DYIN_DICDI
ID DYIN_DICDI Reviewed; 654 AA.
AC P54703; Q54UP8;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 25-MAY-2022, entry version 126.
DE RecName: Full=Cytoplasmic dynein 1 intermediate chain;
DE Short=DH IC;
DE AltName: Full=Dynein intermediate chain, cytosolic;
GN Name=dicA; ORFNames=DDB_G0280849;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=AX3;
RA Trivinos-Lagos L., Collins C.A., Chisholm R.L.;
RL Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Acts as one of several non-catalytic accessory components of
CC the cytoplasmic dynein 1 complex that are thought to be involved in
CC linking dynein to cargos and to adapter proteins that regulate dynein
CC function. Cytoplasmic dynein 1 acts as a motor for the intracellular
CC retrograde motility of vesicles and organelles along microtubules. The
CC intermediate chain mediates the binding of dynein to dynactin.
CC -!- SUBUNIT: Homodimer. The cytoplasmic dynein 1 complex consists of two
CC catalytic heavy chains (HCs) and a number of non-catalytic subunits
CC presented by intermediate chains (ICs), light intermediate chains
CC (LICs) and light chains (LCs). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the dynein intermediate chain family.
CC {ECO:0000305}.
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DR EMBL; U25116; AAA65986.1; -; mRNA.
DR EMBL; AAFI02000039; EAL66966.1; -; Genomic_DNA.
DR RefSeq; XP_640973.1; XM_635881.1.
DR AlphaFoldDB; P54703; -.
DR SMR; P54703; -.
DR STRING; 44689.DDB0215397; -.
DR PaxDb; P54703; -.
DR EnsemblProtists; EAL66966; EAL66966; DDB_G0280849.
DR GeneID; 8622777; -.
DR KEGG; ddi:DDB_G0280849; -.
DR dictyBase; DDB_G0280849; dicA.
DR eggNOG; KOG1587; Eukaryota.
DR HOGENOM; CLU_012999_2_0_1; -.
DR InParanoid; P54703; -.
DR OMA; EEGSIYP; -.
DR PhylomeDB; P54703; -.
DR Reactome; R-DDI-6807878; COPI-mediated anterograde transport.
DR PRO; PR:P54703; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005813; C:centrosome; TAS:dictyBase.
DR GO; GO:0005868; C:cytoplasmic dynein complex; IDA:dictyBase.
DR GO; GO:0036186; C:early phagosome membrane; IC:dictyBase.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0061474; C:phagolysosome membrane; IC:dictyBase.
DR GO; GO:0034452; F:dynactin binding; IMP:dictyBase.
DR GO; GO:0045504; F:dynein heavy chain binding; IMP:dictyBase.
DR GO; GO:0045503; F:dynein light chain binding; IBA:GO_Central.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IC:dictyBase.
DR GO; GO:0051298; P:centrosome duplication; IMP:dictyBase.
DR GO; GO:0051299; P:centrosome separation; IMP:dictyBase.
DR GO; GO:0051645; P:Golgi localization; IMP:dictyBase.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IMP:dictyBase.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR GO; GO:0072382; P:minus-end-directed vesicle transport along microtubule; IDA:dictyBase.
DR GO; GO:0010970; P:transport along microtubule; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR025956; DYNC1I1/DYNC1I2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF11540; Dynein_IC2; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Cytoskeleton; Dynein; Microtubule; Motor protein;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..654
FT /note="Cytoplasmic dynein 1 intermediate chain"
FT /id="PRO_0000114660"
FT REPEAT 277..326
FT /note="WD 1"
FT REPEAT 330..370
FT /note="WD 2"
FT REPEAT 378..419
FT /note="WD 3"
FT REPEAT 445..485
FT /note="WD 4"
FT REPEAT 490..535
FT /note="WD 5"
FT REPEAT 538..578
FT /note="WD 6"
FT REPEAT 583..622
FT /note="WD 7"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 71..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 116..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1..35
FT /evidence="ECO:0000255"
FT COMPBIAS 1..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 23
FT /note="E -> G (in Ref. 1; AAA65986)"
FT /evidence="ECO:0000305"
FT CONFLICT 155
FT /note="Missing (in Ref. 1; AAA65986)"
FT /evidence="ECO:0000305"
FT CONFLICT 222
FT /note="D -> S (in Ref. 1; AAA65986)"
FT /evidence="ECO:0000305"
FT CONFLICT 490..492
FT /note="GHF -> EL (in Ref. 1; AAA65986)"
FT /evidence="ECO:0000305"
FT CONFLICT 576
FT /note="A -> G (in Ref. 1; AAA65986)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 654 AA; 72328 MW; 702CF552C4B0E9E9 CRC64;
MDRDQKKKEL EQTKNEMRRK LEEYKERNRI MASKTTPTAT TTSTLNTAST PSPPVAQEDF
NSIMNSIDSM VPTQATPSSS STISTSTHAE SQKSNYIRPT LTIQSLVIEH DFPPKEIPMY
SKGTQTMTDA DTSNTNNTPE LEAPNKNKTK YQLLQQQQQQ QQQQQSSLNQ DMQNLSIGTD
SINGDGSSTS VANSANIDDD DKDEIEIPEL DENEKKDILE SDSFKSFFGR SSRVIERALC
LDDSIDILVD YTISDENSKG TSKELKLLAT LSDERWTKHR SITDISWSTK HPELVVSSYS
ANEAGSHDPD GVALVWSVNN YFQKPEYVFT CQSPVMTTFF SKFHSTLIVG GTYSGQIVIW
DTRAEAKPVQ KTPLSSVGHT HPVYSMAVVG SANANSLVSI STDAKLCSWN LENLSQPIET
IELNSSNTNS ANKAGGGGSG GGAPNMSIAV TSLVFPENEL NHFYIGTEEG VICQAGRHGN
RIVMNERYKG HFGPITSVDL HPSKGGADFS QYFLSSSTDW TCKLWSSKKE TPLYSFEDYV
DYVYDARWSP VHPSIFSTGD GSGTLSLWDL NQDLEAPIFR HKISNRSVNR LAWSHDGKRI
LVGDSGGSLS LFDSSEFSSP TSEEYSQFED VMTKMVNKSR TSDSPLLGEG ENQE