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DYHC_HELCR
ID   DYHC_HELCR              Reviewed;        4466 AA.
AC   P39057;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Dynein beta chain, ciliary;
OS   Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Echinometridae;
OC   Heliocidaris.
OX   NCBI_TaxID=1043166;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 1192-1204 AND
RP   3324-3340.
RC   TISSUE=Egg, and Sperm;
RX   PubMed=1830928; DOI=10.1038/352643a0;
RA   Ogawa K.;
RT   "Four ATP-binding sites in the midregion of the beta heavy chain of
RT   dynein.";
RL   Nature 352:643-645(1991).
CC   -!- FUNCTION: Force generating protein of eukaryotic cilia and flagella.
CC       Produces force towards the minus ends of microtubules. Dynein has
CC       ATPase activity; the force-producing power stroke is thought to occur
CC       on release of ADP.
CC   -!- SUBUNIT: Consists of at least two heavy chains (alpha and beta), three
CC       intermediate chains and several light chains.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum. Cytoplasm,
CC       cytoskeleton, flagellum axoneme.
CC   -!- DOMAIN: Dynein heavy chains probably consist of an N-terminal stem
CC       (which binds cargo and interacts with other dynein components), and the
CC       head or motor domain. The motor contains six tandemly-linked AAA
CC       domains in the head, which form a ring. A stalk-like structure (formed
CC       by two of the coiled coil domains) protrudes between AAA 4 and AAA 5
CC       and terminates in a microtubule-binding site. A seventh domain may also
CC       contribute to this ring; it is not clear whether the N-terminus or the
CC       C-terminus forms this extra domain. There are four well-conserved and
CC       two non-conserved ATPase sites, one per AAA domain. Probably only one
CC       of these (within AAA 1) actually hydrolyzes ATP, the others may serve a
CC       regulatory function.
CC   -!- SIMILARITY: Belongs to the dynein heavy chain family. {ECO:0000305}.
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DR   EMBL; D01021; BAA00827.1; -; mRNA.
DR   PIR; S17231; S17231.
DR   SMR; P39057; -.
DR   PRIDE; P39057; -.
DR   GO; GO:0097729; C:9+2 motile cilium; IEA:UniProt.
DR   GO; GO:0005858; C:axonemal dynein complex; IEA:InterPro.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   GO; GO:0003341; P:cilium movement; IEA:InterPro.
DR   Gene3D; 1.10.8.710; -; 1.
DR   Gene3D; 1.10.8.720; -; 1.
DR   Gene3D; 1.20.140.100; -; 1.
DR   Gene3D; 3.10.490.20; -; 1.
DR   Gene3D; 3.20.180.20; -; 1.
DR   Gene3D; 3.40.50.300; -; 5.
DR   InterPro; IPR035699; AAA_6.
DR   InterPro; IPR035706; AAA_9.
DR   InterPro; IPR041658; AAA_lid_11.
DR   InterPro; IPR042219; AAA_lid_11_sf.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR041589; DNAH3_AAA_lid_1.
DR   InterPro; IPR030443; DNAH9-like.
DR   InterPro; IPR042222; Dynein_2_N.
DR   InterPro; IPR043157; Dynein_AAA1S.
DR   InterPro; IPR041466; Dynein_AAA5_ext.
DR   InterPro; IPR041228; Dynein_C.
DR   InterPro; IPR043160; Dynein_C_barrel.
DR   InterPro; IPR024743; Dynein_HC_stalk.
DR   InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR   InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR   InterPro; IPR013602; Dynein_heavy_linker.
DR   InterPro; IPR013594; Dynein_heavy_tail.
DR   InterPro; IPR042228; Dynein_linker_3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10676; PTHR10676; 1.
DR   PANTHER; PTHR10676:SF257; PTHR10676:SF257; 1.
DR   Pfam; PF12774; AAA_6; 1.
DR   Pfam; PF12780; AAA_8; 1.
DR   Pfam; PF12781; AAA_9; 1.
DR   Pfam; PF17857; AAA_lid_1; 1.
DR   Pfam; PF18198; AAA_lid_11; 1.
DR   Pfam; PF08385; DHC_N1; 1.
DR   Pfam; PF08393; DHC_N2; 1.
DR   Pfam; PF17852; Dynein_AAA_lid; 1.
DR   Pfam; PF18199; Dynein_C; 1.
DR   Pfam; PF03028; Dynein_heavy; 1.
DR   Pfam; PF12777; MT; 1.
DR   SUPFAM; SSF52540; SSF52540; 4.
PE   1: Evidence at protein level;
KW   ATP-binding; Cell projection; Cilium; Cilium biogenesis/degradation;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Direct protein sequencing; Dynein;
KW   Flagellum; Microtubule; Motor protein; Nucleotide-binding; Repeat.
FT   CHAIN           1..4466
FT                   /note="Dynein beta chain, ciliary"
FT                   /id="PRO_0000114644"
FT   REGION          1..1813
FT                   /note="Stem"
FT                   /evidence="ECO:0000250"
FT   REGION          1814..2035
FT                   /note="AAA 1"
FT                   /evidence="ECO:0000250"
FT   REGION          2095..2316
FT                   /note="AAA 2"
FT                   /evidence="ECO:0000250"
FT   REGION          2422..2669
FT                   /note="AAA 3"
FT                   /evidence="ECO:0000250"
FT   REGION          2767..3016
FT                   /note="AAA 4"
FT                   /evidence="ECO:0000250"
FT   REGION          3033..3325
FT                   /note="Stalk"
FT                   /evidence="ECO:0000250"
FT   REGION          3409..3636
FT                   /note="AAA 5"
FT                   /evidence="ECO:0000250"
FT   REGION          3846..4072
FT                   /note="AAA 6"
FT                   /evidence="ECO:0000250"
FT   COILED          482..502
FT                   /evidence="ECO:0000255"
FT   COILED          627..643
FT                   /evidence="ECO:0000255"
FT   COILED          734..805
FT                   /evidence="ECO:0000255"
FT   COILED          1036..1056
FT                   /evidence="ECO:0000255"
FT   COILED          1306..1337
FT                   /evidence="ECO:0000255"
FT   COILED          1443..1468
FT                   /evidence="ECO:0000255"
FT   COILED          3033..3134
FT                   /evidence="ECO:0000255"
FT   COILED          3263..3325
FT                   /evidence="ECO:0000255"
FT   COILED          3573..3642
FT                   /evidence="ECO:0000255"
FT   BINDING         154..161
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   BINDING         1852..1859
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   BINDING         2133..2140
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   BINDING         2460..2467
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   BINDING         2805..2812
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   4466 AA;  511783 MW;  C465CC5C6C6D325D CRC64;
     MGDVVDARLD FISEYILKSY KLKPDKWTKC INVEENKILM LEFLEKADNP QLVFTVNPAG
     LITPSYEFPS ALKNTKAIYF IKKGREPVGK DNIKTNLVYG DLSYTPLEQL SALVDEVLVP
     LLANPRNHEQ WPVVVSQDVL RHVHNLKSSV YVVAGQVKGK TLLPLPVGSE KVETAAGSEE
     KDDSYDRSLV HAIESVIIDW THQIRDVLKR DSAQPLLEGL NPGPMVEINF WKAKCENLDC
     IFQQLRDPKV RKMKELLERT QSSYLPSFNN IERDVEAALT EAQDINIHLK PLVYQIESMD
     ELEFSDLTPR LAPILHTVCL IWSNSDYYNT APRVIVLLQE ICNLLIDLCR TFLDPSEIFK
     LEPEESLEKV RGALTVLKNW RELYDEHRAK LKDYFKDGKE VKEWEFASPL VFTRMDNFIR
     RIETIQSLFE TNVEFSKLEK TEMGSMKGRM LSQQVEKIHE EFQECAKVFT ERPYDGLDPT
     CQEFLEDYEE FEKKVFDLDR RLGSILCQGF DDCCGLEAAF KMLDCYGPLL DRPVIRNDFE
     CKYPIVLMLY DQELDQSKEI YDEHMRVEEA NGNAPLNKNM PDVAGQLKWS AQLRDRISKP
     MGSLKHMEHP TGVRRILESE DAKVIFQKYE EMLNLLNKYE QKVFENWTKG VDEVCKTNLD
     QSLITRDDAS KLIMVNFDPK LVSVLREVKY LQIRGEETIP ESAASIYEKH ETLRKYVANL
     DLTVAWYNKV RKTVLEVEFP LIEGQLADLD TRLRQAEADL NWTSDSVWEY IQETRDQVRD
     LEKRVQQTKD NVDRIKKIMA EWTKQPLFER KELKKESLLA LDDRQDRLKK RYAEITTAGE
     KIHSLMKENL DLFKAEASSD IWKAYVDYVD DMVIDGFFNC IHCTLTYLLE NTDPRHCAAP
     LFEARLELQV PDMIFNPSLD YGIADGFYDL VEMLISDTYK MASLVNRLAE HNGQEHYQAD
     LEGMDDLSDV RNDLMDRVQT IMTKAQEYRN SFDNYAYLYV DDRKEFMRQF LLYNHVLTTE
     EIEAHAEDGV PECPPTLDQF KEQVDTYEKI YSEADEIEPE QVFDAWFRVD SKPFKAALLN
     IIKKWSFMFK QHLIDHVTNS LSELQEFIKV GNSGLTKTVE DGDYNGLVDC MGHLMAVKER
     QAATDEMFEP IKQTIELLKT YDQEMSEEVH TQLQELPEQW NNTKKIAITI KQQVAPLQAN
     EVAIIRRKCT SFDVRQHEFR ERFRKEAPFI FLFDGPYQCL DKCHSEIYEM EEHMAKLQES
     AGLFEVNMPD YKQLKACRRE VRLLKGLWDL IMVVRTSIED WKTTPWLEIN VEQMEMDCKK
     FAKDIRSLDK EMRAWDAYNG LDATVKNMLT SLRAVSELQN PAIRERHWQQ LMAATKVKFT
     MDKETTLSDL LALNLHNFED EVRNIVDKAV KEMGMEKVLK ELNTTWSSMD FDYEPHSRTG
     ISLLKSNEEL IETLEDNQVQ LQNLMTSKHI AHFLEEVSGW QKKLSTTDSV ITIWFEVQRT
     WSHLESIFIG SEDIRNQLPE DSKRFDGIDT DFKELAAEME KTPNVVEATN KARLFDRLEA
     IQGSLVVCEK ALAEYLETKR LAFPRFYFVS SADLLDILSQ GNNPTQVQRH LSKLFDNMAK
     LKFKQDDEGN DTKLALGMYS KEGEYVDFDK ECECTGQVEV WLNRVMDTMR STVRSQFADA
     VVSYEEKPRE QWLYDYPAQV ALATTQVWWT TEVNISFARL EEGHENSMKD YNKKQILQLN
     TLIGLLIGKL TKGDRQKIMT ICTIDVHARD VVAMMVLKKV DSAQAFQWLS QLRHRWADDD
     KHCYANICDA QFKYSYEYLG NTPRLVITPL TDRCYITLTQ SLHLVMSGAP AGPAGTGKTE
     TTKDLGRALG IMVYVFNCSE QMDYKSCGNI YKGLAQTGAW GCFDEFNRIS VEVLSVVAVQ
     VKCVQDAIRD KKERFNFMGE EISLIPSVGI FITMNPGYAG RTELPENLKA LFRPCAMVVP
     DFELICEIML VAEGFLEARL LARKFITLYT LCKELLSKQD HYDWGLRAIK SVLVVAGSLK
     RGDPQRPEDQ VLMRALRDFN VPKIVSDDTP VFMGLIGDLF PALDVPRRRD LDFEKVVKQS
     TLDLKLQAED SFVLKVVQLE ELLAVRHSVF VIGNAGTGKS QVLKVLNKTY SNMKRKPVFI
     DLNPKAVTND ELFGIINPAT REWKDGLFSV IMRDMSNITH DGPKWIVLDG DIDPMWIESL
     NTVMDDNKVL TLASNERIPL TPSMRLLFEI SHLKTATPAT VSRAGILYIN PSDLGWNPIV
     TSWIDTREVQ SERANLTILF DKYLPTLLDT LRIRFKKIIP IPEQSMVQML CYLLECLLTP
     ENTPADCPKE LYELYFVFAS IWAFGGSMFQ DQLVDYRVEF SKWWITEFKT IKFPNQGTVF
     DYYIDQESKK FLPWSEKVPT FELDPEIPMQ AVLVHTNETT RVRFFMDLLM ERGRPVMLVG
     NAGLGKSVLV GDKLSNLGED SMVANVPFNY YTTSEMLQRV LEKPLEKKAG RNYGPPGTKK
     LVYFIDDMNM PEVDTYGTVQ PHTLIRQHMD YKHWYDRAKL TLKEIHKCQY VSCMNPTSGS
     FTINSRLQRH FCVFALSFPG QDALSTIYNS ILSQHLANIA VSNALQKLSP TVVSATLDLH
     KKVAQSFLPT AIKFHYVFNL RDLSNVFQGL LYSGSDLLKS PIDFARLWMH ECQRVYGDKM
     INDQDIEAFE KLVFEYAKKF FEDVDEEALK AKPNIHCHFA TGIGDPKYMP CATWPELNKI
     LVEALDTYNE INAVMNLVLF EDAMQHVCRI NRILESPRGN ALLVGVGGSG KQSLARLASY
     ISSLEVFQIT LRKGYGIPDL KLDLATVCMK AGLKNIGTVF LMTDAQVSDE KFLVLINDLL
     ASGEIPDLFA DDEVENIIGG VRNEVKGMGL QDTRENCWKF FIDRLRRQLK TVLCFSPVGT
     TLRVRSRKFP AVVNCTSIDW FHEWPQEALV SVSKRFLDEV ELLKGDIKNS IAEFMAYVHV
     SVNESSKQYL TNERRYNYTT PKSFLEQIKL YESLLAMKSK ELTAKMERLE NGLTKLQSTA
     QQVDDLKAKL ASQEVELAQK NEDADKLIQV VGVETEKVSK EKATVDDEEK KVAIINEEVS
     KKAKDCSEDL AKAEPALLAA QEALNTLNKN NLTELKSFGS PPSAVLKVAA AVMVLLAPNG
     KIPKDRSWKA AKVVMNKVDA FLDSLINYDE ENIHENCQKA IKEYLNDPEF EPEYIKGKSL
     AAGGLCSWVV NIVKFYNVYC DVEPKRIALQ KANDELKAAQ DKLALIKAKI AELDANLAEL
     TAQFEKATSD KLKCQQEAEA TSRTITLANR LVGGLASENV RWGEAVANFK IQEKTLPGDV
     LLITAFVSYI GCFTKNYRVD LQDRMWLPFL KSQKDPIPIT EGLDVLSMLT DDADIAVWNN
     EGLPSDRMST ENATILSNCQ RWPLMIDPQL QGIKWIKQKY GDELRVIRIG QRGYLDTIEN
     AISSGDTVLI ENMEESIDPV LDPVLGRNTI KKGRYIKIGD KEVEYNPEFR LILQTKLANP
     HYKPEMQAQT TLINFTVTRD GLEDQLLANV VAQERPDLEK LKSDLTKQQN DFKIILKELE
     DNLLSRLSSA EGNFLGDTAL VENLETTKRT AAEISVKVEE AKVTEVKINE ARELYRPAAA
     RASLLYFILN DLNKINPIYQ FSLKAFNTVF SLSIARAEPC EDVKERVVNL IDCITYSVFI
     YTTRGLFEAD KLIFTTQVAF QVLLMKKEIA QNELDFLLRF PIQVGLTSPV DFLTNSAWGA
     IKSLSAMEDF RNLDRDIEGS AKRWKKFVES ECPEKEKFPQ EWKNKSALQK LCMMRALRAD
     RMSYAVRNFI EEKLGSKYVE GRQVEFAKSY EETDPATPVF FILSPGVDPL KDVEALGKKL
     GFTFDNNNFH NVSLGQGQEI VAEQCMDLAA KEGHWVILQN IHLVAKWLST LEKKLEQYSI
     GSHESYRVYM SAEPAGSPES HIIPQGILES SIKITNEPPT GMFANLHKAL YNFNQDTLEM
     CAREAEFKVI LFALCYFHAV VCERQKFGPQ GWNRSYPFNT GDLTISVNVL YNYLEANSKV
     PWQDLRYLFG EIMYGGHITD DWDRRLCRTY LEEYMAPEML DGDLYLAPGF PVPPNSDYKG
     YHQYIDEILP PESPYLYGLH PNAEIGFLTT ESDNLFKVVL ELQPRDAGGG GGGGSSREEK
     IKSLLDEIVE KLPEEFNMME IMGKVEDRTP YVVVAFQECE RMNTLTSEIR RSLKELDLGL
     KGELTITPDM EDLSNALFLD QIPASWVKRA YPSLFGLSAW YADLLQRIKE LEQWTADFAL
     PNVVWLGGFF NPQSFLTAIM QSMARKNEWP LDKMCLQCDV TKKNKEDFSS APREGSYVHG
     LFMEGARWDT QTNMIADARL KELAPNMPVI FIKAIPVDKQ DTRNIYECPV YKTKQRGPTF
     VWTFNLKSKE KAAKWTLAGV ALLLQV
 
 
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