DYI3_HELCR
ID DYI3_HELCR Reviewed; 597 AA.
AC Q16960;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Dynein intermediate chain 3, ciliary;
OS Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC Euechinoidea; Echinacea; Camarodonta; Echinidea; Echinometridae;
OC Heliocidaris.
OX NCBI_TaxID=1043166;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Egg;
RX PubMed=7579688; DOI=10.1091/mbc.6.6.685;
RA Ogawa K., Kamiya R., Wilkerson C.G., Witman G.B.;
RT "Interspecies conservation of outer arm dynein intermediate chain sequences
RT defines two intermediate chain subclasses.";
RL Mol. Biol. Cell 6:685-696(1995).
CC -!- FUNCTION: May play a role in the regulation of dynein heavy chain
CC activity.
CC -!- SUBUNIT: Consists of at least two heavy chains (alpha and beta), three
CC intermediate chains and several light chains.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme.
CC -!- SIMILARITY: Belongs to the dynein intermediate chain family.
CC {ECO:0000305}.
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DR EMBL; D28863; BAA06013.1; -; mRNA.
DR AlphaFoldDB; Q16960; -.
DR SMR; Q16960; -.
DR PRIDE; Q16960; -.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Cytoplasm; Cytoskeleton; Dynein; Microtubule;
KW Motor protein; Repeat; WD repeat.
FT CHAIN 1..597
FT /note="Dynein intermediate chain 3, ciliary"
FT /id="PRO_0000114664"
FT REPEAT 159..210
FT /note="WD 1"
FT REPEAT 213..253
FT /note="WD 2"
FT REPEAT 260..301
FT /note="WD 3"
FT REPEAT 314..354
FT /note="WD 4"
FT REPEAT 361..400
FT /note="WD 5"
FT REPEAT 404..444
FT /note="WD 6"
FT REPEAT 449..488
FT /note="WD 7"
FT REGION 512..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 562..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 512..527
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..544
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..597
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 597 AA; 68225 MW; 71A2B57878636084 CRC64;
MEIVYVYTKK RSEFGRQCNF SDRPAELHVD ILPDESLLSN FIEKNPVDRG IQCVQEMSEH
EINTERFETD SRGINHMEGG WPKDINPQEV EQVLRFRKKV EKDESYVTTI QNLASSMEHT
IKQNNAIDIY EDYFADLEIE EVEETPSAKT INVFRDPNEI KRPATHLSWY PDGPKKLAVA
YSSLEFQKTS AETSMDSYIW DIENPNKPEF VLKPVSPLVC LEYNPKDVHV LIGGCYNGQV
AFWDTRKGSQ AVEMSPVEHS HHDPVYKTIW LQSKTGTECF SASTDGQVLW WDMRKLGEPT
EKLIMDPSKK GKMENAQGVI SLEYEPTIPT KFMVGTEQGT IISCNRKAKT PPEKIVAIYK
EHIGPVYSLQ RNPFFPKNFL TVGDWTARIW SEDIRDSSIM WTKYHMSYLT DGCWSPVRPA
VFFTTKMDGS LDVWDYLFKQ KDPTLSLQVS DDALHSLRVQ DQGRLIATGS NSGTTTLLEL
SSGLCTMQRN EKALVTAMFE RETKREKILE SRQRELRLKR QGASAQGQDD DEEGGPDEEE
DLVAAAEKEF FQIVQADKKK FAAQQAKLSE QDNKIIEEAE ENNGSEKKDT ENGEKEG