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DYI3_CHLRE
ID   DYI3_CHLRE              Reviewed;         567 AA.
AC   P27766;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Dynein, 70 kDa intermediate chain, flagellar outer arm;
DE   AltName: Full=IC69;
DE   AltName: Full=IC70;
GN   Name=ODA6; Synonyms=IC70, ODA-6;
OS   Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC   Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC   CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX   NCBI_TaxID=3055;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 332-350.
RC   STRAIN=137c / CC-125;
RX   PubMed=1673970; DOI=10.1083/jcb.113.4.835;
RA   Mitchell D.R., Kang Y.;
RT   "Identification of oda6 as a Chlamydomonas dynein mutant by rescue with the
RT   wild-type gene.";
RL   J. Cell Biol. 113:835-842(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=137c / CC-125;
RX   PubMed=8227195; DOI=10.1242/jcs.105.4.1069;
RA   Mitchell D.R., Kang Y.;
RT   "Reversion analysis of dynein intermediate chain function.";
RL   J. Cell Sci. 105:1069-1078(1993).
CC   -!- FUNCTION: May play a role in regulating dynein heavy chain (DHC)
CC       activity. May function in holding IC78 to the DHC, or in stabilizing
CC       the entire dynein complex.
CC   -!- SUBUNIT: Consists of at least 3 heavy chains (alpha, beta and gamma), 2
CC       intermediate chains and 8 light chains.
CC   -!- INTERACTION:
CC       P27766; A8IPZ5: ODA3; NbExp=3; IntAct=EBI-6081316, EBI-8534794;
CC       P27766; Q39578: ODA9; NbExp=2; IntAct=EBI-6081316, EBI-8534634;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme.
CC   -!- SIMILARITY: Belongs to the dynein intermediate chain family.
CC       {ECO:0000305}.
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DR   EMBL; X55382; CAA39053.1; -; mRNA.
DR   EMBL; X68128; CAA48233.1; -; Genomic_DNA.
DR   PIR; S25521; S25521.
DR   PDB; 7KZM; EM; 7.50 A; E=1-567.
DR   PDB; 7KZN; EM; 4.00 A; E=1-567.
DR   PDBsum; 7KZM; -.
DR   PDBsum; 7KZN; -.
DR   AlphaFoldDB; P27766; -.
DR   SMR; P27766; -.
DR   IntAct; P27766; 6.
DR   MINT; P27766; -.
DR   STRING; 3055.EDP05451; -.
DR   eggNOG; KOG1587; Eukaryota.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0031514; C:motile cilium; IDA:BHF-UCL.
DR   GO; GO:0060294; P:cilium movement involved in cell motility; IMP:GO_Central.
DR   GO; GO:0036158; P:outer dynein arm assembly; IMP:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell projection; Cilium; Cytoplasm; Cytoskeleton;
KW   Direct protein sequencing; Dynein; Flagellum; Microtubule; Motor protein;
KW   Repeat; WD repeat.
FT   CHAIN           1..567
FT                   /note="Dynein, 70 kDa intermediate chain, flagellar outer
FT                   arm"
FT                   /id="PRO_0000114665"
FT   REPEAT          214..254
FT                   /note="WD 1"
FT   REPEAT          261..302
FT                   /note="WD 2"
FT   REPEAT          360..399
FT                   /note="WD 3"
FT   REPEAT          404..444
FT                   /note="WD 4"
SQ   SEQUENCE   567 AA;  63520 MW;  F32D2BD11200665D CRC64;
     MEIYHQYIKL RKQFGRFPKF GDEGSEMLAD IRPNEDHGKE YIPRNPVTTV TQCVPEMSEH
     EANTNAVILV NKAMSHVEGG WPKDVDYTEA EHTIRYRKKV EKDEDYIRTV VQLGSSVEDL
     IKQNNAVDIY QEYFTNVTMD HTSEAPHVKT VTVFKDPNNI KRSASYVNWH PDGSVPKVVV
     AYSILQFQQQ PAGMPLSSYI WDVNNPNTPE YEMVPTSQIC CAKFNLKDNN LVGAGQYNGQ
     LAYFDVRKGN GPVEATPIDI SHRDPIYDFA WLQSKTGTEC MTVSTDGNVL WWDLRKMNEC
     VENMPLKEKN SETTVGGVCL EYDTNAGPTN FMVGTEQGQI FSCNRKAKNP VDRVKYVLSG
     HHGPIYGLRR NPFNSKYFLS IGDWTARVWV EDTAVKTPIL TTKYHPTYLT GGTWSPSRPG
     VFFTIKMDGA MDVWDLYYKH NEPTLTVQVS DLALTAFAVQ ESGGTVAVGT SDGCTSVLQL
     STGLSEASPA EKANINAMFE RETTREKNLE KAIKEAKVKA RKEQGRRDEV KDNVTEEQLK
     ALEDEFFKTT DPAVGGGYGA GEGAAAE
 
 
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