ID   ADHR_DROSU              Reviewed;         279 AA.
AC   Q24640;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Alcohol dehydrogenase-related 31 kDa protein;
GN   Name=Adhr; Synonyms=Adh-dup;
OS   Drosophila subobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7241;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1560762; DOI=10.1093/oxfordjournals.molbev.a040718;
RA   Marfany G., Gonzalez-Duarte R.;
RT   "The Drosophila subobscura Adh genomic region contains valuable
RT   evolutionary markers.";
RL   Mol. Biol. Evol. 9:261-277(1992).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; M55545; AAA28340.1; -; Genomic_DNA.
DR   PIR; B42180; B42180.
DR   AlphaFoldDB; Q24640; -.
DR   SMR; Q24640; -.
DR   FlyBase; FBgn0012931; Dsub\Adhr.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002427; ADH-rel.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR01170; ADHRELATED.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase.
FT   CHAIN           1..279
FT                   /note="Alcohol dehydrogenase-related 31 kDa protein"
FT                   /id="PRO_0000054512"
FT   ACT_SITE        152
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         11..34
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         139
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   279 AA;  31078 MW;  7033F23D6F5F04F6 CRC64;
     MYDLTGKHVC YVADCGGIAL ETSKVLMTKN IAKLAILQSV ENQPAIARLQ SIKHSTQIFF
     WTFDVTMARQ EMKKYFDEVM VQMDYIDVLI NGATLCDERN IDATINTNLT GMMNTVATVL
     PYMDRKMGGS GGLIVNVTSV IGLDPSPVFC AYSASKFGVI GFTRSLADPL YYTQNGVAVM
     AVCCGPTKVF VDRELNAFLE YGQTFADRLR RAPCQSTAVC GQNIVTAIER SENGQIWIAD
     KGGLELLTLH WYWHMADQFL SYMQSTDDEN QEQFVSGQR