DYAD_ARATH
ID DYAD_ARATH Reviewed; 639 AA.
AC Q9FGN8; Q946Y3;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 31-MAY-2011, sequence version 2.
DT 25-MAY-2022, entry version 100.
DE RecName: Full=Protein DYAD;
DE AltName: Full=Protein SWITCH 1;
GN Name=DYAD; Synonyms=SWI1; OrderedLocusNames=At5g51330; ORFNames=MFG13.3;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM L), FUNCTION, TISSUE SPECIFICITY, AND
RP SUBCELLULAR LOCATION.
RX PubMed=12135930; DOI=10.1242/dev.129.16.3935;
RA Agashe B., Prasad C.K., Siddiqi I.;
RT "Identification and analysis of DYAD: a gene required for meiotic
RT chromosome organisation and female meiotic progression in Arabidopsis.";
RL Development 129:3935-3943(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 4-639 (ISOFORMS L AND S), FUNCTION, TISSUE
RP SPECIFICITY, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RX PubMed=11459834; DOI=10.1101/gad.203201;
RA Mercier R., Vezon D., Bullier E., Motamayor J.C., Sellier A., Lefevre F.,
RA Pelletier G., Horlow C.;
RT "SWITCH1 (SWI1): a novel protein required for the establishment of sister
RT chromatid cohesion and for bivalent formation at meiosis.";
RL Genes Dev. 15:1859-1871(2001).
RN [5]
RP FUNCTION.
RX PubMed=10654613; DOI=10.1242/dev.127.1.197;
RA Siddiqi I., Ganesh G., Grossniklaus U., Subbiah V.;
RT "The dyad gene is required for progression through female meiosis in
RT Arabidopsis.";
RL Development 127:197-207(2000).
RN [6]
RP FUNCTION.
RX AGRICOLA=IND22037359; DOI=10.1007/s004970050002;
RA Motamayor J.C., Vezon D., Bajon C., Sauvanet A., Grandjean O., Marchand M.,
RA Bechtold N., Pelletier G., Horlow C.;
RT "Switch (swi1), an Arabidopsis thaliana mutant affected in the female
RT meiotic switch.";
RL Sex. Plant Reprod. 12:209-218(2000).
RN [7]
RP FUNCTION, TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=12783800; DOI=10.1242/dev.00550;
RA Mercier R., Armstrong S.J., Horlow C., Jackson N.P., Makaroff C.A.,
RA Vezon D., Pelletier G., Jones G.H., Franklin F.C.H.;
RT "The meiotic protein SWI1 is required for axial element formation and
RT recombination initiation in Arabidopsis.";
RL Development 130:3309-3318(2003).
RN [8]
RP FUNCTION.
RX PubMed=18272967; DOI=10.1038/nature06557;
RA Ravi M., Marimuthu M.P.A., Siddiqi I.;
RT "Gamete formation without meiosis in Arabidopsis.";
RL Nature 451:1121-1125(2008).
CC -!- FUNCTION: Required for fertility. Involved in chromatid cohesion
CC establishment, in chromosome structure during male and female meiosis
CC (e.g. the synapse formation between homologous chromosomes, the
CC recombination, and the cohesion of both chromatid arm and centromere),
CC and in axial element formation. Regulates the switch from mitosis to
CC the reductional meiosis division of megaspores prior to the female
CC gametogenesis (megasporogenesis). {ECO:0000269|PubMed:10654613,
CC ECO:0000269|PubMed:11459834, ECO:0000269|PubMed:12135930,
CC ECO:0000269|PubMed:12783800, ECO:0000269|PubMed:18272967,
CC ECO:0000269|Ref.6}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11459834,
CC ECO:0000269|PubMed:12135930, ECO:0000269|PubMed:12783800}.
CC Note=Localized in meiocyte nuclei just before meiosis, exclusively in
CC meiotic G1 and S phase (at protein level).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=L;
CC IsoId=Q9FGN8-1; Sequence=Displayed;
CC Name=S;
CC IsoId=Q9FGN8-2; Sequence=VSP_033111, VSP_033112;
CC -!- TISSUE SPECIFICITY: Meiocytes (at protein level).
CC {ECO:0000269|PubMed:11459834, ECO:0000269|PubMed:12135930,
CC ECO:0000269|PubMed:12783800}.
CC -!- DISRUPTION PHENOTYPE: Plants contain 2 cells with prominent nuclei in
CC the central region of the ovule where the embryo sac is normally
CC located. Sometimes, an unreduced diploid female gamete, arising from
CC apomeiosis, can be fertilized by a haploid male gamete, leading to a
CC viable triploid embryo. {ECO:0000269|PubMed:11459834}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL13233.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAB09744.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF466153; AAL73988.1; -; mRNA.
DR EMBL; AB025621; BAB09744.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED96067.1; -; Genomic_DNA.
DR EMBL; AF362001; AAL13232.1; -; mRNA.
DR EMBL; AF362002; AAL13233.1; ALT_FRAME; mRNA.
DR RefSeq; NP_001332209.1; NM_001344934.1.
DR RefSeq; NP_568757.2; NM_124512.3. [Q9FGN8-1]
DR AlphaFoldDB; Q9FGN8; -.
DR SMR; Q9FGN8; -.
DR STRING; 3702.AT5G51330.1; -.
DR PaxDb; Q9FGN8; -.
DR PRIDE; Q9FGN8; -.
DR EnsemblPlants; AT5G51330.1; AT5G51330.1; AT5G51330. [Q9FGN8-1]
DR GeneID; 835207; -.
DR Gramene; AT5G51330.1; AT5G51330.1; AT5G51330. [Q9FGN8-1]
DR KEGG; ath:AT5G51330; -.
DR Araport; AT5G51330; -.
DR TAIR; locus:2163645; AT5G51330.
DR eggNOG; ENOG502S3AA; Eukaryota.
DR HOGENOM; CLU_017061_1_0_1; -.
DR InParanoid; Q9FGN8; -.
DR OMA; LGWKIGD; -.
DR OrthoDB; 1270426at2759; -.
DR PRO; PR:Q9FGN8; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FGN8; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0007066; P:female meiosis sister chromatid cohesion; IMP:TAIR.
DR GO; GO:0007065; P:male meiosis sister chromatid cohesion; IMP:TAIR.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IMP:TAIR.
DR InterPro; IPR044221; DYAD/AMEIOTIC1.
DR PANTHER; PTHR46740; PTHR46740; 1.
DR PROSITE; PS50007; PIPLC_X_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Developmental protein; Meiosis; Nucleus;
KW Reference proteome.
FT CHAIN 1..639
FT /note="Protein DYAD"
FT /id="PRO_0000330766"
FT DOMAIN 351..498
FT /note="PI-PLC X-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00270"
FT REGION 201..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 536..561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..224
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..61
FT /note="Missing (in isoform S)"
FT /evidence="ECO:0000303|PubMed:11459834"
FT /id="VSP_033111"
FT VAR_SEQ 62..63
FT /note="VM -> MQ (in isoform S)"
FT /evidence="ECO:0000303|PubMed:11459834"
FT /id="VSP_033112"
SQ SEQUENCE 639 AA; 72731 MW; 44FDD6AAEE887FD7 CRC64;
MSSTMFVKRN PIRETTAGKI SSPSSPTLNV AVAHIRAGSY YEIDASILPQ RSPENLKSIR
VVMVSKITAS DVSLRYPSMF SLRSHFDYSR MNRNKPMKKR SGGGLLPVFD ESHVMASELA
GDLLYRRIAP HELSMNRNSW GFWVSSSSRR NKFPRREVVS QPAYNTRLCR AASPEGKCSS
ELKSGGMIKW GRRLRVQYQS RHIDTRKNKE GEESSRVKDE VYKEEEMEKE EDDDDGNEIG
GTKQEAKEIT NGNRKRKLIE SSTERLAQKA KVYDQKKETQ IVVYKRKSER KFIDRWSVER
YKLAERNMLK VMKEKNAVFG NSILRPELRS EARKLIGDTG LLDHLLKHMA GKVAPGGQDR
FMRKHNADGA MEYWLESSDL IHIRKEAGVK DPYWTPPPGW KLGDNPSQDP VCAGEIRDIR
EELASLKREL KKLASKKEEE ELVIMTTPNS CVTSQNDNLM TPAKEIYADL LKKKYKIEDQ
LVIIGETLRK MEEDMGWLKK TVDENYPKKP DSTETPLLLE DSPPIQTLEG EVKVVNKGNQ
ITESPQNREK GRKHDQQERS PLSLISNTGF RICRPVGMFA WPQLPALAAA TDTNASSPSH
RQAYPSPFPV KPLAAKRPLG LTFPFTIIPE EAPKNLFNV
