DYDC1_HUMAN
ID DYDC1_HUMAN Reviewed; 177 AA.
AC Q8WWB3; A8K927; Q5QP03; Q5QP04; Q6WNP4; Q6ZU87;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=DPY30 domain-containing protein 1;
GN Name=DYDC1; Synonyms=DPY30D1; ORFNames=RSD-9, RSD9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RA Tian X.Y., Qiao Y., Le X.N., Miao S.Y., Wang L.F.;
RT "A new spermatogenesis-related gene.";
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION, INTERACTION WITH SH3GL3, AND TISSUE SPECIFICITY.
RX PubMed=19545932; DOI=10.1016/j.ejcb.2009.05.001;
RA Li S., Qiao Y., Di Q., Le X., Zhang L., Zhang X., Zhang C., Cheng J.,
RA Zong S., Koide S.S., Miao S., Wang L.;
RT "Interaction of SH3P13 and DYDC1 protein: a germ cell component that
RT regulates acrosome biogenesis during spermiogenesis.";
RL Eur. J. Cell Biol. 88:509-520(2009).
CC -!- FUNCTION: Plays a crucial role during acrosome biogenesis.
CC {ECO:0000269|PubMed:19545932}.
CC -!- SUBUNIT: Interacts with SH3GL3. {ECO:0000269|PubMed:19545932}.
CC -!- INTERACTION:
CC Q8WWB3; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-740680, EBI-10175300;
CC Q8WWB3; P24863: CCNC; NbExp=3; IntAct=EBI-740680, EBI-395261;
CC Q8WWB3; Q8IYX8-2: CEP57L1; NbExp=3; IntAct=EBI-740680, EBI-10181988;
CC Q8WWB3; Q9C005: DPY30; NbExp=4; IntAct=EBI-740680, EBI-744973;
CC Q8WWB3; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-740680, EBI-744099;
CC Q8WWB3; P56524-2: HDAC4; NbExp=3; IntAct=EBI-740680, EBI-11953488;
CC Q8WWB3; A0A0S2Z4Q4: HGS; NbExp=3; IntAct=EBI-740680, EBI-16429135;
CC Q8WWB3; O14964: HGS; NbExp=3; IntAct=EBI-740680, EBI-740220;
CC Q8WWB3; O95678: KRT75; NbExp=3; IntAct=EBI-740680, EBI-2949715;
CC Q8WWB3; P25791-3: LMO2; NbExp=3; IntAct=EBI-740680, EBI-11959475;
CC Q8WWB3; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-740680, EBI-739832;
CC Q8WWB3; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-740680, EBI-10172526;
CC Q8WWB3; P00540: MOS; NbExp=3; IntAct=EBI-740680, EBI-1757866;
CC Q8WWB3; P56597: NME5; NbExp=8; IntAct=EBI-740680, EBI-740667;
CC Q8WWB3; Q17RL8: PDZD4; NbExp=3; IntAct=EBI-740680, EBI-10239064;
CC Q8WWB3; O00459: PIK3R2; NbExp=3; IntAct=EBI-740680, EBI-346930;
CC Q8WWB3; Q16512: PKN1; NbExp=3; IntAct=EBI-740680, EBI-602382;
CC Q8WWB3; P78424: POU6F2; NbExp=3; IntAct=EBI-740680, EBI-12029004;
CC Q8WWB3; Q14738: PPP2R5D; NbExp=3; IntAct=EBI-740680, EBI-396563;
CC Q8WWB3; P25786: PSMA1; NbExp=3; IntAct=EBI-740680, EBI-359352;
CC Q8WWB3; Q9BT92: TCHP; NbExp=6; IntAct=EBI-740680, EBI-740781;
CC Q8WWB3; Q15561: TEAD4; NbExp=3; IntAct=EBI-740680, EBI-747736;
CC Q8WWB3; P0C1Z6-2: TFPT; NbExp=3; IntAct=EBI-740680, EBI-10178002;
CC Q8WWB3; Q08117-2: TLE5; NbExp=3; IntAct=EBI-740680, EBI-11741437;
CC Q8WWB3; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-740680, EBI-10241197;
CC Q8WWB3; Q8N3L3: TXLNB; NbExp=6; IntAct=EBI-740680, EBI-6116822;
CC Q8WWB3; O14530: TXNDC9; NbExp=3; IntAct=EBI-740680, EBI-707554;
CC Q8WWB3; Q8N6Y0: USHBP1; NbExp=7; IntAct=EBI-740680, EBI-739895;
CC Q8WWB3; O75604: USP2; NbExp=3; IntAct=EBI-740680, EBI-743272;
CC Q8WWB3; A5D8V6: VPS37C; NbExp=3; IntAct=EBI-740680, EBI-2559305;
CC Q8WWB3; Q9Y2B5: VPS9D1; NbExp=3; IntAct=EBI-740680, EBI-9031083;
CC Q8WWB3; Q9BTA9: WAC; NbExp=3; IntAct=EBI-740680, EBI-749118;
CC Q8WWB3; Q8N5A5: ZGPAT; NbExp=3; IntAct=EBI-740680, EBI-3439227;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8WWB3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WWB3-2; Sequence=VSP_056983;
CC -!- TISSUE SPECIFICITY: Brain and testis. Accumulates during late stage of
CC spermiogenesis. {ECO:0000269|PubMed:19545932}.
CC -!- SIMILARITY: Belongs to the dpy-30 family. {ECO:0000305}.
CC -!- CAUTION: Sequence AAQ84766 was incorrectly indicated as originating
CC from mouse. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC86339.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
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DR EMBL; AY278322; AAQ84766.1; -; mRNA.
DR EMBL; AK125908; BAC86339.1; ALT_SEQ; mRNA.
DR EMBL; AK292542; BAF85231.1; -; mRNA.
DR EMBL; AL359195; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC019250; AAH19250.1; -; mRNA.
DR CCDS; CCDS7366.1; -. [Q8WWB3-1]
DR RefSeq; NP_001255982.1; NM_001269053.1. [Q8WWB3-1]
DR RefSeq; NP_620167.1; NM_138812.3. [Q8WWB3-1]
DR RefSeq; XP_005269606.1; XM_005269549.4. [Q8WWB3-2]
DR RefSeq; XP_005269607.1; XM_005269550.4. [Q8WWB3-2]
DR RefSeq; XP_011537636.1; XM_011539334.2. [Q8WWB3-2]
DR RefSeq; XP_011537637.1; XM_011539335.1. [Q8WWB3-1]
DR AlphaFoldDB; Q8WWB3; -.
DR SMR; Q8WWB3; -.
DR BioGRID; 126791; 40.
DR IntAct; Q8WWB3; 34.
DR STRING; 9606.ENSP00000361278; -.
DR PhosphoSitePlus; Q8WWB3; -.
DR BioMuta; DYDC1; -.
DR DMDM; 74751572; -.
DR MassIVE; Q8WWB3; -.
DR PaxDb; Q8WWB3; -.
DR PeptideAtlas; Q8WWB3; -.
DR PRIDE; Q8WWB3; -.
DR ProteomicsDB; 1890; -.
DR ProteomicsDB; 74872; -. [Q8WWB3-1]
DR Antibodypedia; 29980; 184 antibodies from 29 providers.
DR DNASU; 143241; -.
DR Ensembl; ENST00000372202.6; ENSP00000361276.1; ENSG00000170788.14. [Q8WWB3-1]
DR Ensembl; ENST00000372204.7; ENSP00000361278.3; ENSG00000170788.14. [Q8WWB3-1]
DR Ensembl; ENST00000421924.6; ENSP00000402890.3; ENSG00000170788.14. [Q8WWB3-1]
DR GeneID; 143241; -.
DR KEGG; hsa:143241; -.
DR MANE-Select; ENST00000372202.6; ENSP00000361276.1; NM_001269053.2; NP_001255982.1.
DR UCSC; uc001kbx.6; human. [Q8WWB3-1]
DR CTD; 143241; -.
DR DisGeNET; 143241; -.
DR GeneCards; DYDC1; -.
DR HGNC; HGNC:23460; DYDC1.
DR HPA; ENSG00000170788; Tissue enriched (testis).
DR MIM; 615154; gene.
DR neXtProt; NX_Q8WWB3; -.
DR OpenTargets; ENSG00000170788; -.
DR PharmGKB; PA134972260; -.
DR VEuPathDB; HostDB:ENSG00000170788; -.
DR eggNOG; ENOG502S3U3; Eukaryota.
DR GeneTree; ENSGT00940000161631; -.
DR HOGENOM; CLU_117703_1_0_1; -.
DR InParanoid; Q8WWB3; -.
DR OMA; GTCLIQG; -.
DR OrthoDB; 1628564at2759; -.
DR PhylomeDB; Q8WWB3; -.
DR TreeFam; TF330747; -.
DR PathwayCommons; Q8WWB3; -.
DR SignaLink; Q8WWB3; -.
DR SIGNOR; Q8WWB3; -.
DR BioGRID-ORCS; 143241; 32 hits in 1056 CRISPR screens.
DR ChiTaRS; DYDC1; human.
DR GenomeRNAi; 143241; -.
DR Pharos; Q8WWB3; Tdark.
DR PRO; PR:Q8WWB3; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q8WWB3; protein.
DR Bgee; ENSG00000170788; Expressed in left testis and 67 other tissues.
DR ExpressionAtlas; Q8WWB3; baseline and differential.
DR Genevisible; Q8WWB3; HS.
DR GO; GO:0044666; C:MLL3/4 complex; IEA:InterPro.
DR GO; GO:0048188; C:Set1C/COMPASS complex; IBA:GO_Central.
DR GO; GO:0051568; P:histone H3-K4 methylation; IBA:GO_Central.
DR InterPro; IPR007858; Dpy-30_motif.
DR InterPro; IPR037856; Sdc1/DPY30.
DR PANTHER; PTHR23356; PTHR23356; 1.
DR Pfam; PF05186; Dpy-30; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..177
FT /note="DPY30 domain-containing protein 1"
FT /id="PRO_0000247556"
FT VAR_SEQ 169..177
FT /note="IALNIDQDL -> VSISVFCEKTRFCFCF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056983"
SQ SEQUENCE 177 AA; 20893 MW; FB3DA4290972C623 CRC64;
MESIYLQKHL GACLTQGLAE VARVRPVDPI EYLALWIYKY KENVTMEQLR QKEMAKLERE
RELALMEQEM MERLKAEELL LQQQQLALQL ELEMQEKERQ RIQELQRAQE QLGKEMRMNM
ENLVRNEDIL HSEEATLDSG KTLAEISDRY GAPNLSRVEE LDEPMFSDIA LNIDQDL
