DYHC_DICDI
ID DYHC_DICDI Reviewed; 4730 AA.
AC P34036; Q551T4; Q8T128;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Dynein heavy chain, cytoplasmic;
DE AltName: Full=Dynein heavy chain, cytosolic;
DE Short=DYHC;
GN Name=dhcA; ORFNames=DDB_G0276355;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=AX3;
RX PubMed=1469051; DOI=10.1083/jcb.119.6.1597;
RA Koonce M.P., Grissom P.M., McIntosh J.R.;
RT "Dynein from Dictyostelium: primary structure comparisons between a
RT cytoplasmic motor enzyme and flagellar dynein.";
RL J. Cell Biol. 119:1597-1604(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [4]
RP CHARACTERIZATION.
RX PubMed=7866389; DOI=10.1111/j.1550-7408.1994.tb01528.x;
RA Koonce M.P., Grissom P.M., Lyon M., Pope T., McIntosh J.R.;
RT "Molecular characterization of a cytoplasmic dynein from Dictyostelium.";
RL J. Eukaryot. Microbiol. 41:645-651(1994).
CC -!- FUNCTION: Cytoplasmic dynein acts as a motor for the intracellular
CC retrograde motility of vesicles and organelles along microtubules.
CC Dynein has ATPase activity; the force-producing power stroke is thought
CC to occur on release of ADP.
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC -!- DOMAIN: Dynein heavy chains probably consist of an N-terminal stem
CC (which binds cargo and interacts with other dynein components), and the
CC head or motor domain. The motor contains six tandemly-linked AAA
CC domains in the head, which form a ring. A stalk-like structure (formed
CC by two of the coiled coil domains) protrudes between AAA 4 and AAA 5
CC and terminates in a microtubule-binding site. A seventh domain may also
CC contribute to this ring; it is not clear whether the N-terminus or the
CC C-terminus forms this extra domain. There are four well-conserved and
CC two non-conserved ATPase sites, one per AAA domain. Probably only one
CC of these (within AAA 1) actually hydrolyzes ATP, the others may serve a
CC regulatory function.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA78827.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; Z15124; CAA78827.1; ALT_FRAME; mRNA.
DR EMBL; AAFI02000014; EAL69258.1; -; Genomic_DNA.
DR PIR; A44357; A44357.
DR RefSeq; XP_643185.1; XM_638093.1.
DR PDB; 3J6P; EM; 8.20 A; D=3382-3489.
DR PDB; 3VKG; X-ray; 2.81 A; A/B=1388-3371, A/B=3496-4730.
DR PDB; 3VKH; X-ray; 3.80 A; A/B=1388-4730.
DR PDBsum; 3J6P; -.
DR PDBsum; 3VKG; -.
DR PDBsum; 3VKH; -.
DR BMRB; P34036; -.
DR SMR; P34036; -.
DR DIP; DIP-59087N; -.
DR STRING; 44689.DDB0185096; -.
DR TCDB; 1.I.1.1.5; the nuclear pore complex (npc) family.
DR PaxDb; P34036; -.
DR PRIDE; P34036; -.
DR EnsemblProtists; EAL69258; EAL69258; DDB_G0276355.
DR GeneID; 8620457; -.
DR KEGG; ddi:DDB_G0276355; -.
DR dictyBase; DDB_G0276355; dhcA.
DR eggNOG; KOG3595; Eukaryota.
DR HOGENOM; CLU_000038_7_0_1; -.
DR InParanoid; P34036; -.
DR OMA; FIMDEAN; -.
DR PhylomeDB; P34036; -.
DR BRENDA; 5.6.1.2; 1939.
DR Reactome; R-DDI-6798695; Neutrophil degranulation.
DR Reactome; R-DDI-6807878; COPI-mediated anterograde transport.
DR PRO; PR:P34036; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:1904949; C:ATPase complex; IDA:dictyBase.
DR GO; GO:0005938; C:cell cortex; IDA:dictyBase.
DR GO; GO:0005813; C:centrosome; IDA:dictyBase.
DR GO; GO:0005737; C:cytoplasm; IDA:dictyBase.
DR GO; GO:0005868; C:cytoplasmic dynein complex; IDA:dictyBase.
DR GO; GO:0005881; C:cytoplasmic microtubule; IBA:GO_Central.
DR GO; GO:0030286; C:dynein complex; IBA:GO_Central.
DR GO; GO:0036186; C:early phagosome membrane; IDA:dictyBase.
DR GO; GO:0030139; C:endocytic vesicle; IDA:dictyBase.
DR GO; GO:0005874; C:microtubule; IDA:dictyBase.
DR GO; GO:0061474; C:phagolysosome membrane; IDA:dictyBase.
DR GO; GO:0005524; F:ATP binding; IDA:dictyBase.
DR GO; GO:0043273; F:CTPase activity; IDA:dictyBase.
DR GO; GO:0045505; F:dynein intermediate chain binding; IPI:FlyBase.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IPI:dictyBase.
DR GO; GO:0008017; F:microtubule binding; IDA:dictyBase.
DR GO; GO:0003777; F:microtubule motor activity; IDA:dictyBase.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IDA:dictyBase.
DR GO; GO:0015631; F:tubulin binding; IDA:dictyBase.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IMP:dictyBase.
DR GO; GO:0051293; P:establishment of spindle localization; IBA:GO_Central.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR GO; GO:0072382; P:minus-end-directed vesicle transport along microtubule; IDA:dictyBase.
DR GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0090307; P:mitotic spindle assembly; IMP:dictyBase.
DR GO; GO:0007097; P:nuclear migration; IBA:GO_Central.
DR GO; GO:0090382; P:phagosome maturation; IDA:dictyBase.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.10.8.720; -; 1.
DR Gene3D; 1.20.140.100; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 3.20.180.20; -; 1.
DR Gene3D; 3.40.50.300; -; 5.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; SSF52540; 4.
PE 1: Evidence at protein level;
KW 3D-structure; ATP-binding; Coiled coil; Cytoplasm; Cytoskeleton; Dynein;
KW Microtubule; Motor protein; Nucleotide-binding; Reference proteome; Repeat.
FT CHAIN 1..4730
FT /note="Dynein heavy chain, cytoplasmic"
FT /id="PRO_0000114635"
FT REGION 1..1935
FT /note="Stem"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 91..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 964..1016
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1936..2158
FT /note="AAA 1"
FT REGION 2238..2531
FT /note="AAA 2"
FT REGION 2437..2486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2635..2885
FT /note="AAA 3"
FT REGION 2978..3252
FT /note="AAA 4"
FT REGION 3271..3585
FT /note="Stalk"
FT REGION 3638..3867
FT /note="AAA 5"
FT REGION 4098..4312
FT /note="AAA 6"
FT REGION 4432..4465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 867..900
FT /evidence="ECO:0000255"
FT COILED 1204..1224
FT /evidence="ECO:0000255"
FT COILED 1343..1372
FT /evidence="ECO:0000255"
FT COILED 1425..1441
FT /evidence="ECO:0000255"
FT COILED 1661..1689
FT /evidence="ECO:0000255"
FT COILED 2231..2253
FT /evidence="ECO:0000255"
FT COILED 2442..2462
FT /evidence="ECO:0000255"
FT COILED 3271..3349
FT /evidence="ECO:0000255"
FT COILED 3483..3585
FT /evidence="ECO:0000255"
FT COILED 3854..3881
FT /evidence="ECO:0000255"
FT COMPBIAS 969..987
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 998..1016
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2451..2486
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 1974..1981
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT BINDING 2276..2283
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT BINDING 2674..2681
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT BINDING 3016..3023
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT CONFLICT 1604
FT /note="V -> L (in Ref. 1; CAA78827)"
FT /evidence="ECO:0000305"
FT CONFLICT 1616
FT /note="E -> Q (in Ref. 1; CAA78827)"
FT /evidence="ECO:0000305"
FT HELIX 1411..1416
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 1419..1421
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 1451..1464
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 1466..1470
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 1478..1487
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 1499..1504
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 1507..1540
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 1544..1548
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 1549..1551
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 1552..1556
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 1558..1574
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 1579..1582
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 1583..1586
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 1587..1618
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 1620..1624
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 1626..1628
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 1630..1652
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 1656..1659
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 1665..1692
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 1695..1699
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 1702..1710
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 1711..1713
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 1715..1717
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 1719..1724
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 1731..1734
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 1740..1745
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 1751..1763
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 1766..1792
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 1800..1808
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 1812..1831
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 1838..1862
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 1869..1893
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 1904..1907
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 1909..1914
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 1916..1921
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 1922..1924
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 1925..1929
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 1932..1935
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 1951..1965
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 1969..1973
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 1980..1990
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 1995..1999
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2006..2019
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 2022..2026
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 2027..2029
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2033..2052
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 2055..2057
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 2072..2075
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2081..2083
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2089..2092
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 2095..2099
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2105..2114
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 2115..2117
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2121..2137
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2149..2164
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2177..2201
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 2202..2206
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2209..2211
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2212..2222
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2234..2246
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2253..2266
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 2270..2275
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 2277..2281
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2282..2293
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 2294..2298
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 2300..2306
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 2308..2310
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2313..2317
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 2318..2320
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 2322..2324
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 2327..2329
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2331..2340
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 2343..2345
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2346..2348
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 2349..2357
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2361..2364
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 2365..2367
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2368..2371
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 2372..2374
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 2391..2398
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2405..2409
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 2411..2415
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2423..2434
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2441..2451
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2490..2506
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2511..2520
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2530..2554
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 2555..2557
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2562..2582
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2587..2598
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2612..2614
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 2615..2617
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 2619..2621
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 2623..2626
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 2639..2642
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2651..2665
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 2671..2675
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2680..2687
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2688..2690
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 2694..2699
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2707..2717
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 2718..2722
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 2728..2734
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 2738..2743
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 2744..2747
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2758..2769
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 2770..2774
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 2775..2778
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 2779..2792
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2805..2808
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 2813..2815
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2821..2835
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2840..2842
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2846..2863
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 2866..2868
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2876..2891
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2900..2913
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 2914..2916
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2920..2937
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2943..2946
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2965..2977
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 2992..3005
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 3012..3017
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3022..3032
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 3036..3038
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3048..3063
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 3069..3074
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3075..3077
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3082..3093
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 3102..3104
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3105..3118
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3126..3137
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 3138..3140
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 3143..3147
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 3152..3155
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3157..3160
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3163..3167
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 3168..3175
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3178..3188
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 3189..3191
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3203..3210
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3223..3247
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 3248..3250
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3257..3364
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3497..3600
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3602..3604
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3607..3624
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3634..3637
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3641..3649
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3656..3664
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 3672..3675
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3680..3688
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3690..3692
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 3699..3701
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3705..3714
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3731..3734
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 3762..3766
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3775..3779
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 3781..3785
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3790..3805
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3807..3818
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 3819..3824
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3825..3828
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 3829..3831
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3832..3839
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3845..3847
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3849..3885
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3887..3900
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3902..3905
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3913..3924
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3928..3930
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3936..3955
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 3956..3958
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3961..3963
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3966..3975
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 3976..3978
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3985..3993
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 3994..3997
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 3998..4000
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4006..4008
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 4009..4011
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4014..4026
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4028..4030
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4033..4039
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4041..4047
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4062..4069
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4075..4089
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4091..4093
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4094..4105
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 4108..4111
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4118..4124
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4143..4153
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4165..4181
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 4184..4186
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4190..4192
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 4194..4196
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4197..4205
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 4214..4216
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 4219..4221
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4227..4231
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 4233..4235
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4244..4252
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4257..4260
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 4262..4264
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4266..4283
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4284..4287
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 4288..4290
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4300..4317
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 4326..4328
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4331..4340
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 4341..4343
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 4349..4351
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4352..4363
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4366..4369
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 4370..4372
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 4374..4376
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4377..4379
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4389..4396
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4405..4408
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4414..4435
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 4436..4438
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4456..4464
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4496..4520
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4532..4543
FT /evidence="ECO:0007829|PDB:3VKG"
FT TURN 4548..4550
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4561..4580
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4591..4593
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4597..4611
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 4635..4639
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 4643..4646
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 4651..4655
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 4658..4663
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 4667..4669
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4682..4684
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 4685..4693
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 4699..4705
FT /evidence="ECO:0007829|PDB:3VKG"
FT HELIX 4713..4717
FT /evidence="ECO:0007829|PDB:3VKG"
FT STRAND 4722..4725
FT /evidence="ECO:0007829|PDB:3VKG"
SQ SEQUENCE 4730 AA; 539613 MW; 12B7133BEE7CCB7C CRC64;
MEDQQINVDS PTSGTNTPPV VTPTTSVISE QTLEETVKYL CKICPTLLDG DQSVFQNNLS
NQIPPENMNK LKKFISDSKI PVLLIQKTNP TINSSNQTST TTSSSSSSDD NTLTSSQQQS
KESFNFEIEV KFGGENKSTL AIVKRIPESI VEYSSNKSIA SQLQVLNLGD GSPMDTLHNY
IHNSVAPFVR SYILSASKDD ATTPSGGSAD KSITSQNLDK EMKQSIGAVN QKIAELEISL
YNCKQQVQIP EVTLAINPEI KSISKRLKET TGRTIKPDDL GDKASSPEFL NLLQAGTTTW
AKNIQNVTKH NLIENLPSDV STSQEINFWI ELETSLQNID QQLKSPEVEV TLATLRQAKR
FIASAPFETD TIGVRKAMDK VQSYKTLFKD FPITPLLTAT DLDSISSSVA AIFSHLKKTK
NPYYPIPRYL SFLEAIGRDM CNKVYQILRQ KNLMNIDYND FEHLNRSVRA LFTLWDDQFG
AFRDILRDLA KKRGNERIPL IVNIDNRIQL VIIKIGKFRK QHEDLKNVVS NVLPGSQLGG
GVVQTNTSNP TSPQKQEINA IEEINQAYLE FKEIDVLQLS KEGEEIWDAV VKRYNSRTDR
VETYITVKLR DRLATAKNAN EMFRVYQKFK DLLKRPKIRG ATHEYESQLI ERVKEDIRVL
HDKFKMQYNN SEAYYMSQLR DLPPVSGAII WARQIERQLD TYMKRVANVL GDSWESDAEG
QKLKSESDQF RHKLNTDHIF SKWADETEKR SFDISGRILT IVKRGNKLAL DINFDSHIIM
LFKEVRNLQW LGFRVPLKIS FISQGAKQVY PFAVSLKETL RTYAQTSGKV TPEFSTLVAS
YKRDVQANIT EGFRLKWETI PKVDPYVRKL STSINNFRDK VDDLIVKYSE IKKQLDGLKS
CPFKSESFNE IIANIQKVVD ELNLANYSNL PQWVTQLDAQ VESMLIERLI DAINSWVQLI
EGKEDQKDSQ STSGSSNKGG KLNRMNYSIR NKSDEENSSD LTQPQQSQQQ QQTISIKPKL
EKTIHEIVIR NQILSLSPPL EVARVNWIDQ LHSWLNICCD LPRIQSSRYD ESAMVHRGGV
DSKKQSTFRD MLPKLPQGSL ESAYSAITNK LEQVQQYVSI WLQYQSLWDM DSSFVYSKLG
DDLNKWQLLL NQIKKSRSTF DNSSTEKQFG PLTIDYTQVQ ASVNNKYDYW HKDILGHFGS
KLAEKMNQFY ETISSSRQEL EKLSVETVST EEAVHFIIQI QDMKKKLSSW EADLRYYRTG
QDLLQRQRFS FPNDWLDCER VEGEWSAFNE ILNRKNATIS EAIPQLQAKI LQESKSINDR
IKDFIDEWTA NKPLQGSIKH STALETLKIF EGRLIRLREE SDRLSKAKQA LDLTDTTGSS
SSDQDRLVPV EEEIQDLKAV WVELSNTWQE IDSLKETAWS AIIPRKVRKS LEDTLQKLKN
LPNRIRQYSA FDHAQNLIKI YLKGNAIITD LHSEAIKDRH WKILKKRLNT NWIITELTLG
SIWDSDLARN ENIYREVITA AQGEIALEEF LKGVREFWTT LELDLVNYQR KCKLVRGWDD
LFNKLAEHLN SISAMKMSPY YKVFEEEANH WDDRLNKVRS LLDVWIDVQR RWVYLEGIFS
GSGDINQLLP AESTRFKSIN SEFIAILKKV SGAPLILEVL AIERIQQTME RLSDLLGKVQ
KALGEYLERQ RSAFARFYFV GDEDLLEIIG NSKDIIKIQK HFRKMFAGLA NLTLDDEKTT
IIGMSSAEGE TVTFKKPISI ANGPKIHEWL TMVESEMKST LATLLSESLQ HFNQVDVNDH
SKYSEWVDNY PTQLVLLTSQ IVWSTQVDQA LGGGTLQQSK IQEQLQSIEQ TTQMILNNLA
DSVLQDLSAQ KRKKFEHLIT ELVHQRDVVR QLQKCKNLTG NKDFDWLYHM RYYYDATQEN
VLHKLVIHMA NATFYYGFEY LGIGERLVQT PLTDRCYLTL TQALESRMGG NPFGPAGTGK
TETVKALGSQ LGRFVLVFCC DEGFDLQAMS RIFVGLCQCG AWGCFDEFNR LEERILSAVS
QQIQTIQVAL KENSKEVELL GGKNISLHQD MGIFVTMNPG YAGRSNLPDN LKKLFRSMAM
IKPDREMIAQ VMLYSQGFKT AEVLAGKIVP LFKLCQEQLS AQSHYDFGLR ALKSVLVSAG
GIKRKCQPPQ LPPITDAESK TKADQIYCQY EIGVLLNSIN DTMIPKLVAD DIPLIQSLLL
DVFPGSQLQP IQMDQLRKKI QEIAKQRHLV TKQEWVEKIL QLHQILNINH GVMMVGPSGG
GKTTSWEVYL EAIEQVDNIK SEAHVMDPKA ITKDQLFGSL DLTTREWTDG LFTATLRRII
DNVRGESTKR HWIIFDGDVD PEWVENLNSL LDDNKLLTLP NGERLALPNN VRVMFEVQDL
KYATLATISR CGMVWFSEEI LTTQMIFQNY LDTLSNEPFD PQEKEQQKRN ENAQLQQQQQ
TTITSPILTS PPTTSSSSRS TTSTTSMIPA GLKVQKECAA IISQYFEPGG LVHKVLEDAG
QRPHIMDFTR LRVLNSFFSL MNRSIVNVIE YNQLHSDFPM SPENQSNYIT NRLLYSLMWG
LGGSMGLVER ENFSKFIQTI AITPVPANTI PLLDYSVSID DANWSLWKNK VPSVEVETHK
VASPDVVIPT VDTTRHVDVL HAWLSEHRPL ILCGPPGSGK TMTLTSTLRA FPDFEVVSLN
FSSATTPELL LKTFDHHCEY KRTPSGETVL RPTQLGKWLV VFCDEINLPS TDKYGTQRVI
TFIRQMVEKG GFWRTSDHTW IKLDKIQFVG ACNPPTDAGR VQLTHRFLRH APILLVDFPS
TSSLTQIYGT FNRALMKLLP NLRSFADNLT DAMVEFYSES QKRFTPDIQA HYIYSPRELS
RWDRALLEAI QTMDGCTLEG LVRLWAHEAL RLFQDRLVET EEKEWTDKKI DEVALKHFPS
VNLDALKRPI LYSNWLTKDY QPVNRSDLRE YVKARLKVFY EEELDVPLVL FNEVLDHILR
IDRVFRQPQG HALLIGVSGG GKSVLSRFVA WMNGLSIYTI KVNNNYKSSD FDDDLRMLLK
RAGCKEEKIC FIFDESNVLE SSFLERMNTL LAGGEVPGLF EGEEFTALMH ACKETAQRNG
LILDSEEELY KYFTSQVRRN LHVVFTMNPA SPDFHNRSAT SPALFNRCVL DWFGEWSPEA
LFQVGSEFTR NLDLENPQYI APPVFIQEAE IMGNNLMAIP PSHRDAVVSS LVYIHQTIGE
ANIRLLKRQG RQNYVTPRHY LDFINQVVLL INEKRDQLEE EQLHLNIGLK KLRDTEAQVK
DLQVSLAQKN RELDVKNEQA NQKLKQMVQD QQAAEIKQKD ARELQVQLDV RNKEIAVQKV
KAYADLEKAE PAIIEAQEAV STIKKKHLDE IKSLPKPPTP VKLAMEAVCL MLGGKKLEWA
DIRKKIMEPN FITSIINYDT KKMMTPKIRE AITKGYLEDP GFDYETVNRA SKACGPLVKW
ATAQTYYSEI LDRIKPLREE VEQLENAANE LKLKQDEIVA TITALEKSIA TYKEEYATLI
RETEQIKTES SKVKNKVDRS IALLDNLNSE RGRWEQQSEN FNTQMSTVVG DVVLASAFLA
YIGFFDQNFR TDLMRKWMIR LDSVGIKFKS DLSVPSFLSK PEERLNWHAN SLPSDELCIE
NAIMLKRFNR YPLVIDPSGQ AMEFLMNQYA DKKITKTSFL DSSFMKNLES ALRFGCPLLV
QDVENIDPVL NPVLNKEIRK KGGRILIRLG DQDVDFSPSF MIFLFTRDPT AHFTPDLCSR
VTFVNFTVTP SSLQSQCLHE ALKTERPDTH KKRSDLLKIQ GEFQVKLRIL EKSLLNALSQ
ASGNILDDDS VISTLETLKK ETTEIALKVE ETETVMQEIS EVSALYNPMA LSCSRVYFAM
EELSQFHLYQ FSLRAFLDIF YNLLNNNPNL VDKKDPNERL VYLSKDIFSM TFNRVTRTLL
NDDKLTFALQ LTIISVKGTS NEIEESEWDF LLKGGDNLTS IKETIPQLDS LLSTTQQKWL
ICLRQQVPSF SKLVDHIQQN SSDWKQFFGK DQVGEPIIPE SWIVAQAQLS NQQSTIVSNF
RKILLMKAFH SDRVLQYSHS FVCSVFGEDF LNTQELDMAN IVEKEVKSSS PLLLCSVPGY
DASSKVDDLA LQLHKQYKSF AIGSPEGFEL AEKSIYAAAK SGTWVLLKNI HLAPQWLVQL
EKKLHSLSPH PSFRLFMTSE IHPALPANLL RMSNVFSYEN PPGVKANLLH TFIGIPATRM
DKQPAERSRI YFLLAWFHAI IQERLRYIPL GWTKFFEFND ADLRGALDSI DYWVDLYSKG
RSNIDPDKIP WIAVRTILGS TIYGGRIDNE FDMRLLYSFL EQLFTPSAFN PDFPLVPSIG
LSVPEGTTRA HFMKWIEALP EISTPIWLGL PENAESLLLS NKARKMINDL QKMQSSEEDG
EDDQVSGSSK KESSSSSSED KGKAKLRATI TEWTKLLPKP LKQLKRTTQN IKDPLFRCFE
REISTGGKLV KKITNDLANL LELISGNIKS TNYLRSLTTS ISKGIVPKEW KWYSVPETIS
LSVWISDFSK RMQQLSEISE SSDYSSIQVW LGGLLNPEAY ITATRQSASQ LNGWSLENLR
LHASSLGKIS SEGGASFNVK GMALEGAVWN NDQLTPTDIL STPISIATLT WKDKDDPIFN
NSSSKLSVPV YLNETRSELL FSIDLPYDQS TSKQNWYQRS VSISSWKSDI
