ID   DYI2_HELCR              Reviewed;         702 AA.
AC   Q16959;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Dynein intermediate chain 2, ciliary;
OS   Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Echinometridae;
OC   Heliocidaris.
OX   NCBI_TaxID=1043166;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Egg;
RX   PubMed=7579688; DOI=10.1091/mbc.6.6.685;
RA   Ogawa K., Kamiya R., Wilkerson C.G., Witman G.B.;
RT   "Interspecies conservation of outer arm dynein intermediate chain sequences
RT   defines two intermediate chain subclasses.";
RL   Mol. Biol. Cell 6:685-696(1995).
CC   -!- FUNCTION: Microtubule-binding protein that may be involved in dynein
CC       outer arm assembly on the axoneme. {ECO:0000250}.
CC   -!- SUBUNIT: Consists of at least two heavy chains (alpha and beta), three
CC       intermediate chains and several light chains.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dynein intermediate chain family.
CC       {ECO:0000305}.
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DR   EMBL; D38538; BAA07539.1; -; mRNA.
DR   AlphaFoldDB; Q16959; -.
DR   SMR; Q16959; -.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cytoplasm; Cytoskeleton; Dynein; Microtubule;
KW   Motor protein; Repeat; WD repeat.
FT   CHAIN           1..702
FT                   /note="Dynein intermediate chain 2, ciliary"
FT                   /id="PRO_0000114662"
FT   REPEAT          380..420
FT                   /note="WD 1"
FT   REPEAT          429..472
FT                   /note="WD 2"
FT   REPEAT          490..533
FT                   /note="WD 3"
FT   REPEAT          537..577
FT                   /note="WD 4"
FT   REPEAT          580..620
FT                   /note="WD 5"
FT   REPEAT          628..667
FT                   /note="WD 6"
FT   REGION          1..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          128..226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          243..272
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..24
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..52
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        148..182
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        184..226
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        243..270
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   702 AA;  79138 MW;  96931CFDAEFBAA8A CRC64;
     MPVKSTKTKG GSTQGGSQAG GPSTLKVNKA RVPAKGKKDD DDATEAGEHG GEEWMQTKSL
     IKPDDQLELN DQELKEEFTR ILTANNPHAP QNIVRYSFKD CSFKQTSHVD QLAIHFSLDG
     NMIHKDSDEA RRQQQRHGAS EAISEQAISE AGEEKKEEDG EQKTEEPKEG EKRDEESTPA
     PAEAKSDQKL TNQFNFSERA SQTYNNPYRE RGTQTEPPPR ANFSSTANQW EIYDAYMEDL
     EKQEKAKEKK AAPSKKDDDK SKKKLTALET QSDDMSRISH AAKIIERMVN QNTFDDVSQD
     FKYYEDMSDE FRDQEGTLLP LWKFSYDKSK RLAVTSVCWN PKYKDLFAVA HGSYDFMKQS
     RGMILFYTLK NPSFPEFVYP TDSGVMCIDI RPEHPYLICV GYCDGSVGVF NVTSTDANPV
     FQSTAKTGKH TDPVWQVAWQ KDDLDNNLNF FSVSSDGRVV AWTLVKNELT YTDVIQLQLD
     SAPQDGPEGT QLTPLGCGTC FDFHKQTDYL FLVGTEEGKI HKCSKAYSSQ FLDTFEAHHM
     AVYKVMWNHF HPKIFISCSA DWSVKIWDHT YRNGPMFTFD LGSAVGDVAW APYSSTVFAA
     VTADGKVHVF DLNLNKYEPI CEQAVVQKKK TKLTHITFNP NFPIVLVGDD RGYVSSLKLS
     PNLRKVPKDK KGAALNHGPE AEIAKMDKLL ALVREPPKDN KS