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ADH_DROGR
ID   ADH_DROGR               Reviewed;         254 AA.
AC   P51551; B4JRA5;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Alcohol dehydrogenase;
DE            EC=1.1.1.1;
GN   Name=Adh; ORFNames=GH13025;
OS   Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Hawaiian Drosophila.
OX   NCBI_TaxID=7222;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=G1;
RX   PubMed=8973307; DOI=10.1016/s0378-1119(96)00459-3;
RA   Brennan M.D., Thorpe P.A., Hu J., Dickinson W.J.;
RT   "Molecular organization of the alcohol dehydrogenase loci of Drosophila
RT   grimshawi and Drosophila hawaiiensis.";
RL   Gene 181:51-55(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15287-2541.00;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH;
CC         Xref=Rhea:RHEA:10736, ChEBI:CHEBI:15378, ChEBI:CHEBI:15734,
CC         ChEBI:CHEBI:17478, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.1;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10001};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a secondary alcohol + NAD(+) = a ketone + H(+) + NADH;
CC         Xref=Rhea:RHEA:10740, ChEBI:CHEBI:15378, ChEBI:CHEBI:17087,
CC         ChEBI:CHEBI:35681, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.1;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10001};
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; U48714; AAB40357.1; -; Genomic_DNA.
DR   EMBL; CH916372; EDV99435.1; -; Genomic_DNA.
DR   RefSeq; XP_001993510.1; XM_001993474.1.
DR   AlphaFoldDB; P51551; -.
DR   SMR; P51551; -.
DR   STRING; 7222.FBpp0146931; -.
DR   EnsemblMetazoa; FBtr0148439; FBpp0146931; FBgn0012316.
DR   GeneID; 6567072; -.
DR   KEGG; dgr:6567072; -.
DR   eggNOG; KOG4169; Eukaryota.
DR   HOGENOM; CLU_010194_2_16_1; -.
DR   InParanoid; P51551; -.
DR   OMA; TTLQCAQ; -.
DR   OrthoDB; 1053465at2759; -.
DR   PhylomeDB; P51551; -.
DR   ChiTaRS; Adh; fly.
DR   Proteomes; UP000001070; Unassembled WGS sequence.
DR   GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; ISS:UniProtKB.
DR   GO; GO:0006066; P:alcohol metabolic process; IEA:InterPro.
DR   InterPro; IPR002425; ADH_Drosophila-type.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR01168; ALCDHDRGNASE.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..254
FT                   /note="Alcohol dehydrogenase"
FT                   /id="PRO_0000054462"
FT   ACT_SITE        151
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         10..33
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         138
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   254 AA;  27417 MW;  2449DD6304777EC9 CRC64;
     MVIANSNIIF VAGLGGIGLD TSREIVKSGP KNLVVLDRVD NPAAIAELKA LNPKVTITFY
     PYDVTVPLAE TKKLLKTIFD KLKTVDLLIN GAGILDDNQI ERTIAVNFTG TVNTTTAILD
     FWDKRKGGPG GVVANICSVT GFNSIYQVPV YSASKAAALS FTTSIAKLAH ITGVTAYSIN
     PGITKTVLVH KFNSWLGVEP RVAELLLEHP TQTTLQCAQN FVKAIEANQN GAIWKLDLGR
     LDAIEWTKHW DSGI
 
 
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