ID   DYHC_ONCMY              Reviewed;         515 AA.
AC   P15305;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Dynein heavy chain;
DE            Short=DYHC;
DE   Flags: Fragment;
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RX   PubMed=2527745; DOI=10.1002/j.1460-2075.1989.tb03565.x;
RA   Garber A.T., Retief J.D., Dixon G.H.;
RT   "Isolation of dynein heavy chain cDNAs from trout testis which predict an
RT   extensive carboxyl-terminal alpha-helical coiled-coil domain.";
RL   EMBO J. 8:1727-1734(1989).
CC   -!- FUNCTION: Force generating protein of eukaryotic cilia and flagella.
CC       Produces force towards the minus ends of microtubules. Dynein has
CC       ATPase activity.
CC   -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC       intermediate and low mass polypeptides.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme.
CC       Cytoplasm, cytoskeleton, flagellum axoneme.
CC   -!- SIMILARITY: Belongs to the dynein heavy chain family. {ECO:0000305}.
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DR   EMBL; X15476; CAA33503.1; -; mRNA.
DR   PIR; S09598; S09598.
DR   AlphaFoldDB; P15305; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cytoplasm; Cytoskeleton; Dynein; Flagellum;
KW   Microtubule; Motor protein; Repeat.
FT   CHAIN           <1..515
FT                   /note="Dynein heavy chain"
FT                   /id="PRO_0000114651"
FT   REPEAT          4..11
FT   REPEAT          12..19
FT   REPEAT          20..27
FT   REPEAT          28..32
FT                   /note="Incomplete"
FT   REGION          35..508
FT                   /note="68 X 7 AA tandem repeats of [IL]-H-V-I-Q-Y-S"
FT   NON_TER         1
SQ   SEQUENCE   515 AA;  60923 MW;  79808A5C9623BBBA CRC64;
     PSMLFSTVPS TLFSTVPSTL FSTVPSTLFS TVSSVIQYSI HVIQYSTLHV IQYSTLHVIQ
     YSTLHVIQYS TLNVIQYSTL HVIQYSTLHV IQYSILHVIQ YSIHVIQYSI HVTQYSILHV
     IQYSIHVIQY SIHVIQYSTH VIQYSIHVIQ YSIHVIQYSI LHVIQYSIHV IQYSIHVIQY
     STHVIQYSIH VIQYSILHVI QYSILHVIQY SILHVIQYSI HVIQYSIHVI QYSIHVIQYS
     IHVIQYSILH VIQYSIHVIQ YSIHVIQYSI HVIQYSILHV IQYSILHVIQ YSIHVIQYSI
     HVIQYSIHVI QYSILHVIQY SIHVIQYSIH VIQYSIHVIQ YSIHVIQYSI HVIQYSILHV
     IQYSIHVIQY SIHVIQYSIH VIQYSIHVIQ YSILHVIQYS ILHVIQYSIH VIQYSILHVI
     QYSIHVIQYS IHVIQYSILH VIQYSIHVIQ YSILHVIQYS IHVIQYSIHV IQYSILHVIQ
     YSIHVIQYSI LHVIQYSIHV IQYSILHVMI LACSM