DYH1_MOUSE
ID DYH1_MOUSE Reviewed; 4250 AA.
AC E9Q8T7; O08828; Q8R584;
DT 22-NOV-2017, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Dynein axonemal heavy chain 1 {ECO:0000305};
DE AltName: Full=Axonemal beta dynein heavy chain 1;
DE AltName: Full=Ciliary dynein heavy chain 1;
DE AltName: Full=mDHC7 {ECO:0000303|PubMed:11371505};
GN Name=Dnah1 {ECO:0000312|MGI:MGI:107721};
GN Synonyms=Dhc7, Dnahc1 {ECO:0000312|MGI:MGI:107721};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=FVB/N;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 809-2156.
RC STRAIN=NMRI; TISSUE=Testis;
RX PubMed=9373155; DOI=10.1016/s0378-1119(97)00417-4;
RA Neesen J., Koehler M.R., Kirschner R., Steinlein C., Kreutzberger J.,
RA Engel W., Schmid M.;
RT "Identification of dynein heavy chain genes expressed in human and mouse
RT testis: chromosomal localization of an axonemal dynein gene.";
RL Gene 200:193-202(1997).
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RX PubMed=11371505; DOI=10.1093/hmg/10.11.1117;
RA Neesen J., Kirschner R., Ochs M., Schmiedl A., Habermann B., Mueller C.,
RA Holstein A.F., Nuesslein T., Adham I., Engel W.;
RT "Disruption of an inner arm dynein heavy chain gene results in
RT asthenozoospermia and reduced ciliary beat frequency.";
RL Hum. Mol. Genet. 10:1117-1128(2001).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic fibroblast;
RX PubMed=19131326; DOI=10.1074/mcp.m800451-mcp200;
RA Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
RT "Large scale localization of protein phosphorylation by use of electron
RT capture dissociation mass spectrometry.";
RL Mol. Cell. Proteomics 8:904-912(2009).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Force generating protein of cilia required for sperm
CC flagellum motility (PubMed:11371505). Produces force towards the minus
CC ends of microtubules. Dynein has ATPase activity; the force-producing
CC power stroke is thought to occur on release of ADP (By similarity).
CC Required in spermatozoa for the formation of the inner dynein arms and
CC biogenesis of the axoneme (By similarity).
CC {ECO:0000250|UniProtKB:Q9P2D7, ECO:0000269|PubMed:11371505}.
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000250|UniProtKB:Q8TE73}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:Q9P2D7}. Cell projection, cilium, flagellum
CC {ECO:0000269|PubMed:11371505}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=E9Q8T7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=E9Q8T7-2; Sequence=VSP_059235, VSP_059236;
CC -!- DISRUPTION PHENOTYPE: Mice are viable and show no malformations;
CC however, homozygous males are infertile, due to inability of
CC spermatozoa to move from the uterus into the oviduct. Spermatozoa show
CC decreased motility. In addition, tracheal beating frequency is reduced.
CC {ECO:0000269|PubMed:11371505}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK053204; BAC35309.1; -; mRNA.
DR EMBL; AC108416; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466573; EDL24805.1; -; Genomic_DNA.
DR EMBL; BC023155; AAH23155.1; -; mRNA.
DR EMBL; Z83815; CAB06069.2; -; mRNA.
DR CCDS; CCDS49436.1; -. [E9Q8T7-1]
DR RefSeq; NP_001028840.1; NM_001033668.1. [E9Q8T7-1]
DR RefSeq; XP_017171287.1; XM_017315798.1.
DR RefSeq; XP_017171288.1; XM_017315799.1. [E9Q8T7-1]
DR SMR; E9Q8T7; -.
DR STRING; 10090.ENSMUSP00000043281; -.
DR iPTMnet; E9Q8T7; -.
DR PhosphoSitePlus; E9Q8T7; -.
DR jPOST; E9Q8T7; -.
DR MaxQB; E9Q8T7; -.
DR PaxDb; E9Q8T7; -.
DR PRIDE; E9Q8T7; -.
DR ProteomicsDB; 277420; -. [E9Q8T7-1]
DR ProteomicsDB; 277421; -. [E9Q8T7-2]
DR Antibodypedia; 48327; 53 antibodies from 13 providers.
DR DNASU; 110084; -.
DR Ensembl; ENSMUST00000048603; ENSMUSP00000043281; ENSMUSG00000019027. [E9Q8T7-1]
DR GeneID; 110084; -.
DR KEGG; mmu:110084; -.
DR UCSC; uc007sxk.2; mouse. [E9Q8T7-1]
DR UCSC; uc007sxl.1; mouse.
DR CTD; 25981; -.
DR MGI; MGI:107721; Dnah1.
DR VEuPathDB; HostDB:ENSMUSG00000019027; -.
DR eggNOG; KOG3595; Eukaryota.
DR GeneTree; ENSGT00940000154791; -.
DR HOGENOM; CLU_000038_0_0_1; -.
DR InParanoid; E9Q8T7; -.
DR OMA; YWESAQK; -.
DR OrthoDB; 3185at2759; -.
DR PhylomeDB; E9Q8T7; -.
DR TreeFam; TF316836; -.
DR BioGRID-ORCS; 110084; 3 hits in 71 CRISPR screens.
DR PRO; PR:E9Q8T7; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; E9Q8T7; protein.
DR Bgee; ENSMUSG00000019027; Expressed in spermatocyte and 112 other tissues.
DR Genevisible; E9Q8T7; MM.
DR GO; GO:0005930; C:axoneme; ISO:MGI.
DR GO; GO:0030286; C:dynein complex; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0036156; C:inner dynein arm; ISO:MGI.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0036126; C:sperm flagellum; IDA:MGI.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IBA:GO_Central.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IBA:GO_Central.
DR GO; GO:0003777; F:microtubule motor activity; IC:MGI.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IBA:GO_Central.
DR GO; GO:0003341; P:cilium movement; IBA:GO_Central.
DR GO; GO:0060294; P:cilium movement involved in cell motility; IMP:MGI.
DR GO; GO:0003351; P:epithelial cilium movement involved in extracellular fluid movement; IMP:MGI.
DR GO; GO:0030317; P:flagellated sperm motility; IMP:MGI.
DR GO; GO:0036159; P:inner dynein arm assembly; ISO:MGI.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR GO; GO:0007288; P:sperm axoneme assembly; ISO:MGI.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.10.8.720; -; 1.
DR Gene3D; 1.20.140.100; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 3.20.180.20; -; 1.
DR Gene3D; 3.40.50.300; -; 5.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; SSF52540; 4.
PE 1: Evidence at protein level;
KW Alternative splicing; ATP-binding; Cell projection; Cilium; Coiled coil;
KW Cytoplasm; Cytoskeleton; Dynein; Flagellum; Microtubule; Motor protein;
KW Nucleotide-binding; Reference proteome.
FT CHAIN 1..4250
FT /note="Dynein axonemal heavy chain 1"
FT /id="PRO_0000442430"
FT REGION 1..1527
FT /note="Stem"
FT /evidence="ECO:0000250"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1528..1749
FT /note="AAA 1"
FT /evidence="ECO:0000250"
FT REGION 1809..2042
FT /note="AAA 2"
FT /evidence="ECO:0000250"
FT REGION 2174..2434
FT /note="AAA 3"
FT /evidence="ECO:0000250"
FT REGION 2532..2784
FT /note="AAA 4"
FT /evidence="ECO:0000250"
FT REGION 2799..3097
FT /note="Stalk"
FT /evidence="ECO:0000250"
FT REGION 3182..3412
FT /note="AAA 5"
FT /evidence="ECO:0000250"
FT REGION 3625..3844
FT /note="AAA 6"
FT /evidence="ECO:0000250"
FT COILED 3045..3128
FT /evidence="ECO:0000255"
FT MOTIF 1566..1573
FT /note="GPAGTGKT motif"
FT MOTIF 1616..1622
FT /note="CFDEFNR motif"
FT BINDING 1566..1573
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT BINDING 1847..1854
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT BINDING 2212..2219
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT BINDING 2571..2578
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT VAR_SEQ 468..486
FT /note="LVSVPEYPFREQKEDFTFV -> ESHWTLAAHLASSPHLRLS (in
FT isoform 2)"
FT /id="VSP_059235"
FT VAR_SEQ 487..4250
FT /note="Missing (in isoform 2)"
FT /id="VSP_059236"
FT CONFLICT 839
FT /note="I -> L (in Ref. 5; CAB06069)"
FT /evidence="ECO:0000305"
FT CONFLICT 854
FT /note="D -> V (in Ref. 5; CAB06069)"
FT /evidence="ECO:0000305"
FT CONFLICT 1111
FT /note="A -> G (in Ref. 5; CAB06069)"
FT /evidence="ECO:0000305"
FT CONFLICT 1136
FT /note="V -> M (in Ref. 5; CAB06069)"
FT /evidence="ECO:0000305"
FT CONFLICT 1302
FT /note="Y -> S (in Ref. 5; CAB06069)"
FT /evidence="ECO:0000305"
FT CONFLICT 1389
FT /note="S -> I (in Ref. 5; CAB06069)"
FT /evidence="ECO:0000305"
FT CONFLICT 1406
FT /note="P -> L (in Ref. 5; CAB06069)"
FT /evidence="ECO:0000305"
FT CONFLICT 1427
FT /note="Q -> R (in Ref. 5; CAB06069)"
FT /evidence="ECO:0000305"
FT CONFLICT 2025..2046
FT /note="LFTKYLENSINFVRNTVKEVIA -> SLPSTWRIPSTCSEHSEGSDC (in
FT Ref. 5; CAB06069)"
FT /evidence="ECO:0000305"
FT CONFLICT 2052
FT /note="L -> V (in Ref. 5; CAB06069)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 4250 AA; 487070 MW; 27CA12B77EC9E3F9 CRC64;
MEECNKEGPS SSSQGPGYCP VKVPESHDLE KILQESNYHP ERNPLNPDPK TPPLPLTDLR
QPRKSPLTGT DKKYPLMKQR GFYSDILSPG TLDKLGNVCC GPYMSQNLIR QADLDKFTPK
VDSFVIPEDF QERVEQQIIG ATTRLLTQTD FPLQSYEPKV QVPFQVLPGQ CPRKIEIERR
KQQYLRLDIE QLLTSEGIDS NKLMPRHPDL QHPQTIEQGR DPLFPIYLPL KVFDNEEFDC
RTPTEWLNMG LEPGSQNRKP VPGKALLPTD DDLGHEDPKN QELDYRWCEV GVLDYDEEKK
LYLVQKTDKR GLVRDEMGMP ILNGGITPAG RPPLLATQYW VPRIQLLFCA EDPRVFTQRV
VQANALRKYT EALLMYNLYV DCMPTEGRRV INEQSLSKIK QWALSTPRMR KGQSVLEHLS
CLAREVNLDY ERSMNKINFD QIVSSNPETF SYVTLPEKEE EKVPNQGLVS VPEYPFREQK
EDFTFVSLLT RPEVITALSK VRAECNKVTS MSLFHSSLSK YSRLEEFEQI QSQTFSQVQM
FLKDSWISTL KVAMRGSLRD MSKGWYNLYE TNWEVYLMSK LRKLMELIKY MLQDTLRFLV
QDSLGSFTQF IGDACCSVLE CVDDMDWGED LVNSPYKPRK NPLFIVDLVL DNSGVHYSTP
LEHFEMILLN LFDKGILATH AVPQLEKLVM EDIFISGDPL LESVGLHEPL VEELRANITN
AMHKAMMPLQ AYAKEYRKYL ELNNNDISTF LKTYQTQCPS AEEVREVVIT HLKEKEILDN
SLPSSIIIGP FYINVDNVKQ SLSKKRKALA TSMLDILAKN LHKEVDSICE EFRSISRKIY
EKPNSIEELA ELRDWMKGIP EKLVFLEERI VKVMSDYEVM DEFFYNLTTD DFNDKWAANN
WPSKILGQID MVRQQHVEDE EKFRKIQLMD QNNFQEKLEG LQLVVAGFSI HVEIARAHEI
ANEVRRVKKQ LKDCQQLAML YNNRERIFGL PITNYDKLSR MVKEFQPYLD LWTTASDWLR
WSESWMNDPL SAIDAEQLEK NVIESFKTMH KCVKQFKDIP ACQEVALDIR TRIEEFKPYI
PLIQGLRNPG MRNRHWEVLS NEININVRPK ANLTFARCLE MNLQDHIESI SKVAEVAGKE
YAIEQALDKM EKEWSSILFN VLPYKETDTY ILKSPDEASQ LLDDHIVMTQ SMSFSPYKKP
FEQRINSWET KLKLTQEVLE EWLNCQRAWL YLEPIFSSED ITRQLPVESK RYQTMERIWR
KIMKNAYENR EVINVCSDQR LLDSLRDCNK LLDLVQKGLS EYLETKRTAF PRFYFLSDDE
LLEILSQTKD PTAVQPHLRK CFENIARLLF QEDLEITHMY SAEGEEVKLS FSIYPSSNVE
DWLLEVERSM KASVHDIIEM AIKAYPTMLR TEWVLNWPGQ VTIAGCQTYW TMEVAEALEA
GNISSKLFPQ LSKQLSDLVA LVRGKLSRMQ RMVLSALIVI EVHAKDVVSK LIDENVVSVH
DFEWISQLRY YWTKDDLYIR AVNAEFIYGY EYLGNSGRLV ITPLTDRCYL TLTGALHLKF
GGAPAGPAGT GKTETTKDLG KALAIQTVVF NCSDQLDFMA MGKFFKGLAS AGAWACFDEF
NRIDIEVLSV VAQQITTIQK AQQQRVERFM FEGVEIPLVP SCAVFITMNP GYAGRTELPD
NLKALFRPVA MMVPDYAMIA EISLYSFGFN EANVLAKKIT TTFKLSSEQL SSQDHYDFGM
RAVKTVISAA GNLKRENPTM NEELICLRAI RDVNVPKFLQ EDLKLFSGIV SDLFPTIKEE
ETDYGILDQA IRRSCEKNNL KDVEGFLIKC IQLYETTVVR HGLMLVGPTG SGKSNCYRVL
AAAMTLLKGK PSISGGVYEA VNYYVLNPKS ITMGQLYGEF DLLTHEWTDG IFSSLIRAGA
IASDTNKKWY MFDGPVDAVW IENMNTVLDD NKKLCLSSGE IIKLTEAMTM MFEVQDLAVA
SPATVSRCGM VYLEPSILGL MPFVECWLKR LPAIIKPYEE QFKSLFTKYL ENSINFVRNT
VKEVIASTNS NLTMSLLKLL DCFFRPFLPR EGLKKIPSEK LSHIPELIEP WFIFSLVWSV
GATGDHTSRI SFSQWLRLKM RLEQVKLGFP EDGLVYDYRL DDAGISSTED DDEEEDENKQ
VSWVKWMDYS APFTMMPDTN YCNIIVPTMD TVQMSYLLGM LLTNHKPVLC IGPTGTGKTL
TVSNKLLKYL PLEYISHFLT FSARTSANQT QDLIDSKLDK RRKGVFGPPL GRNFIFFIDD
LNMPALETYG AQPPIELLRQ WMDHGGWYDR KVIGAFKNLV DINFVCAMGP PGGGRNAITP
RLTRHFNYLS FIEMDEVSKK RIFSIILECW MDGLLGEKSY REPVPGAPNI DDLTEPLVDA
TINVYGIITS QLLPTPAKSH YTFNLRDLSK VFQGMLMAEP SKVEDKVQLL RLWYHENCRV
FRDRLVNEED RSWFDELLEA QMEEFGVAFN KVCPFQPILY GDFMSPGSDV KSYELITSES
KMMQVIEEYM EDYNQINTAK LRLVLFVDAM SHICRISRTL RQALGNALLL GVGGSGRSSL
TRLASHMAEY ECFQIELSKN YGMSEWREDV KKVLLKAGLQ NLPITFLFSD TQIKNESFLE
DINNVLNSGD IPNIYSADEQ DQIINTMRPY IQEQGLQPTK ANLMAAYTGR VRSNIHMVLC
MSPIGEVFRA RLRQFPSLVN CCTIDWFNEW PAEALKSVAT TFLSEIPELE CSEEVIQGLI
QVCVFIHQSV ASKCVEYLAE LARHNYVTPK SYLELLNIFS ILIGQKKMEL KTAKNRMKSG
LDKLLRTSED VAKMQEELEI MRPLLEEAAK DTMLTMEQIK VDTAIAEETR KSVQAEEIKA
NEKANKAQAI ADDAQKDLDE ALPALDAALA SLRNLNKNDV TEVRAMQRPP PGVKLVIEAV
CIMKGIKPKK VPGEKPGSKV DDYWEPGKGL LQDPGRFLES LFKFDKDNIG EAVIKAIQPY
IDNEEFQPAA IAKVSKACTS ICQWVRAMHK YHFVAKAVEP KRQALREAQD DLEVTQRILE
EAKHHLHEVE DGIATMQAKY RECVAKKEEL EMKCEQCEQR LGRADKLING LADEKVRWQE
TVENLENMLD NIFGDVLVAA GFVAYLGPFT GQYRTTLYEY WVNQLTVHHV PHTSKPTLIT
TLGNPVKIRS WQIAGLPNDT LSVENGVINQ FSQRWTHFID PQGQANKWIK NMERESGLDV
FKLSDRDFLR SMENAIRFGK PCLLENVGEE LDPALEPVLL KQTYKQQGNI VLKLGDTVIP
YHEDFRMYIT TKLPNPHYSP EISTKLTLIN FTLSPSGLED QLLGQVVAEE RPDLEEAKNQ
LIVSNAKMRQ ELKDIEDQIL YRLSSSEGNP VDDMELIKVL EASKMKAAEI QAKVRIAEQT
EKDIDLTRME YIPVAVRTQI LFFCVSDLAN VDPMYQYSLE WFLNIFLSGI ANSERADNLK
KRIVNINRYL TFSLYSNVCR SLFEKHKLMF AFLLCVRIMM NEGKINQAEW RYLLSGGSIQ
TMFENPAPQW LSDRAWRDIL ALSNLPTFAT FSNDFVMYLS EFQAIFDSAE PHRELLPGIW
NAYLDEFQKL LILRCLRGDK VTNAMQDFVA THLEPRFIEP QTANLSAVFK ESNSTTPLIF
VLSPGTDPAA DLYKFAEEMK FSKKFSAISL GQGQGPRAEA MMRNSIERGK WVFFQNCHLA
PSWMPALERL IEHINPDKVH RDFRLWLTSL PSNKFPVSIL QNGSKMTIEP PRGVKANLLK
SYNSLSDDFL HSCQKVVEFK SLLLSLCLFH GNALERRKFG PLGFNIPYEF TDGDLRICIS
QLKMFLDEYE DIPYKVLKYT AGEINYGGRV TDDWDRRCVM NILEDFYNPA VLSSEHSYSN
SGIYHQIPPT YDLNGYLSYI KSLPLNDMPE IFGLHDNANI TFAQNETFAL FNAILQLQPK
SSSMGGQSRE ELVEDVAENI LLQVPGPIEL QEVTKKFPVL YEESMNTVLV QEVIRYNKLL
EVITQTLSDM LKAIKGLVVM SLELELMSIS LYNNTVPELW KSKAYPSLKP LASWIMDLLL
RLDFMHSWIN DGIPPVFWIS GFFFPQAFLT GTLQNFARKF VISIDTITFD FKVLPEASSE
IKERPQTGCY IHGLFLEGAR WDSMNFQLAE SRPKELYTEM AVIWLLPEAN RKVQNQDFYL
CPIYKTLTRA GTLSTTGHST NYVIAVEIPS NQPQRHWIKR GVALICALDY
