DYDC1_MOUSE
ID DYDC1_MOUSE Reviewed; 175 AA.
AC Q9D9T0; G3X8U6; Q810Q6;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=DPY30 domain-containing protein 1;
GN Name=Dydc1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION.
RX PubMed=19545932; DOI=10.1016/j.ejcb.2009.05.001;
RA Li S., Qiao Y., Di Q., Le X., Zhang L., Zhang X., Zhang C., Cheng J.,
RA Zong S., Koide S.S., Miao S., Wang L.;
RT "Interaction of SH3P13 and DYDC1 protein: a germ cell component that
RT regulates acrosome biogenesis during spermiogenesis.";
RL Eur. J. Cell Biol. 88:509-520(2009).
CC -!- FUNCTION: Plays a crucial role during acrosome biogenesis.
CC {ECO:0000269|PubMed:19545932}.
CC -!- SUBUNIT: Interacts with SH3GL3. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D9T0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D9T0-2; Sequence=VSP_020012;
CC -!- SIMILARITY: Belongs to the dpy-30 family. {ECO:0000305}.
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DR EMBL; AK006511; BAB24626.1; -; mRNA.
DR EMBL; AC154597; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466573; EDL24916.1; -; Genomic_DNA.
DR EMBL; BC049632; AAH49632.1; -; mRNA.
DR CCDS; CCDS49451.1; -. [Q9D9T0-1]
DR RefSeq; NP_081370.1; NM_027094.1. [Q9D9T0-1]
DR AlphaFoldDB; Q9D9T0; -.
DR SMR; Q9D9T0; -.
DR BioGRID; 213484; 2.
DR STRING; 10090.ENSMUSP00000124785; -.
DR iPTMnet; Q9D9T0; -.
DR PhosphoSitePlus; Q9D9T0; -.
DR PaxDb; Q9D9T0; -.
DR PRIDE; Q9D9T0; -.
DR ProteomicsDB; 279586; -. [Q9D9T0-1]
DR ProteomicsDB; 279587; -. [Q9D9T0-2]
DR Antibodypedia; 29980; 184 antibodies from 29 providers.
DR Ensembl; ENSMUST00000022315; ENSMUSP00000022315; ENSMUSG00000021790. [Q9D9T0-1]
DR Ensembl; ENSMUST00000189865; ENSMUSP00000139412; ENSMUSG00000021790. [Q9D9T0-1]
DR GeneID; 69496; -.
DR KEGG; mmu:69496; -.
DR UCSC; uc007tcl.2; mouse. [Q9D9T0-1]
DR CTD; 143241; -.
DR MGI; MGI:1916746; Dydc1.
DR VEuPathDB; HostDB:ENSMUSG00000021790; -.
DR eggNOG; ENOG502S3U3; Eukaryota.
DR GeneTree; ENSGT00940000161631; -.
DR InParanoid; Q9D9T0; -.
DR BioGRID-ORCS; 69496; 3 hits in 71 CRISPR screens.
DR PRO; PR:Q9D9T0; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q9D9T0; protein.
DR Bgee; ENSMUSG00000021790; Expressed in spermatid and 17 other tissues.
DR ExpressionAtlas; Q9D9T0; baseline and differential.
DR Genevisible; Q9D9T0; MM.
DR GO; GO:0044666; C:MLL3/4 complex; IEA:InterPro.
DR GO; GO:0048188; C:Set1C/COMPASS complex; IBA:GO_Central.
DR GO; GO:0051568; P:histone H3-K4 methylation; IBA:GO_Central.
DR InterPro; IPR007858; Dpy-30_motif.
DR InterPro; IPR037856; Sdc1/DPY30.
DR PANTHER; PTHR23356; PTHR23356; 1.
DR Pfam; PF05186; Dpy-30; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..175
FT /note="DPY30 domain-containing protein 1"
FT /id="PRO_0000247557"
FT REGION 94..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 152..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..109
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 69..84
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_020012"
FT CONFLICT 152
FT /note="A -> E (in Ref. 1; BAB24626)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 175 AA; 20494 MW; 45EAB6A38F877069 CRC64;
MESRYLQKCL GTCLTQGLTE VARVRPLDPI EYLAFWLYKH KENMNMEQMR QREMITLEHE
RELAMMEQEM LERLKAEELL FQQQLAFQLE LEMQQKEKQK SEDFETGQEK SFKSMMSMES
TARGEEQEPM QAEELVMDSG KTLAEISDRY GAPNLSRVEE LDEPMLSDNG VSAPP
