DYI2_CHLRE
ID DYI2_CHLRE Reviewed; 683 AA.
AC Q39578;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Dynein, 78 kDa intermediate chain, flagellar outer arm;
DE AltName: Full=IC78;
GN Name=ODA9; Synonyms=ODA-9;
OS Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX NCBI_TaxID=3055;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 2-18 AND 560-573.
RC STRAIN=1132D;
RX PubMed=7698982; DOI=10.1083/jcb.129.1.169;
RA Wilkerson C.G., King S.M., Koutoulis A., Pazour G.J., Witman G.B.;
RT "The 78,000 M(r) intermediate chain of Chlamydomonas outer arm dynein is a
RT WD-repeat protein required for arm assembly.";
RL J. Cell Biol. 129:169-178(1995).
CC -!- FUNCTION: Is essential for arm assembly or attachment to the outer
CC doublet microtubule.
CC -!- SUBUNIT: Consists of at least 3 heavy chains (alpha, beta and gamma), 2
CC intermediate chains and 8 light chains.
CC -!- INTERACTION:
CC Q39578; A8IPZ5: ODA3; NbExp=2; IntAct=EBI-8534634, EBI-8534794;
CC Q39578; P27766: ODA6; NbExp=2; IntAct=EBI-8534634, EBI-6081316;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme.
CC -!- SIMILARITY: Belongs to the dynein intermediate chain family.
CC {ECO:0000305}.
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DR EMBL; U19120; AAA80213.1; -; mRNA.
DR PIR; A57037; A57037.
DR PDB; 7KZM; EM; 7.50 A; D=1-683.
DR PDB; 7KZN; EM; 4.00 A; D=1-683.
DR PDBsum; 7KZM; -.
DR PDBsum; 7KZN; -.
DR AlphaFoldDB; Q39578; -.
DR SMR; Q39578; -.
DR IntAct; Q39578; 3.
DR MINT; Q39578; -.
DR STRING; 3055.EDP03447; -.
DR eggNOG; KOG1587; Eukaryota.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell projection; Cilium; Cytoplasm; Cytoskeleton;
KW Direct protein sequencing; Dynein; Flagellum; Microtubule; Motor protein;
KW Repeat; WD repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:7698982"
FT CHAIN 2..683
FT /note="Dynein, 78 kDa intermediate chain, flagellar outer
FT arm"
FT /id="PRO_0000114663"
FT REPEAT 358..398
FT /note="WD 1"
FT REPEAT 407..450
FT /note="WD 2"
FT REPEAT 562..602
FT /note="WD 3"
FT REPEAT 608..647
FT /note="WD 4"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 683 AA; 76525 MW; 13D4EE4EB9F461BD CRC64;
MPALSPAKKG TDKGKTGKKT GKQEQNAQDY IPPPPPMPGD EAFAMPIREI VKPDNQLWLS
EADLNEEVAK MLTANNPAAP KNIVRFNMKD KVFKLEPMVE QTVVHYATDG WLLHKSSDEA
KRQMDMEKME QEASARFQAD IDRASHEHKD HGDVEPPDDS RQLRNQFNFS ERAAQTLNYP
LRDRETFTEP PPTATVSGAC TQWEIYDEYI KDLERQRIDE AMKSKGGKKA AAAARAAGAA
HRQRNEHVPT LQSPTLMHSL GTLDRMVNQN MYEEVAMDFK YWDDASDAFR PGEGSLLPLW
RFVSDKSKRR QVTSVCWNPL YDDMFAVGYG SYEFLKQASG LINIYSLKNP SHPEYTFHTE
SGVMCVHFHP EFANLLAVGC YDGSVLVYDV RLKKDEPIYQ ASVRTGKLND PVWQIYWQPD
DAQKSLQFVS ISSDGAVNLW TLTKSELIPE CLMKLRVVRA GETREEEDPN ASGAAGGCCM
DFCKMPGQES IYLVGTEEGA IHRCSKAYSS QYLSTYVSHH LAVYAVHWNN IHPSMFLSAS
CRLDHQAVGL CHDPKRAVMN FDLNDSIGDV SWAALQPTVF AAVTDDGRVH VFDLAQNKLL
PLCSQKVVKK AKLTKLVFNP KHPIVLVGDD KGCVTSLKLS PNLRITSKPE KGQKFEDLEV
AKLDGVVEIA RKSDADLAKN AAH