DYI3_CHLRE
ID DYI3_CHLRE Reviewed; 567 AA.
AC P27766;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1992, sequence version 1.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=Dynein, 70 kDa intermediate chain, flagellar outer arm;
DE AltName: Full=IC69;
DE AltName: Full=IC70;
GN Name=ODA6; Synonyms=IC70, ODA-6;
OS Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX NCBI_TaxID=3055;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 332-350.
RC STRAIN=137c / CC-125;
RX PubMed=1673970; DOI=10.1083/jcb.113.4.835;
RA Mitchell D.R., Kang Y.;
RT "Identification of oda6 as a Chlamydomonas dynein mutant by rescue with the
RT wild-type gene.";
RL J. Cell Biol. 113:835-842(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=137c / CC-125;
RX PubMed=8227195; DOI=10.1242/jcs.105.4.1069;
RA Mitchell D.R., Kang Y.;
RT "Reversion analysis of dynein intermediate chain function.";
RL J. Cell Sci. 105:1069-1078(1993).
CC -!- FUNCTION: May play a role in regulating dynein heavy chain (DHC)
CC activity. May function in holding IC78 to the DHC, or in stabilizing
CC the entire dynein complex.
CC -!- SUBUNIT: Consists of at least 3 heavy chains (alpha, beta and gamma), 2
CC intermediate chains and 8 light chains.
CC -!- INTERACTION:
CC P27766; A8IPZ5: ODA3; NbExp=3; IntAct=EBI-6081316, EBI-8534794;
CC P27766; Q39578: ODA9; NbExp=2; IntAct=EBI-6081316, EBI-8534634;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme.
CC -!- SIMILARITY: Belongs to the dynein intermediate chain family.
CC {ECO:0000305}.
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DR EMBL; X55382; CAA39053.1; -; mRNA.
DR EMBL; X68128; CAA48233.1; -; Genomic_DNA.
DR PIR; S25521; S25521.
DR PDB; 7KZM; EM; 7.50 A; E=1-567.
DR PDB; 7KZN; EM; 4.00 A; E=1-567.
DR PDBsum; 7KZM; -.
DR PDBsum; 7KZN; -.
DR AlphaFoldDB; P27766; -.
DR SMR; P27766; -.
DR IntAct; P27766; 6.
DR MINT; P27766; -.
DR STRING; 3055.EDP05451; -.
DR eggNOG; KOG1587; Eukaryota.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IDA:BHF-UCL.
DR GO; GO:0060294; P:cilium movement involved in cell motility; IMP:GO_Central.
DR GO; GO:0036158; P:outer dynein arm assembly; IMP:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell projection; Cilium; Cytoplasm; Cytoskeleton;
KW Direct protein sequencing; Dynein; Flagellum; Microtubule; Motor protein;
KW Repeat; WD repeat.
FT CHAIN 1..567
FT /note="Dynein, 70 kDa intermediate chain, flagellar outer
FT arm"
FT /id="PRO_0000114665"
FT REPEAT 214..254
FT /note="WD 1"
FT REPEAT 261..302
FT /note="WD 2"
FT REPEAT 360..399
FT /note="WD 3"
FT REPEAT 404..444
FT /note="WD 4"
SQ SEQUENCE 567 AA; 63520 MW; F32D2BD11200665D CRC64;
MEIYHQYIKL RKQFGRFPKF GDEGSEMLAD IRPNEDHGKE YIPRNPVTTV TQCVPEMSEH
EANTNAVILV NKAMSHVEGG WPKDVDYTEA EHTIRYRKKV EKDEDYIRTV VQLGSSVEDL
IKQNNAVDIY QEYFTNVTMD HTSEAPHVKT VTVFKDPNNI KRSASYVNWH PDGSVPKVVV
AYSILQFQQQ PAGMPLSSYI WDVNNPNTPE YEMVPTSQIC CAKFNLKDNN LVGAGQYNGQ
LAYFDVRKGN GPVEATPIDI SHRDPIYDFA WLQSKTGTEC MTVSTDGNVL WWDLRKMNEC
VENMPLKEKN SETTVGGVCL EYDTNAGPTN FMVGTEQGQI FSCNRKAKNP VDRVKYVLSG
HHGPIYGLRR NPFNSKYFLS IGDWTARVWV EDTAVKTPIL TTKYHPTYLT GGTWSPSRPG
VFFTIKMDGA MDVWDLYYKH NEPTLTVQVS DLALTAFAVQ ESGGTVAVGT SDGCTSVLQL
STGLSEASPA EKANINAMFE RETTREKNLE KAIKEAKVKA RKEQGRRDEV KDNVTEEQLK
ALEDEFFKTT DPAVGGGYGA GEGAAAE