ID   ADHR_DROPS              Reviewed;         278 AA.
AC   P81764; B5DHK7; P26621; Q53WW1;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 2.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Alcohol dehydrogenase-related 31 kDa protein;
GN   Name=Adhr; Synonyms=Adh-dup; ORFNames=GA25223;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3666441; DOI=10.1093/genetics/117.1.61;
RA   Schaeffer S.W., Aquadro C.F.;
RT   "Nucleotide sequence of the Adh gene region of Drosophila pseudoobscura:
RT   evolutionary change and evidence for an ancient gene duplication.";
RL   Genetics 117:61-73(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PS271;
RX   PubMed=12688655; DOI=10.1017/s0016672302005955;
RA   Schaeffer S.W.;
RT   "Molecular population genetics of sequence length diversity in the Adh
RT   region of Drosophila pseudoobscura.";
RL   Genet. Res. 80:163-175(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; Y00602; CAA68646.1; -; Genomic_DNA.
DR   EMBL; U64535; AAL35977.1; -; Genomic_DNA.
DR   EMBL; CH379058; EDY69784.1; -; Genomic_DNA.
DR   PIR; S07246; S07246.
DR   RefSeq; XP_002132382.1; XM_002132346.2.
DR   AlphaFoldDB; P81764; -.
DR   SMR; P81764; -.
DR   STRING; 7237.FBpp0278980; -.
DR   EnsemblMetazoa; FBtr0280542; FBpp0278980; FBgn0012689.
DR   GeneID; 6903503; -.
DR   KEGG; dpo:Dpse_GA25223; -.
DR   eggNOG; KOG4169; Eukaryota.
DR   HOGENOM; CLU_010194_2_16_1; -.
DR   InParanoid; P81764; -.
DR   OMA; TMAREDM; -.
DR   Proteomes; UP000001819; Chromosome 4.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002427; ADH-rel.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR01170; ADHRELATED.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..278
FT                   /note="Alcohol dehydrogenase-related 31 kDa protein"
FT                   /id="PRO_0000054511"
FT   ACT_SITE        152
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         11..34
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         139
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        172
FT                   /note="F -> Y (in Ref. 1; CAA68646 and 2; AAL35977)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        200
FT                   /note="A -> E (in Ref. 1; CAA68646 and 2; AAL35977)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   278 AA;  30821 MW;  5E689483773250EF CRC64;
     MYDLTGKHVC YVADCGGIAL ETSKVLMTKN IAKLAILQSV ENPPAIAQLQ SIKHSTQIFF
     WTFDVTMARE EMKKYFDEVM VQMDYIDVLI NGATLCDERN IDATINTNLT GMMNTVATVL
     PYMDRKMGGS GGLIVNVTSV IGLDPSPVFC AYSASKFGVI GFTRSLADPL YFTQNGVAVM
     AVCCGPTKVF VDRELTAFLA YGQSFADRLR RAPCQSTAVC GQNIVNAIER SENGQIWIAD
     KGGLESVALH WYWHMADQFV NYMQSTDDED QEFFLGQR