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DYI2_CHLRE
ID   DYI2_CHLRE              Reviewed;         683 AA.
AC   Q39578;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Dynein, 78 kDa intermediate chain, flagellar outer arm;
DE   AltName: Full=IC78;
GN   Name=ODA9; Synonyms=ODA-9;
OS   Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC   Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC   CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX   NCBI_TaxID=3055;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 2-18 AND 560-573.
RC   STRAIN=1132D;
RX   PubMed=7698982; DOI=10.1083/jcb.129.1.169;
RA   Wilkerson C.G., King S.M., Koutoulis A., Pazour G.J., Witman G.B.;
RT   "The 78,000 M(r) intermediate chain of Chlamydomonas outer arm dynein is a
RT   WD-repeat protein required for arm assembly.";
RL   J. Cell Biol. 129:169-178(1995).
CC   -!- FUNCTION: Is essential for arm assembly or attachment to the outer
CC       doublet microtubule.
CC   -!- SUBUNIT: Consists of at least 3 heavy chains (alpha, beta and gamma), 2
CC       intermediate chains and 8 light chains.
CC   -!- INTERACTION:
CC       Q39578; A8IPZ5: ODA3; NbExp=2; IntAct=EBI-8534634, EBI-8534794;
CC       Q39578; P27766: ODA6; NbExp=2; IntAct=EBI-8534634, EBI-6081316;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme.
CC   -!- SIMILARITY: Belongs to the dynein intermediate chain family.
CC       {ECO:0000305}.
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DR   EMBL; U19120; AAA80213.1; -; mRNA.
DR   PIR; A57037; A57037.
DR   PDB; 7KZM; EM; 7.50 A; D=1-683.
DR   PDB; 7KZN; EM; 4.00 A; D=1-683.
DR   PDBsum; 7KZM; -.
DR   PDBsum; 7KZN; -.
DR   AlphaFoldDB; Q39578; -.
DR   SMR; Q39578; -.
DR   IntAct; Q39578; 3.
DR   MINT; Q39578; -.
DR   STRING; 3055.EDP03447; -.
DR   eggNOG; KOG1587; Eukaryota.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell projection; Cilium; Cytoplasm; Cytoskeleton;
KW   Direct protein sequencing; Dynein; Flagellum; Microtubule; Motor protein;
KW   Repeat; WD repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:7698982"
FT   CHAIN           2..683
FT                   /note="Dynein, 78 kDa intermediate chain, flagellar outer
FT                   arm"
FT                   /id="PRO_0000114663"
FT   REPEAT          358..398
FT                   /note="WD 1"
FT   REPEAT          407..450
FT                   /note="WD 2"
FT   REPEAT          562..602
FT                   /note="WD 3"
FT   REPEAT          608..647
FT                   /note="WD 4"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   683 AA;  76525 MW;  13D4EE4EB9F461BD CRC64;
     MPALSPAKKG TDKGKTGKKT GKQEQNAQDY IPPPPPMPGD EAFAMPIREI VKPDNQLWLS
     EADLNEEVAK MLTANNPAAP KNIVRFNMKD KVFKLEPMVE QTVVHYATDG WLLHKSSDEA
     KRQMDMEKME QEASARFQAD IDRASHEHKD HGDVEPPDDS RQLRNQFNFS ERAAQTLNYP
     LRDRETFTEP PPTATVSGAC TQWEIYDEYI KDLERQRIDE AMKSKGGKKA AAAARAAGAA
     HRQRNEHVPT LQSPTLMHSL GTLDRMVNQN MYEEVAMDFK YWDDASDAFR PGEGSLLPLW
     RFVSDKSKRR QVTSVCWNPL YDDMFAVGYG SYEFLKQASG LINIYSLKNP SHPEYTFHTE
     SGVMCVHFHP EFANLLAVGC YDGSVLVYDV RLKKDEPIYQ ASVRTGKLND PVWQIYWQPD
     DAQKSLQFVS ISSDGAVNLW TLTKSELIPE CLMKLRVVRA GETREEEDPN ASGAAGGCCM
     DFCKMPGQES IYLVGTEEGA IHRCSKAYSS QYLSTYVSHH LAVYAVHWNN IHPSMFLSAS
     CRLDHQAVGL CHDPKRAVMN FDLNDSIGDV SWAALQPTVF AAVTDDGRVH VFDLAQNKLL
     PLCSQKVVKK AKLTKLVFNP KHPIVLVGDD KGCVTSLKLS PNLRITSKPE KGQKFEDLEV
     AKLDGVVEIA RKSDADLAKN AAH
 
 
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