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DYI3_HELCR
ID   DYI3_HELCR              Reviewed;         597 AA.
AC   Q16960;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Dynein intermediate chain 3, ciliary;
OS   Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Echinometridae;
OC   Heliocidaris.
OX   NCBI_TaxID=1043166;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Egg;
RX   PubMed=7579688; DOI=10.1091/mbc.6.6.685;
RA   Ogawa K., Kamiya R., Wilkerson C.G., Witman G.B.;
RT   "Interspecies conservation of outer arm dynein intermediate chain sequences
RT   defines two intermediate chain subclasses.";
RL   Mol. Biol. Cell 6:685-696(1995).
CC   -!- FUNCTION: May play a role in the regulation of dynein heavy chain
CC       activity.
CC   -!- SUBUNIT: Consists of at least two heavy chains (alpha and beta), three
CC       intermediate chains and several light chains.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme.
CC   -!- SIMILARITY: Belongs to the dynein intermediate chain family.
CC       {ECO:0000305}.
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DR   EMBL; D28863; BAA06013.1; -; mRNA.
DR   AlphaFoldDB; Q16960; -.
DR   SMR; Q16960; -.
DR   PRIDE; Q16960; -.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cytoplasm; Cytoskeleton; Dynein; Microtubule;
KW   Motor protein; Repeat; WD repeat.
FT   CHAIN           1..597
FT                   /note="Dynein intermediate chain 3, ciliary"
FT                   /id="PRO_0000114664"
FT   REPEAT          159..210
FT                   /note="WD 1"
FT   REPEAT          213..253
FT                   /note="WD 2"
FT   REPEAT          260..301
FT                   /note="WD 3"
FT   REPEAT          314..354
FT                   /note="WD 4"
FT   REPEAT          361..400
FT                   /note="WD 5"
FT   REPEAT          404..444
FT                   /note="WD 6"
FT   REPEAT          449..488
FT                   /note="WD 7"
FT   REGION          512..546
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          562..597
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        512..527
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        530..544
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        571..597
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   597 AA;  68225 MW;  71A2B57878636084 CRC64;
     MEIVYVYTKK RSEFGRQCNF SDRPAELHVD ILPDESLLSN FIEKNPVDRG IQCVQEMSEH
     EINTERFETD SRGINHMEGG WPKDINPQEV EQVLRFRKKV EKDESYVTTI QNLASSMEHT
     IKQNNAIDIY EDYFADLEIE EVEETPSAKT INVFRDPNEI KRPATHLSWY PDGPKKLAVA
     YSSLEFQKTS AETSMDSYIW DIENPNKPEF VLKPVSPLVC LEYNPKDVHV LIGGCYNGQV
     AFWDTRKGSQ AVEMSPVEHS HHDPVYKTIW LQSKTGTECF SASTDGQVLW WDMRKLGEPT
     EKLIMDPSKK GKMENAQGVI SLEYEPTIPT KFMVGTEQGT IISCNRKAKT PPEKIVAIYK
     EHIGPVYSLQ RNPFFPKNFL TVGDWTARIW SEDIRDSSIM WTKYHMSYLT DGCWSPVRPA
     VFFTTKMDGS LDVWDYLFKQ KDPTLSLQVS DDALHSLRVQ DQGRLIATGS NSGTTTLLEL
     SSGLCTMQRN EKALVTAMFE RETKREKILE SRQRELRLKR QGASAQGQDD DEEGGPDEEE
     DLVAAAEKEF FQIVQADKKK FAAQQAKLSE QDNKIIEEAE ENNGSEKKDT ENGEKEG
 
 
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