ADH_SULTO
ID ADH_SULTO Reviewed; 347 AA.
AC Q96XE0;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=NAD-dependent alcohol dehydrogenase;
DE EC=1.1.1.1;
GN Name=adh; OrderedLocusNames=STK_25770;
OS Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
OS (Sulfolobus tokodaii).
OC Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Sulfurisphaera.
OX NCBI_TaxID=273063;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16993 / JCM 10545 / NBRC 100140 / 7;
RX PubMed=11572479; DOI=10.1093/dnares/8.4.123;
RA Kawarabayasi Y., Hino Y., Horikawa H., Jin-no K., Takahashi M., Sekine M.,
RA Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y.,
RA Nishijima K., Otsuka R., Nakazawa H., Takamiya M., Kato Y., Yoshizawa T.,
RA Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K.,
RA Masuda S., Yanagii M., Nishimura M., Yamagishi A., Oshima T., Kikuchi H.;
RT "Complete genome sequence of an aerobic thermoacidophilic Crenarchaeon,
RT Sulfolobus tokodaii strain7.";
RL DNA Res. 8:123-140(2001).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH;
CC Xref=Rhea:RHEA:10736, ChEBI:CHEBI:15378, ChEBI:CHEBI:15734,
CC ChEBI:CHEBI:17478, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a secondary alcohol + NAD(+) = a ketone + H(+) + NADH;
CC Xref=Rhea:RHEA:10740, ChEBI:CHEBI:15378, ChEBI:CHEBI:17087,
CC ChEBI:CHEBI:35681, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.1;
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000250};
CC -!- SUBUNIT: Homodimer and homotetramer. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000305}.
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DR EMBL; BA000023; BAB67688.1; -; Genomic_DNA.
DR RefSeq; WP_010980662.1; NC_003106.2.
DR PDB; 2EER; X-ray; 2.10 A; A/B=1-347.
DR PDBsum; 2EER; -.
DR AlphaFoldDB; Q96XE0; -.
DR SMR; Q96XE0; -.
DR STRING; 273063.STK_25770; -.
DR EnsemblBacteria; BAB67688; BAB67688; STK_25770.
DR GeneID; 1460661; -.
DR KEGG; sto:STK_25770; -.
DR PATRIC; fig|273063.9.peg.2903; -.
DR eggNOG; arCOG01455; Archaea.
DR OMA; QYAHNVF; -.
DR OrthoDB; 31525at2157; -.
DR BRENDA; 1.1.1.1; 15396.
DR EvolutionaryTrace; Q96XE0; -.
DR Proteomes; UP000001015; Chromosome.
DR GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; SSF50129; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Metal-binding; Methylation; NAD; Oxidoreductase;
KW Reference proteome; Zinc.
FT CHAIN 1..347
FT /note="NAD-dependent alcohol dehydrogenase"
FT /id="PRO_0000160755"
FT BINDING 38
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT BINDING 68
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT BINDING 98
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 101
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 104
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 112
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 154
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT MOD_RES 11
FT /note="N6-methyllysine"
FT /evidence="ECO:0000250"
FT MOD_RES 213
FT /note="N6-methyllysine"
FT /evidence="ECO:0000250"
FT STRAND 2..6
FT /evidence="ECO:0007829|PDB:2EER"
FT STRAND 14..17
FT /evidence="ECO:0007829|PDB:2EER"
FT STRAND 28..37
FT /evidence="ECO:0007829|PDB:2EER"
FT HELIX 40..46
FT /evidence="ECO:0007829|PDB:2EER"
FT TURN 54..58
FT /evidence="ECO:0007829|PDB:2EER"
FT STRAND 62..65
FT /evidence="ECO:0007829|PDB:2EER"
FT STRAND 70..77
FT /evidence="ECO:0007829|PDB:2EER"
FT STRAND 89..92
FT /evidence="ECO:0007829|PDB:2EER"
FT STRAND 99..101
FT /evidence="ECO:0007829|PDB:2EER"
FT HELIX 102..105
FT /evidence="ECO:0007829|PDB:2EER"
FT HELIX 109..111
FT /evidence="ECO:0007829|PDB:2EER"
FT STRAND 116..118
FT /evidence="ECO:0007829|PDB:2EER"
FT TURN 119..121
FT /evidence="ECO:0007829|PDB:2EER"
FT STRAND 125..133
FT /evidence="ECO:0007829|PDB:2EER"
FT HELIX 135..137
FT /evidence="ECO:0007829|PDB:2EER"
FT STRAND 138..140
FT /evidence="ECO:0007829|PDB:2EER"
FT STRAND 142..144
FT /evidence="ECO:0007829|PDB:2EER"
FT HELIX 146..149
FT /evidence="ECO:0007829|PDB:2EER"
FT HELIX 150..153
FT /evidence="ECO:0007829|PDB:2EER"
FT HELIX 155..165
FT /evidence="ECO:0007829|PDB:2EER"
FT STRAND 173..177
FT /evidence="ECO:0007829|PDB:2EER"
FT TURN 178..180
FT /evidence="ECO:0007829|PDB:2EER"
FT HELIX 182..194
FT /evidence="ECO:0007829|PDB:2EER"
FT STRAND 198..205
FT /evidence="ECO:0007829|PDB:2EER"
FT HELIX 206..215
FT /evidence="ECO:0007829|PDB:2EER"
FT STRAND 218..222
FT /evidence="ECO:0007829|PDB:2EER"
FT TURN 223..225
FT /evidence="ECO:0007829|PDB:2EER"
FT HELIX 228..235
FT /evidence="ECO:0007829|PDB:2EER"
FT TURN 236..238
FT /evidence="ECO:0007829|PDB:2EER"
FT STRAND 241..247
FT /evidence="ECO:0007829|PDB:2EER"
FT HELIX 251..254
FT /evidence="ECO:0007829|PDB:2EER"
FT HELIX 257..260
FT /evidence="ECO:0007829|PDB:2EER"
FT STRAND 261..269
FT /evidence="ECO:0007829|PDB:2EER"
FT STRAND 276..280
FT /evidence="ECO:0007829|PDB:2EER"
FT HELIX 281..287
FT /evidence="ECO:0007829|PDB:2EER"
FT STRAND 290..293
FT /evidence="ECO:0007829|PDB:2EER"
FT HELIX 299..310
FT /evidence="ECO:0007829|PDB:2EER"
FT STRAND 318..323
FT /evidence="ECO:0007829|PDB:2EER"
FT HELIX 324..326
FT /evidence="ECO:0007829|PDB:2EER"
FT HELIX 327..335
FT /evidence="ECO:0007829|PDB:2EER"
FT STRAND 341..346
FT /evidence="ECO:0007829|PDB:2EER"
SQ SEQUENCE 347 AA; 37569 MW; 46059B8AE2382DF0 CRC64;
MRAMRLVEIG KPLKLEDIPI PKPKGSQVLI KIEAAGVCHS DVHMRQGRFG NLRIVEDLGV
KLPVTLGHEI AGRIEEVGDE VVGYSKGDLV AVNPWEGEGN CYYCRIGEEH LCDSPRWLGI
NYDGAYAEYV LVPHYKYLYK LRRLSAVEAA PLTCSGVTTY RAVRKASLDP SKTLVVIGAG
GGLGTMAIQI AKAVSGATII GVDVREEALE AAKRAGADYV INASSQDPVS EIRRITQGKG
ADAVIDLNNS EKTLSIYPYV LAKQGKYVMV GLFGADLKYH APLITLNEVQ FIGSLVGNQS
DFLGIMSLAE AGKVKPMVTK TMKLEEANEA IDNLENFKAV GRQVLVP