ID   DYDC2_HUMAN             Reviewed;         177 AA.
AC   Q96IM9; D3DWD6; Q5QP07; Q5QP11;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=DPY30 domain-containing protein 2;
GN   Name=DYDC2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q96IM9; Q9C005: DPY30; NbExp=3; IntAct=EBI-749277, EBI-744973;
CC       Q96IM9; P56597: NME5; NbExp=3; IntAct=EBI-749277, EBI-740667;
CC       Q96IM9; O95602: POLR1A; NbExp=3; IntAct=EBI-749277, EBI-359472;
CC       Q96IM9; Q8NEK8: TENT5D; NbExp=3; IntAct=EBI-749277, EBI-744726;
CC       Q96IM9; P68543: UBXN2A; NbExp=3; IntAct=EBI-749277, EBI-1993668;
CC   -!- SIMILARITY: Belongs to the dpy-30 family. {ECO:0000305}.
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DR   EMBL; AK093378; BAC04148.1; -; mRNA.
DR   EMBL; AL359195; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471142; EAW80391.1; -; Genomic_DNA.
DR   EMBL; CH471142; EAW80392.1; -; Genomic_DNA.
DR   EMBL; BC007374; AAH07374.1; -; mRNA.
DR   CCDS; CCDS7367.1; -.
DR   RefSeq; NP_001256970.1; NM_001270041.1.
DR   RefSeq; NP_115748.1; NM_032372.5.
DR   RefSeq; XP_011538569.1; XM_011540267.2.
DR   RefSeq; XP_011538570.1; XM_011540268.1.
DR   AlphaFoldDB; Q96IM9; -.
DR   SMR; Q96IM9; -.
DR   BioGRID; 124056; 11.
DR   IntAct; Q96IM9; 5.
DR   STRING; 9606.ENSP00000361272; -.
DR   iPTMnet; Q96IM9; -.
DR   PhosphoSitePlus; Q96IM9; -.
DR   BioMuta; DYDC2; -.
DR   DMDM; 74751940; -.
DR   jPOST; Q96IM9; -.
DR   MassIVE; Q96IM9; -.
DR   PaxDb; Q96IM9; -.
DR   PeptideAtlas; Q96IM9; -.
DR   PRIDE; Q96IM9; -.
DR   ProteomicsDB; 76840; -.
DR   Antibodypedia; 29986; 153 antibodies from 19 providers.
DR   DNASU; 84332; -.
DR   Ensembl; ENST00000256039.3; ENSP00000256039.2; ENSG00000133665.13.
DR   Ensembl; ENST00000372197.5; ENSP00000361271.1; ENSG00000133665.13.
DR   Ensembl; ENST00000372199.5; ENSP00000361273.1; ENSG00000133665.13.
DR   Ensembl; ENST00000444807.6; ENSP00000410285.2; ENSG00000133665.13.
DR   Ensembl; ENST00000616870.4; ENSP00000483479.1; ENSG00000133665.13.
DR   GeneID; 84332; -.
DR   KEGG; hsa:84332; -.
DR   MANE-Select; ENST00000256039.3; ENSP00000256039.2; NM_032372.6; NP_115748.1.
DR   UCSC; uc001kbz.4; human.
DR   CTD; 84332; -.
DR   DisGeNET; 84332; -.
DR   GeneCards; DYDC2; -.
DR   HGNC; HGNC:23468; DYDC2.
DR   HPA; ENSG00000133665; Tissue enriched (fallopian).
DR   neXtProt; NX_Q96IM9; -.
DR   OpenTargets; ENSG00000133665; -.
DR   PharmGKB; PA134988160; -.
DR   VEuPathDB; HostDB:ENSG00000133665; -.
DR   eggNOG; ENOG502S3U3; Eukaryota.
DR   GeneTree; ENSGT00940000162091; -.
DR   InParanoid; Q96IM9; -.
DR   OMA; RMETDYL; -.
DR   PhylomeDB; Q96IM9; -.
DR   TreeFam; TF330747; -.
DR   PathwayCommons; Q96IM9; -.
DR   SignaLink; Q96IM9; -.
DR   BioGRID-ORCS; 84332; 13 hits in 1059 CRISPR screens.
DR   ChiTaRS; DYDC2; human.
DR   GenomeRNAi; 84332; -.
DR   Pharos; Q96IM9; Tdark.
DR   PRO; PR:Q96IM9; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   RNAct; Q96IM9; protein.
DR   Bgee; ENSG00000133665; Expressed in right uterine tube and 111 other tissues.
DR   ExpressionAtlas; Q96IM9; baseline and differential.
DR   Genevisible; Q96IM9; HS.
DR   GO; GO:0044666; C:MLL3/4 complex; IEA:InterPro.
DR   GO; GO:0048188; C:Set1C/COMPASS complex; IBA:GO_Central.
DR   GO; GO:0051568; P:histone H3-K4 methylation; IBA:GO_Central.
DR   InterPro; IPR007858; Dpy-30_motif.
DR   InterPro; IPR037856; Sdc1/DPY30.
DR   PANTHER; PTHR23356; PTHR23356; 1.
DR   Pfam; PF05186; Dpy-30; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..177
FT                   /note="DPY30 domain-containing protein 2"
FT                   /id="PRO_0000247559"
FT   VARIANT         143
FT                   /note="G -> S (in dbSNP:rs1047951)"
FT                   /id="VAR_048889"
SQ   SEQUENCE   177 AA;  20586 MW;  52EB61B200612A74 CRC64;
     METNYLKRCF GNCLAQALAE VAKVRPSDPI EYLAHWLYHY RKTAKAKEEN REKKIHLQEE
     YDSSLKEMEM TEMLKQEEYQ IQQNCEKCHK ELTSETVSTK KTIFMQEDTN PLEKEALKQE
     FLPGTSSLIP GMPQQVPPSE SAGQIDQNFK MPQEINYKEA FQHEVAHEMP PGSKSPF