimi44, Persimi49, and Persimi50;
RX   PubMed=9383055; DOI=10.1093/genetics/147.3.1091;
RA   Wang R.L., Wakeley J., Hey J.;
RT   "Gene flow and natural selection in the origin of Drosophila pseudoobscura
RT   and close relatives.";
RL   Genetics 147:1091-1106(1997).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; AF006564; AAB80703.1; -; Genomic_DNA.
DR   EMBL; AF006565; AAB80705.1; -; Genomic_DNA.
DR   EMBL; AF006566; AAB80707.1; -; Genomic_DNA.
DR   EMBL; AF006567; AAB80709.1; -; Genomic_DNA.
DR   EMBL; AF006568; AAB80711.1; -; Genomic_DNA.
DR   AlphaFoldDB; O16091; -.
DR   SMR; O16091; -.
DR   STRING; 7234.FBpp0190101; -.
DR   eggNOG; KOG4169; Eukaryota.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002427; ADH-rel.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR01170; ADHRELATED.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase.
FT   CHAIN           1..278
FT                   /note="Alcohol dehydrogenase-related 31 kDa protein"
FT                   /id="PRO_0000054510"
FT   ACT_SITE        152
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         11..34
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         139
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   VARIANT         200
FT                   /note="A -> E (in strain: Persimi42 and Persimi50)"
FT   VARIANT         204
FT                   /note="T -> S (in strain: Persimi42 and Persimi50)"
FT   VARIANT         222
FT                   /note="Q -> K (in strain: Persimi40 and Persimi42)"
SQ   SEQUENCE   278 AA;  30851 MW;  72195B6F261C2FBE CRC64;
     MYDLTGKHVC YVADCGGIAL ETSKVLMTKN IAKLAILQSV ENPPAIAQLQ SIKHSTQIFF
     WTFDVTMARE EMKKYFDEVM VQMDYIDVLI NGATLCDERN IDATINTNLT GMMNTVATVL
     PYMDRKMGGS GGLIVNVTSV IGLDPSPVFC AYSASKFGVI GFTRSLADPL YYTQNGVAVM
     AVCCGPTKVF VDRELTAFLA YGQTFADRLR RAPCQSTAVC GQNIVNAIER SENGQIWIAD
     KGGLESVALH WYWHMADQFV NYMQSTDDED QEFFLGQR