DYHC2_HUMAN
ID DYHC2_HUMAN Reviewed; 4307 AA.
AC Q8NCM8; O00432; Q16693; Q3C1U8; Q4AC93; Q6ZMX7; Q6ZUM6; Q7Z363; Q8N977;
AC Q92815; Q9HAE4;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 4.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Cytoplasmic dynein 2 heavy chain 1;
DE AltName: Full=Cytoplasmic dynein 2 heavy chain;
DE AltName: Full=Dynein cytoplasmic heavy chain 2;
DE AltName: Full=Dynein heavy chain 11;
DE Short=hDHC11;
DE AltName: Full=Dynein heavy chain isotype 1B;
GN Name=DYNC2H1; Synonyms=DHC1B, DHC2, DNCH2, DYH1B, KIAA1997;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1911-2004 (ISOFORM 1).
RA Totoki Y., Yada T., Sakaki Y., Takeda T.;
RT "Identification of novel human genes predicted by combining multiple gene
RT finders.";
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1088 AND 2955-4307 (ISOFORM 1).
RC TISSUE=Brain, Embryo, Placenta, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1091-1745 (ISOFORM 1), VARIANT ARG-1413,
RP TOPOLOGY, AND SUBCELLULAR LOCATION.
RX PubMed=8666668; DOI=10.1083/jcb.133.4.831;
RA Vaisberg E.A., Grissom P.M., McIntosh J.R.;
RT "Mammalian cells express three distinct dynein heavy chains that are
RT localized to different cytoplasmic organelles.";
RL J. Cell Biol. 133:831-842(1996).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1671-1831 (ISOFORM 1).
RC TISSUE=Liver;
RX PubMed=8186465; DOI=10.1091/mbc.5.1.57;
RA Gibbons B.H., Asai D.J., Tang W.-J.Y., Hays T.S., Gibbons I.R.;
RT "Phylogeny and expression of axonemal and cytoplasmic dynein genes in sea
RT urchins.";
RL Mol. Biol. Cell 5:57-70(1994).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1689-1867 (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=9373155; DOI=10.1016/s0378-1119(97)00417-4;
RA Neesen J., Koehler M.R., Kirschner R., Steinlein C., Kreutzberger J.,
RA Engel W., Schmid M.;
RT "Identification of dynein heavy chain genes expressed in human and mouse
RT testis: chromosomal localization of an axonemal dynein gene.";
RL Gene 200:193-202(1997).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2583-4307 (ISOFORM 2), AND
RP VARIANT GLN-2871.
RC TISSUE=Retina;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2623-4307 (ISOFORM 1), AND
RP VARIANTS GLN-2871 AND VAL-3680.
RC TISSUE=Brain;
RX PubMed=12056414; DOI=10.1093/dnares/9.2.47;
RA Ohara O., Nagase T., Mitsui G., Kohga H., Kikuno R., Hiraoka S.,
RA Takahashi Y., Kitajima S., Saga Y., Koseki H.;
RT "Characterization of size-fractionated cDNA libraries generated by the in
RT vitro recombination-assisted method.";
RL DNA Res. 9:47-57(2002).
RN [9]
RP SEQUENCE REVISION.
RA Ohara O., Nagase T., Yamakawa H., Kikuno R.;
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN [10]
RP NOMENCLATURE.
RX PubMed=16440056; DOI=10.1371/journal.pgen.0020001;
RA Pfister K.K., Shah P.R., Hummerich H., Russ A., Cotton J., Annuar A.A.,
RA King S.M., Fisher E.M.C.;
RT "Genetic analysis of the cytoplasmic dynein subunit families.";
RL PLoS Genet. 2:11-26(2006).
RN [11]
RP INVOLVEMENT IN DIGENIC SHORT-RIB THORACIC DYSPLASIA 3/6 WITH POLYDACTYLY,
RP AND VARIANT ASP-3909.
RX PubMed=21211617; DOI=10.1016/j.ajhg.2010.12.004;
RA Thiel C., Kessler K., Giessl A., Dimmler A., Shalev S.A., von der Haar S.,
RA Zenker M., Zahnleiter D., Stoess H., Beinder E., Abou Jamra R., Ekici A.B.,
RA Schroeder-Kress N., Aigner T., Kirchner T., Reis A., Brandstaetter J.H.,
RA Rauch A.;
RT "NEK1 mutations cause short-rib polydactyly syndrome type majewski.";
RL Am. J. Hum. Genet. 88:106-114(2011).
RN [12]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [13]
RP VARIANTS SRTD3 ILE-209; CYS-587 AND HIS-2205.
RX PubMed=19361615; DOI=10.1016/j.ajhg.2009.03.015;
RA Merrill A.E., Merriman B., Farrington-Rock C., Camacho N., Sebald E.T.,
RA Funari V.A., Schibler M.J., Firestein M.H., Cohn Z.A., Priore M.A.,
RA Thompson A.K., Rimoin D.L., Nelson S.F., Cohn D.H., Krakow D.;
RT "Ciliary abnormalities due to defects in the retrograde transport protein
RT DYNC2H1 in short-rib polydactyly syndrome.";
RL Am. J. Hum. Genet. 84:542-549(2009).
RN [14]
RP VARIANTS SRTD3 THR-1240; ALA-1987; LEU-1991; VAL-2461; GLY-3015 AND
RP VAL-3762.
RX PubMed=19442771; DOI=10.1016/j.ajhg.2009.04.016;
RA Dagoneau N., Goulet M., Genevieve D., Sznajer Y., Martinovic J.,
RA Smithson S., Huber C., Baujat G., Flori E., Tecco L., Cavalcanti D.,
RA Delezoide A.-L., Serre V., Le Merrer M., Munnich A., Cormier-Daire V.;
RT "DYNC2H1 mutations cause asphyxiating thoracic dystrophy and short rib-
RT polydactyly syndrome, type III.";
RL Am. J. Hum. Genet. 84:706-711(2009).
RN [15]
RP VARIANTS SRTD3 CYS-330; GLY-338; CYS-430; ARG-495; CYS-1423; SER-2496 AND
RP GLN-2662.
RX PubMed=22499340; DOI=10.1136/jmedgenet-2011-100717;
RA El Hokayem J., Huber C., Couve A., Aziza J., Baujat G., Bouvier R.,
RA Cavalcanti D.P., Collins F.A., Cordier M.P., Delezoide A.L., Gonzales M.,
RA Johnson D., Le Merrer M., Levy-Mozziconacci A., Loget P.,
RA Martin-Coignard D., Martinovic J., Mortier G.R., Perez M.J., Roume J.,
RA Scarano G., Munnich A., Cormier-Daire V.;
RT "NEK1 and DYNC2H1 are both involved in short rib polydactyly Majewski type
RT but not in Beemer Langer cases.";
RL J. Med. Genet. 49:227-233(2012).
RN [16]
RP VARIANTS SRTD3 CYS-330; PRO-871; ILE-1228; THR-1240; VAL-1379; ASP-1442;
RP LYS-1991; VAL-2227; THR-2304; SER-2362; GLN-2481; TRP-2532; MET-2555;
RP CYS-2573; THR-2640; MET-2819; GLY-3015; LEU-3381; CYS-3806; GLY-3847 AND
RP ARG-4232.
RX PubMed=23456818; DOI=10.1136/jmedgenet-2012-101284;
RA Schmidts M., Arts H.H., Bongers E.M., Yap Z., Oud M.M., Antony D.,
RA Duijkers L., Emes R.D., Stalker J., Yntema J.B., Plagnol V., Hoischen A.,
RA Gilissen C., Forsythe E., Lausch E., Veltman J.A., Roeleveld N.,
RA Superti-Furga A., Kutkowska-Kazmierczak A., Kamsteeg E.J., Elcioglu N.,
RA van Maarle M.C., Graul-Neumann L.M., Devriendt K., Smithson S.F.,
RA Wellesley D., Verbeek N.E., Hennekam R.C., Kayserili H., Scambler P.J.,
RA Beales P.L., Knoers N.V., Roepman R., Mitchison H.M.;
RT "Exome sequencing identifies DYNC2H1 mutations as a common cause of
RT asphyxiating thoracic dystrophy (Jeune syndrome) without major polydactyly,
RT renal or retinal involvement.";
RL J. Med. Genet. 50:309-323(2013).
CC -!- FUNCTION: May function as a motor for intraflagellar retrograde
CC transport. Functions in cilia biogenesis. May play a role in transport
CC between endoplasmic reticulum and Golgi or organization of the Golgi in
CC cells (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: The cytoplasmic dynein complex 2 is probably composed by a
CC heavy chain DYNC2H1 homodimer and a number of DYNC2LI1 light
CC intermediate chains. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:Q9JJ79}. Cell membrane
CC {ECO:0000250|UniProtKB:Q45VK7}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q45VK7}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q9JJ79}. Note=Localizes to the apical cytoplasm
CC (By similarity). According to PubMed:8666668, it localizes to Golgi
CC apparatus, cytoplasmic vesicle and endoplasmic reticulum
CC (PubMed:8666668). {ECO:0000250|UniProtKB:Q9JJ79,
CC ECO:0000269|PubMed:8666668}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8NCM8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NCM8-2; Sequence=VSP_031283;
CC Name=3;
CC IsoId=Q8NCM8-3; Sequence=VSP_031282;
CC -!- DISEASE: Short-rib thoracic dysplasia 3 with or without polydactyly
CC (SRTD3) [MIM:613091]: A form of short-rib thoracic dysplasia, a group
CC of autosomal recessive ciliopathies that are characterized by a
CC constricted thoracic cage, short ribs, shortened tubular bones, and a
CC 'trident' appearance of the acetabular roof. Polydactyly is variably
CC present. Non-skeletal involvement can include cleft lip/palate as well
CC as anomalies of major organs such as the brain, eye, heart, kidneys,
CC liver, pancreas, intestines, and genitalia. Some forms of the disease
CC are lethal in the neonatal period due to respiratory insufficiency
CC secondary to a severely restricted thoracic cage, whereas others are
CC compatible with life. Disease spectrum encompasses Ellis-van Creveld
CC syndrome, asphyxiating thoracic dystrophy (Jeune syndrome), Mainzer-
CC Saldino syndrome, and short rib-polydactyly syndrome.
CC {ECO:0000269|PubMed:19361615, ECO:0000269|PubMed:19442771,
CC ECO:0000269|PubMed:22499340, ECO:0000269|PubMed:23456818}. Note=The
CC disease is caused by variants affecting the gene represented in this
CC entry. In some cases DYNC2H1 mutations result in disease phenotype in
CC the presence of mutations in NEK1 indicating digenic inheritance
CC (digenic short rib-polydactyly syndrome 3/6 with polydactyly)
CC (PubMed:21211617). {ECO:0000269|PubMed:21211617}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB13905.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC04578.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAD18598.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB231765; BAE46899.1; -; mRNA.
DR EMBL; AB231766; BAE17138.1; -; mRNA.
DR EMBL; AP000817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP001486; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP002829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP002961; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP003382; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP003461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK021818; BAB13905.1; ALT_INIT; mRNA.
DR EMBL; AK095579; BAC04578.1; ALT_INIT; mRNA.
DR EMBL; AK125524; BAC86194.1; -; mRNA.
DR EMBL; AK131453; BAD18598.1; ALT_INIT; mRNA.
DR EMBL; U53531; AAB09728.1; -; mRNA.
DR EMBL; U20552; AAB50020.1; -; mRNA.
DR EMBL; Z83800; CAB06054.1; -; mRNA.
DR EMBL; BX538093; CAD98012.1; -; mRNA.
DR EMBL; AB082528; BAC02706.2; -; mRNA.
DR CCDS; CCDS44717.1; -. [Q8NCM8-2]
DR CCDS; CCDS53701.1; -. [Q8NCM8-1]
DR RefSeq; NP_001073932.1; NM_001080463.1. [Q8NCM8-2]
DR RefSeq; NP_001368.2; NM_001377.2. [Q8NCM8-1]
DR PDB; 4RH7; X-ray; 3.41 A; A=1091-4307.
DR PDBsum; 4RH7; -.
DR SMR; Q8NCM8; -.
DR BioGRID; 122785; 64.
DR CORUM; Q8NCM8; -.
DR IntAct; Q8NCM8; 30.
DR MINT; Q8NCM8; -.
DR STRING; 9606.ENSP00000381167; -.
DR iPTMnet; Q8NCM8; -.
DR PhosphoSitePlus; Q8NCM8; -.
DR BioMuta; DYNC2H1; -.
DR DMDM; 311033479; -.
DR EPD; Q8NCM8; -.
DR jPOST; Q8NCM8; -.
DR MassIVE; Q8NCM8; -.
DR MaxQB; Q8NCM8; -.
DR PaxDb; Q8NCM8; -.
DR PeptideAtlas; Q8NCM8; -.
DR PRIDE; Q8NCM8; -.
DR ProteomicsDB; 72909; -. [Q8NCM8-1]
DR ProteomicsDB; 72910; -. [Q8NCM8-2]
DR ProteomicsDB; 72911; -. [Q8NCM8-3]
DR Antibodypedia; 51715; 56 antibodies from 13 providers.
DR DNASU; 79659; -.
DR Ensembl; ENST00000334267.11; ENSP00000334021.7; ENSG00000187240.17. [Q8NCM8-3]
DR Ensembl; ENST00000375735.7; ENSP00000364887.2; ENSG00000187240.17. [Q8NCM8-1]
DR Ensembl; ENST00000650373.2; ENSP00000497174.1; ENSG00000187240.17. [Q8NCM8-2]
DR GeneID; 79659; -.
DR KEGG; hsa:79659; -.
DR MANE-Select; ENST00000375735.7; ENSP00000364887.2; NM_001377.3; NP_001368.2.
DR UCSC; uc001phn.2; human. [Q8NCM8-1]
DR CTD; 79659; -.
DR DisGeNET; 79659; -.
DR GeneCards; DYNC2H1; -.
DR HGNC; HGNC:2962; DYNC2H1.
DR HPA; ENSG00000187240; Low tissue specificity.
DR MalaCards; DYNC2H1; -.
DR MIM; 603297; gene.
DR MIM; 613091; phenotype.
DR neXtProt; NX_Q8NCM8; -.
DR OpenTargets; ENSG00000187240; -.
DR Orphanet; 474; Jeune syndrome.
DR Orphanet; 93269; Short rib-polydactyly syndrome, Majewski type.
DR Orphanet; 93270; Short rib-polydactyly syndrome, Saldino-Noonan type.
DR Orphanet; 93271; Short rib-polydactyly syndrome, Verma-Naumoff type.
DR VEuPathDB; HostDB:ENSG00000187240; -.
DR eggNOG; KOG3595; Eukaryota.
DR GeneTree; ENSGT00940000154620; -.
DR HOGENOM; CLU_000038_7_2_1; -.
DR InParanoid; Q8NCM8; -.
DR OMA; PFMLIGP; -.
DR OrthoDB; 26380at2759; -.
DR PhylomeDB; Q8NCM8; -.
DR TreeFam; TF315251; -.
DR PathwayCommons; Q8NCM8; -.
DR Reactome; R-HSA-5610787; Hedgehog 'off' state.
DR Reactome; R-HSA-5620924; Intraflagellar transport.
DR SignaLink; Q8NCM8; -.
DR BioGRID-ORCS; 79659; 16 hits in 1077 CRISPR screens.
DR ChiTaRS; DYNC2H1; human.
DR GeneWiki; DYNC2H1; -.
DR GenomeRNAi; 79659; -.
DR Pharos; Q8NCM8; Tbio.
DR PRO; PR:Q8NCM8; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NCM8; protein.
DR Bgee; ENSG00000187240; Expressed in secondary oocyte and 146 other tissues.
DR ExpressionAtlas; Q8NCM8; baseline and differential.
DR Genevisible; Q8NCM8; HS.
DR GO; GO:0045177; C:apical part of cell; IEA:Ensembl.
DR GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR GO; GO:0097542; C:ciliary tip; TAS:Reactome.
DR GO; GO:0005929; C:cilium; TAS:Reactome.
DR GO; GO:0005868; C:cytoplasmic dynein complex; IDA:GO_Central.
DR GO; GO:0030286; C:dynein complex; IBA:GO_Central.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
DR GO; GO:0005874; C:microtubule; IDA:UniProtKB.
DR GO; GO:0031514; C:motile cilium; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003774; F:cytoskeletal motor activity; NAS:UniProtKB.
DR GO; GO:0045505; F:dynein intermediate chain binding; IBA:GO_Central.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IBA:GO_Central.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR GO; GO:0060976; P:coronary vasculature development; IEA:Ensembl.
DR GO; GO:0007368; P:determination of left/right symmetry; IEA:Ensembl.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IEA:Ensembl.
DR GO; GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
DR GO; GO:0030900; P:forebrain development; IEA:Ensembl.
DR GO; GO:0007030; P:Golgi organization; IDA:UniProtKB.
DR GO; GO:0035721; P:intraciliary retrograde transport; IBA:GO_Central.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR GO; GO:1905515; P:non-motile cilium assembly; IEA:Ensembl.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IEA:Ensembl.
DR GO; GO:0061512; P:protein localization to cilium; IEA:Ensembl.
DR GO; GO:0016485; P:protein processing; IEA:Ensembl.
DR GO; GO:0021522; P:spinal cord motor neuron differentiation; IEA:Ensembl.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.10.8.720; -; 1.
DR Gene3D; 1.20.140.100; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 3.20.180.20; -; 1.
DR Gene3D; 3.40.50.300; -; 5.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR026815; DYNC2H1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676; PTHR10676; 1.
DR PANTHER; PTHR10676:SF352; PTHR10676:SF352; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; SSF52540; 4.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; ATP-binding; Cell membrane;
KW Cell projection; Ciliopathy; Cilium; Cilium biogenesis/degradation;
KW Coiled coil; Cytoplasm; Cytoskeleton; Developmental protein;
KW Disease variant; Dynein; Membrane; Microtubule; Motor protein;
KW Nucleotide-binding; Reference proteome.
FT CHAIN 1..4307
FT /note="Cytoplasmic dynein 2 heavy chain 1"
FT /id="PRO_0000318743"
FT REGION 1..1650
FT /note="Stem"
FT /evidence="ECO:0000250"
FT REGION 1651..1875
FT /note="AAA 1"
FT /evidence="ECO:0000250"
FT REGION 1938..2161
FT /note="AAA 2"
FT /evidence="ECO:0000250"
FT REGION 2251..2505
FT /note="AAA 3"
FT /evidence="ECO:0000250"
FT REGION 2617..2863
FT /note="AAA 4"
FT /evidence="ECO:0000250"
FT REGION 2881..3169
FT /note="Stalk"
FT /evidence="ECO:0000250"
FT REGION 3244..3473
FT /note="AAA 5"
FT /evidence="ECO:0000250"
FT REGION 3690..3905
FT /note="AAA 6"
FT /evidence="ECO:0000250"
FT COILED 1074..1103
FT /evidence="ECO:0000255"
FT COILED 2897..2982
FT /evidence="ECO:0000255"
FT COILED 3109..3200
FT /evidence="ECO:0000255"
FT COILED 3408..3442
FT /evidence="ECO:0000255"
FT BINDING 145..152
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT BINDING 1689..1696
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT BINDING 1979..1986
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT BINDING 2291..2298
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT BINDING 2655..2662
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT VAR_SEQ 736..4122
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_031282"
FT VAR_SEQ 3273
FT /note="Q -> QIIGLKSW (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_031283"
FT VARIANT 209
FT /note="F -> I (in SRTD3; dbSNP:rs771511132)"
FT /evidence="ECO:0000269|PubMed:19361615"
FT /id="VAR_063242"
FT VARIANT 302
FT /note="T -> P (in dbSNP:rs12803695)"
FT /id="VAR_038862"
FT VARIANT 304
FT /note="Q -> L (in dbSNP:rs12146610)"
FT /id="VAR_038863"
FT VARIANT 330
FT /note="R -> C (in SRTD3; dbSNP:rs397514637)"
FT /evidence="ECO:0000269|PubMed:22499340,
FT ECO:0000269|PubMed:23456818"
FT /id="VAR_069591"
FT VARIANT 338
FT /note="R -> G (in SRTD3; dbSNP:rs1322077043)"
FT /evidence="ECO:0000269|PubMed:22499340"
FT /id="VAR_069592"
FT VARIANT 341
FT /note="H -> Y (in dbSNP:rs17301182)"
FT /id="VAR_038864"
FT VARIANT 430
FT /note="R -> C (in SRTD3; dbSNP:rs374073337)"
FT /evidence="ECO:0000269|PubMed:22499340"
FT /id="VAR_069593"
FT VARIANT 456
FT /note="R -> Q (in dbSNP:rs17099969)"
FT /id="VAR_038865"
FT VARIANT 495
FT /note="K -> R (in SRTD3)"
FT /evidence="ECO:0000269|PubMed:22499340"
FT /id="VAR_069594"
FT VARIANT 587
FT /note="R -> C (in SRTD3; dbSNP:rs137853030)"
FT /evidence="ECO:0000269|PubMed:19361615"
FT /id="VAR_063243"
FT VARIANT 789
FT /note="R -> K (in dbSNP:rs7358374)"
FT /id="VAR_038866"
FT VARIANT 871
FT /note="L -> P (in SRTD3)"
FT /evidence="ECO:0000269|PubMed:23456818"
FT /id="VAR_069595"
FT VARIANT 1221
FT /note="R -> K (in dbSNP:rs12794914)"
FT /id="VAR_038867"
FT VARIANT 1228
FT /note="L -> I (in SRTD3; unknown pathological significance;
FT dbSNP:rs189806840)"
FT /evidence="ECO:0000269|PubMed:23456818"
FT /id="VAR_069596"
FT VARIANT 1240
FT /note="I -> T (in SRTD3; dbSNP:rs137853028)"
FT /evidence="ECO:0000269|PubMed:19442771,
FT ECO:0000269|PubMed:23456818"
FT /id="VAR_063244"
FT VARIANT 1288
FT /note="T -> A (in dbSNP:rs17301750)"
FT /id="VAR_038868"
FT VARIANT 1379
FT /note="M -> V (in SRTD3)"
FT /evidence="ECO:0000269|PubMed:23456818"
FT /id="VAR_069597"
FT VARIANT 1413
FT /note="K -> R (in dbSNP:rs688906)"
FT /evidence="ECO:0000269|PubMed:8666668"
FT /id="VAR_038869"
FT VARIANT 1423
FT /note="R -> C (in SRTD3; dbSNP:rs745870321)"
FT /evidence="ECO:0000269|PubMed:22499340"
FT /id="VAR_069598"
FT VARIANT 1442
FT /note="G -> D (in SRTD3; dbSNP:rs763571787)"
FT /evidence="ECO:0000269|PubMed:23456818"
FT /id="VAR_069599"
FT VARIANT 1537
FT /note="Q -> R (in SRTD3; dbSNP:rs137853033)"
FT /id="VAR_063245"
FT VARIANT 1987
FT /note="T -> A (in SRTD3; dbSNP:rs137853035)"
FT /evidence="ECO:0000269|PubMed:19442771"
FT /id="VAR_063246"
FT VARIANT 1991
FT /note="M -> K (in SRTD3; dbSNP:rs1202784860)"
FT /evidence="ECO:0000269|PubMed:23456818"
FT /id="VAR_069600"
FT VARIANT 1991
FT /note="M -> L (in SRTD3; dbSNP:rs137853025)"
FT /evidence="ECO:0000269|PubMed:19442771"
FT /id="VAR_063247"
FT VARIANT 2205
FT /note="R -> H (in SRTD3; dbSNP:rs137853031)"
FT /evidence="ECO:0000269|PubMed:19361615"
FT /id="VAR_063248"
FT VARIANT 2227
FT /note="M -> V (in SRTD3; dbSNP:rs750249486)"
FT /evidence="ECO:0000269|PubMed:23456818"
FT /id="VAR_069601"
FT VARIANT 2304
FT /note="A -> T (in SRTD3; dbSNP:rs747348765)"
FT /evidence="ECO:0000269|PubMed:23456818"
FT /id="VAR_069602"
FT VARIANT 2362
FT /note="N -> S (in SRTD3)"
FT /evidence="ECO:0000269|PubMed:23456818"
FT /id="VAR_069603"
FT VARIANT 2461
FT /note="G -> V (in SRTD3; dbSNP:rs137853034)"
FT /evidence="ECO:0000269|PubMed:19442771"
FT /id="VAR_063249"
FT VARIANT 2481
FT /note="R -> Q (in SRTD3; dbSNP:rs781326398)"
FT /evidence="ECO:0000269|PubMed:23456818"
FT /id="VAR_069604"
FT VARIANT 2496
FT /note="P -> S (in SRTD3; dbSNP:rs397514636)"
FT /evidence="ECO:0000269|PubMed:22499340"
FT /id="VAR_069605"
FT VARIANT 2532
FT /note="R -> W (in SRTD3; dbSNP:rs1350329646)"
FT /evidence="ECO:0000269|PubMed:23456818"
FT /id="VAR_069606"
FT VARIANT 2555
FT /note="V -> M (in SRTD3; dbSNP:rs746195428)"
FT /evidence="ECO:0000269|PubMed:23456818"
FT /id="VAR_069607"
FT VARIANT 2573
FT /note="Y -> C (in SRTD3; dbSNP:rs1278825521)"
FT /evidence="ECO:0000269|PubMed:23456818"
FT /id="VAR_069608"
FT VARIANT 2640
FT /note="I -> T (in SRTD3; dbSNP:rs1265669915)"
FT /evidence="ECO:0000269|PubMed:23456818"
FT /id="VAR_069609"
FT VARIANT 2662
FT /note="R -> Q (in SRTD3; dbSNP:rs397514635)"
FT /evidence="ECO:0000269|PubMed:22499340"
FT /id="VAR_069610"
FT VARIANT 2819
FT /note="I -> M (in SRTD3; dbSNP:rs1060501431)"
FT /evidence="ECO:0000269|PubMed:23456818"
FT /id="VAR_069611"
FT VARIANT 2871
FT /note="R -> Q (in dbSNP:rs589623)"
FT /evidence="ECO:0000269|PubMed:12056414,
FT ECO:0000269|PubMed:17974005"
FT /id="VAR_038870"
FT VARIANT 3015
FT /note="D -> G (in SRTD3; dbSNP:rs137853027)"
FT /evidence="ECO:0000269|PubMed:19442771,
FT ECO:0000269|PubMed:23456818"
FT /id="VAR_063250"
FT VARIANT 3381
FT /note="P -> L (in SRTD3; dbSNP:rs368631447)"
FT /evidence="ECO:0000269|PubMed:23456818"
FT /id="VAR_069612"
FT VARIANT 3680
FT /note="A -> V (in dbSNP:rs10895391)"
FT /evidence="ECO:0000269|PubMed:12056414"
FT /id="VAR_038871"
FT VARIANT 3762
FT /note="L -> V (in SRTD3)"
FT /evidence="ECO:0000269|PubMed:19442771"
FT /id="VAR_063251"
FT VARIANT 3806
FT /note="R -> C (in SRTD3; dbSNP:rs754753584)"
FT /evidence="ECO:0000269|PubMed:23456818"
FT /id="VAR_069613"
FT VARIANT 3847
FT /note="W -> G (in SRTD3; dbSNP:rs752554582)"
FT /evidence="ECO:0000269|PubMed:23456818"
FT /id="VAR_069614"
FT VARIANT 3909
FT /note="G -> D (probable disease-associated variant found in
FT short rib-polydactyly syndrome 3/6; digenic inheritance;
FT the patient also carries a mutation in NEK1;
FT dbSNP:rs201479015)"
FT /evidence="ECO:0000269|PubMed:21211617"
FT /id="VAR_069615"
FT VARIANT 3976
FT /note="S -> N (in dbSNP:rs4754914)"
FT /id="VAR_038872"
FT VARIANT 4139
FT /note="Q -> P (in dbSNP:rs1793493)"
FT /id="VAR_038873"
FT VARIANT 4232
FT /note="L -> R (in SRTD3)"
FT /evidence="ECO:0000269|PubMed:23456818"
FT /id="VAR_069616"
FT CONFLICT 174
FT /note="D -> G (in Ref. 1; BAE17138)"
FT /evidence="ECO:0000305"
FT CONFLICT 178
FT /note="F -> L (in Ref. 1; BAE17138)"
FT /evidence="ECO:0000305"
FT CONFLICT 594
FT /note="F -> L (in Ref. 1; BAE17138)"
FT /evidence="ECO:0000305"
FT CONFLICT 1120
FT /note="I -> N (in Ref. 4; AAB09728)"
FT /evidence="ECO:0000305"
FT CONFLICT 1168
FT /note="D -> V (in Ref. 4; AAB09728)"
FT /evidence="ECO:0000305"
FT CONFLICT 1784
FT /note="N -> H (in Ref. 6; CAB06054)"
FT /evidence="ECO:0000305"
FT CONFLICT 1864
FT /note="W -> Y (in Ref. 6; CAB06054)"
FT /evidence="ECO:0000305"
FT CONFLICT 1866..1867
FT /note="LR -> FS (in Ref. 6; CAB06054)"
FT /evidence="ECO:0000305"
FT CONFLICT 1930
FT /note="E -> K (in Ref. 1; BAE46899)"
FT /evidence="ECO:0000305"
FT CONFLICT 3095
FT /note="A -> V (in Ref. 7; CAD98012)"
FT /evidence="ECO:0000305"
FT CONFLICT 3665
FT /note="L -> P (in Ref. 7; CAD98012)"
FT /evidence="ECO:0000305"
FT CONFLICT 4258
FT /note="C -> R (in Ref. 3; BAB13905)"
FT /evidence="ECO:0000305"
FT HELIX 1257..1273
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 1278..1281
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 1289..1292
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 1295..1314
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 1316..1321
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 1322..1358
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 1362..1384
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 1389..1392
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 1397..1425
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 1427..1431
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 1434..1442
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 1447..1454
FT /evidence="ECO:0007829|PDB:4RH7"
FT TURN 1455..1457
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 1458..1460
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 1462..1464
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 1475..1477
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 1483..1485
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 1496..1523
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 1524..1526
FT /evidence="ECO:0007829|PDB:4RH7"
FT TURN 1531..1533
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 1536..1557
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 1561..1580
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 1583..1586
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 1593..1616
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 1624..1628
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 1631..1634
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 1640..1644
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 1647..1650
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 1666..1681
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 1684..1688
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 1695..1705
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 1710..1714
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 1721..1734
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 1737..1742
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 1748..1767
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 1770..1774
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 1777..1780
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 1786..1791
FT /evidence="ECO:0007829|PDB:4RH7"
FT TURN 1796..1798
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 1806..1809
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 1812..1816
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 1823..1833
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 1838..1855
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 1866..1886
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 1891..1906
FT /evidence="ECO:0007829|PDB:4RH7"
FT TURN 1907..1909
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 1912..1925
FT /evidence="ECO:0007829|PDB:4RH7"
FT TURN 1927..1929
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 1938..1950
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 1956..1971
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 1973..1978
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 1985..1999
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 2004..2008
FT /evidence="ECO:0007829|PDB:4RH7"
FT TURN 2010..2012
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2015..2019
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 2021..2023
FT /evidence="ECO:0007829|PDB:4RH7"
FT TURN 2024..2027
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 2028..2030
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2033..2043
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 2050..2056
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2060..2063
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2064..2066
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2067..2070
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 2071..2073
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 2090..2097
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2104..2109
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 2110..2114
FT /evidence="ECO:0007829|PDB:4RH7"
FT TURN 2117..2119
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2122..2132
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2138..2159
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2168..2177
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2185..2197
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2202..2215
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 2216..2218
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2226..2228
FT /evidence="ECO:0007829|PDB:4RH7"
FT TURN 2233..2235
FT /evidence="ECO:0007829|PDB:4RH7"
FT TURN 2251..2254
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 2256..2259
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2266..2279
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2281..2283
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 2287..2290
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2297..2307
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 2312..2316
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2324..2332
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 2341..2343
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 2348..2350
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 2352..2359
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2373..2384
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 2385..2388
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 2390..2392
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 2394..2397
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 2401..2406
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2419..2422
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 2425..2429
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2435..2452
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 2455..2461
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2463..2483
FT /evidence="ECO:0007829|PDB:4RH7"
FT TURN 2486..2488
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2496..2504
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2505..2508
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2520..2534
FT /evidence="ECO:0007829|PDB:4RH7"
FT TURN 2535..2538
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2542..2559
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 2560..2562
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 2571..2577
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2579..2581
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 2599..2603
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2604..2621
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2631..2645
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 2651..2654
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2661..2672
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 2675..2677
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2687..2702
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 2708..2713
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2714..2716
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2721..2732
FT /evidence="ECO:0007829|PDB:4RH7"
FT TURN 2736..2738
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2741..2758
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2764..2775
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 2776..2782
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 2784..2786
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2789..2795
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2798..2802
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 2803..2807
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2813..2825
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2849..2862
FT /evidence="ECO:0007829|PDB:4RH7"
FT TURN 2863..2865
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2869..2994
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 2998..3004
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3011..3023
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3031..3038
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3043..3046
FT /evidence="ECO:0007829|PDB:4RH7"
FT TURN 3047..3049
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3057..3070
FT /evidence="ECO:0007829|PDB:4RH7"
FT TURN 3071..3073
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3076..3080
FT /evidence="ECO:0007829|PDB:4RH7"
FT TURN 3084..3087
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3088..3197
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3200..3214
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3219..3233
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3240..3244
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3247..3255
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3262..3270
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 3275..3281
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3286..3295
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 3301..3303
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3310..3320
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 3324..3327
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3334..3336
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3337..3340
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 3344..3347
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 3350..3355
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 3358..3362
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 3370..3375
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3381..3384
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 3387..3391
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3396..3411
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3413..3446
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 3447..3449
FT /evidence="ECO:0007829|PDB:4RH7"
FT TURN 3451..3453
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3455..3490
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3493..3512
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3520..3532
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3540..3562
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3565..3579
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 3582..3584
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3588..3593
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 3616..3618
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3620..3632
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3634..3640
FT /evidence="ECO:0007829|PDB:4RH7"
FT TURN 3641..3644
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3647..3653
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3658..3660
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3663..3668
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3673..3681
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3683..3698
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3710..3714
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 3723..3726
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3734..3744
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 3751..3754
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3759..3773
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 3776..3780
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3782..3784
FT /evidence="ECO:0007829|PDB:4RH7"
FT TURN 3786..3788
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3789..3798
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 3806..3811
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3819..3823
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 3824..3829
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3836..3846
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3849..3852
FT /evidence="ECO:0007829|PDB:4RH7"
FT TURN 3855..3860
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3861..3877
FT /evidence="ECO:0007829|PDB:4RH7"
FT TURN 3881..3884
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3893..3908
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 3909..3911
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3916..3925
FT /evidence="ECO:0007829|PDB:4RH7"
FT TURN 3928..3930
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3934..3948
FT /evidence="ECO:0007829|PDB:4RH7"
FT TURN 3967..3969
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3977..3986
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 3993..3996
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 4001..4020
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 4031..4036
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 4041..4051
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 4055..4059
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 4071..4102
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 4109..4120
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 4125..4130
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 4137..4159
FT /evidence="ECO:0007829|PDB:4RH7"
FT TURN 4163..4165
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 4170..4172
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 4176..4191
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 4195..4197
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 4198..4202
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 4204..4206
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 4212..4217
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 4221..4228
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 4231..4233
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 4237..4239
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 4241..4244
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 4248..4254
FT /evidence="ECO:0007829|PDB:4RH7"
FT TURN 4263..4265
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 4266..4276
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 4279..4287
FT /evidence="ECO:0007829|PDB:4RH7"
FT HELIX 4292..4298
FT /evidence="ECO:0007829|PDB:4RH7"
FT STRAND 4301..4303
FT /evidence="ECO:0007829|PDB:4RH7"
SQ SEQUENCE 4307 AA; 492622 MW; 54B60DEE419B7E9D CRC64;
MANGTADVRK LFIFTTTQNY FGLMSELWDQ PLLCNCLEIN NFLDDGNQML LRVQRSDAGI
SFSNTIEFGD TKDKVLVFFK LRPEVITDEN LHDNILVSSM LESPISSLYQ AVRQVFAPML
LKDQEWSRNF DPKLQNLLSE LEAGLGIVLR RSDTNLTKLK FKEDDTRGIL TPSDEFQFWI
EQAHRGNKQI SKERANYFKE LFETIAREFY NLDSLSLLEV VDLVETTQDV VDDVWRQTEH
DHYPESRMLH LLDIIGGSFG RFVQKKLGTL NLWEDPYYLV KESLKAGISI CEQWVIVCNH
LTGQVWQRYV PHPWKNEKYF PETLDKLGKR LEEVLAIRTI HEKFLYFLPA SEEKIICLTR
VFEPFTGLNP VQYNPYTEPL WKAAVSQYEK IIAPAEQKIA GKLKNYISEI QDSPQQLLQA
FLKYKELVKR PTISKELMLE RETLLARLVD SIKDFRLDFE NRCRGIPGDA SGPLSGKNLS
EVVNSIVWVR QLELKVDDTI KIAEALLSDL PGFRCFHQSA KDLLDQLKLY EQEQFDDWSR
DIQSGLSDSR SGLCIEASSR IMELDSNDGL LKVHYSDRLV ILLREVRQLS ALGFVIPAKI
QQVANIAQKF CKQAIILKQV AHFYNSIDQQ MIQSQRPMML QSALAFEQII KNSKAGSGGK
SQITWDNPKE LEGYIQKLQN AAERLATENR KLRKWHTTFC EKVVVLMNID LLRQQQRWKD
GLQELRTGLA TVEAQGFQAS DMHAWKQHWN HQLYKALEHQ YQMGLEALNE NLPEINIDLT
YKQGRLQFRP PFEEIRAKYY REMKRFIGIP NQFKGVGEAG DESIFSIMID RNASGFLTIF
SKAEDLFRRL SAVLHQHKEW IVIGQVDMEA LVEKHLFTVH DWEKNFKALK IKGKEVERLP
SAVKVDCLNI NCNPVKTVID DLIQKLFDLL VLSLKKSIQA HLHEIDTFVT EAMEVLTIMP
QSVEEIGDAN LQYSKLQERK PEILPLFQEA EDKNRLLRTV AGGGLETISN LKAKWDKFEL
MMESHQLMIK DQIEVMKGNV KSRLQIYYQE LEKFKARWDQ LKPGDDVIET GQHNTLDKSA
KLIKEKKIEF DDLEVTRKKL VDDCHHFRLE EPNFSLASSI SKDIESCAQI WAFYEEFQQG
FQEMANEDWI TFRTKTYLFE EFLMNWHDRL RKVEEHSVMT VKLQSEVDKY KIVIPILKYV
RGEHLSPDHW LDLFRLLGLP RGTSLEKLLF GDLLRVADTI VAKAADLKDL NSRAQGEVTI
REALRELDLW GVGAVFTLID YEDSQSRTMK LIKDWKDIVN QVGDNRCLLQ SLKDSPYYKG
FEDKVSIWER KLAELDEYLQ NLNHIQRKWV YLEPIFGRGA LPKEQTRFNR VDEDFRSIMT
DIKKDNRVTT LTTHAGIRNS LLTILDQLQR CQKSLNEFLE EKRSAFPRFY FIGDDDLLEI
LGQSTNPSVI QSHLKKLFAG INSVCFDEKS KHITAMKSLE GEVVPFKNKV PLSNNVETWL
NDLALEMKKT LEQLLKECVT TGRSSQGAVD PSLFPSQILC LAEQIKFTED VENAIKDHSL
HQIETQLVNK LEQYTNIDTS SEDPGNTESG ILELKLKALI LDIIHNIDVV KQLNQIQVHT
TEDWAWKKQL RFYMKSDHTC CVQMVDSEFQ YTYEYQGNAS KLVYTPLTDK CYLTLTQAMK
MGLGGNPYGP AGTGKTESVK ALGGLLGRQV LVFNCDEGID VKSMGRIFVG LVKCGAWGCF
DEFNRLEESV LSAVSMQIQT IQDALKNHRT VCELLGKEVE VNSNSGIFIT MNPAGKGYGG
RQKLPDNLKQ LFRPVAMSHP DNELIAEVIL YSEGFKDAKV LSRKLVAIFN LSRELLTPQQ
HYDWGLRALK TVLRGSGNLL RQLNKSGTTQ NANESHIVVQ ALRLNTMSKF TFTDCTRFDA
LIKDVFPGIE LKEVEYDELS AALKQVFEEA NYEIIPNQIK KALELYEQLC QRMGVVIVGP
SGAGKSTLWR MLRAALCKTG KVVKQYTMNP KAMPRYQLLG HIDMDTREWS DGVLTNSARQ
VVREPQDVSS WIICDGDIDP EWIESLNSVL DDNRLLTMPS GERIQFGPNV NFVFETHDLS
CASPATISRM GMIFLSDEET DLNSLIKSWL RNQPAEYRNN LENWIGDYFE KALQWVLKQN
DYVVETSLVG TVMNGLSHLH GCRDHDEFII NLIRGLGGNL NMKSRLEFTK EVFHWARESP
PDFHKPMDTY YDSTRGRLAT YVLKKPEDLT ADDFSNGLTL PVIQTPDMQR GLDYFKPWLS
SDTKQPFILV GPEGCGKGML LRYAFSQLRS TQIATVHCSA QTTSRHLLQK LSQTCMVIST
NTGRVYRPKD CERLVLYLKD INLPKLDKWG TSTLVAFLQQ VLTYQGFYDE NLEWVGLENI
QIVASMSAGG RLGRHKLTTR FTSIVRLCSI DYPEREQLQT IYGAYLEPVL HKNLKNHSIW
GSSSKIYLLA GSMVQVYEQV RAKFTVDDYS HYFFTPCILT QWVLGLFRYD LEGGSSNHPL
DYVLEIVAYE ARRLFRDKIV GAKELHLFDI ILTSVFQGDW GSDILDNMSD SFYVTWGARH
NSGARAAPGQ PLPPHGKPLG KLNSTDLKDV IKKGLIHYGR DNQNLDILLF HEVLEYMSRI
DRVLSFPGGS LLLAGRSGVG RRTITSLVSH MHGAVLFSPK ISRGYELKQF KNDLKHVLQL
AGIEAQQVVL LLEDYQFVHP TFLEMINSLL SSGEVPGLYT LEELEPLLLP LKDQASQDGF
FGPVFNYFTY RIQQNLHIVL IMDSANSNFM INCESNPALH KKCQVLWMEG WSNSSMKKIP
EMLFSETGGG EKYNDKKRKE EKKKNSVDPD FLKSFLLIHE SCKAYGATPS RYMTFLHVYS
AISSSKKKEL LKRQSHLQAG VSKLNEAKAL VDELNRKAGE QSVLLKTKQD EADAALQMIT
VSMQDASEQK TELERLKHRI AEEVVKIEER KNKIDDELKE VQPLVNEAKL AVGNIKPESL
SEIRSLRMPP DVIRDILEGV LRLMGIFDTS WVSMKSFLAK RGVREDIATF DARNISKEIR
ESVEELLFKN KGSFDPKNAK RASTAAAPLA AWVKANIQYS HVLERIHPLE TEQAGLESNL
KKTEDRKRKL EELLNSVGQK VSELKEKFQS RTSEAAKLEA EVSKAQETIK AAEVLINQLD
REHKRWNAQV VEITEELATL PKRAQLAAAF ITYLSAAPES LRKTCLEEWT KSAGLEKFDL
RRFLCTESEQ LIWKSEGLPS DDLSIENALV ILQSRVCPFL IDPSSQATEW LKTHLKDSRL
EVINQQDSNF ITALELAVRF GKTLIIQEMD GVEPVLYPLL RRDLVAQGPR YVVQIGDKII
DYNEEFRLFL STRNPNPFIP PDAASIVTEV NFTTTRSGLR GQLLALTIQH EKPDLEEQKT
KLLQQEEDKK IQLAKLEESL LETLATSQGN ILENKDLIES LNQTKASSAL IQESLKESYK
LQISLDQERD AYLPLAESAS KMYFIISDLS KINNMYRFSL AAFLRLFQRA LQNKQDSENT
EQRIQSLISS LQHMVYEYIC RCLFKADQLM FALHFVRGMH PELFQENEWD TFTGVVVGDM
LRKADSQQKI RDQLPSWIDQ ERSWAVATLK IALPSLYQTL CFEDAALWRT YYNNSMCEQE
FPSILAKKVS LFQQILVVQA LRPDRLQSAM ALFACKTLGL KEVSPLPLNL KRLYKETLEI
EPILIIISPG ADPSQELQEL ANAERSGECY HQVAMGQGQA DLAIQMLKEC ARNGDWLCLK
NLHLVVSWLP VLEKELNTLQ PKDTFRLWLT AEVHPNFTPI LLQSSLKITY ESPPGLKKNL
MRTYESWTPE QISKKDNTHR AHALFSLAWF HAACQERRNY IPQGWTKFYE FSLSDLRAGY
NIIDRLFDGA KDVQWEFVHG LLENAIYGGR IDNYFDLRVL QSYLKQFFNS SVIDVFNQRN
KKSIFPYSVS LPQSCSILDY RAVIEKIPED DKPSFFGLPA NIARSSQRMI SSQVISQLRI
LGRSITAGSK FDREIWSNEL SPVLNLWKKL NQNSNLIHQK VPPPNDRQGS PILSFIILEQ
FNAIRLVQSV HQSLAALSKV IRGTTLLSSE VQKLASALLN QKCPLAWQSK WEGPEDPLQY
LRGLVARALA IQNWVDKAEK QALLSETLDL SELFHPDTFL NALRQETARA VGRSVDSLKF
VASWKGRLQE AKLQIKISGL LLEGCSFDGN QLSENQLDSP SVSSVLPCFM GWIPQDACGP
YSPDECISLP VYTSAERDRV VTNIDVPCGG NQDQWIQCGA ALFLKNQ
