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DYIN_DICDI
ID   DYIN_DICDI              Reviewed;         654 AA.
AC   P54703; Q54UP8;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   25-MAY-2022, entry version 126.
DE   RecName: Full=Cytoplasmic dynein 1 intermediate chain;
DE            Short=DH IC;
DE   AltName: Full=Dynein intermediate chain, cytosolic;
GN   Name=dicA; ORFNames=DDB_G0280849;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=AX3;
RA   Trivinos-Lagos L., Collins C.A., Chisholm R.L.;
RL   Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Acts as one of several non-catalytic accessory components of
CC       the cytoplasmic dynein 1 complex that are thought to be involved in
CC       linking dynein to cargos and to adapter proteins that regulate dynein
CC       function. Cytoplasmic dynein 1 acts as a motor for the intracellular
CC       retrograde motility of vesicles and organelles along microtubules. The
CC       intermediate chain mediates the binding of dynein to dynactin.
CC   -!- SUBUNIT: Homodimer. The cytoplasmic dynein 1 complex consists of two
CC       catalytic heavy chains (HCs) and a number of non-catalytic subunits
CC       presented by intermediate chains (ICs), light intermediate chains
CC       (LICs) and light chains (LCs). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dynein intermediate chain family.
CC       {ECO:0000305}.
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DR   EMBL; U25116; AAA65986.1; -; mRNA.
DR   EMBL; AAFI02000039; EAL66966.1; -; Genomic_DNA.
DR   RefSeq; XP_640973.1; XM_635881.1.
DR   AlphaFoldDB; P54703; -.
DR   SMR; P54703; -.
DR   STRING; 44689.DDB0215397; -.
DR   PaxDb; P54703; -.
DR   EnsemblProtists; EAL66966; EAL66966; DDB_G0280849.
DR   GeneID; 8622777; -.
DR   KEGG; ddi:DDB_G0280849; -.
DR   dictyBase; DDB_G0280849; dicA.
DR   eggNOG; KOG1587; Eukaryota.
DR   HOGENOM; CLU_012999_2_0_1; -.
DR   InParanoid; P54703; -.
DR   OMA; EEGSIYP; -.
DR   PhylomeDB; P54703; -.
DR   Reactome; R-DDI-6807878; COPI-mediated anterograde transport.
DR   PRO; PR:P54703; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005813; C:centrosome; TAS:dictyBase.
DR   GO; GO:0005868; C:cytoplasmic dynein complex; IDA:dictyBase.
DR   GO; GO:0036186; C:early phagosome membrane; IC:dictyBase.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0061474; C:phagolysosome membrane; IC:dictyBase.
DR   GO; GO:0034452; F:dynactin binding; IMP:dictyBase.
DR   GO; GO:0045504; F:dynein heavy chain binding; IMP:dictyBase.
DR   GO; GO:0045503; F:dynein light chain binding; IBA:GO_Central.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IC:dictyBase.
DR   GO; GO:0051298; P:centrosome duplication; IMP:dictyBase.
DR   GO; GO:0051299; P:centrosome separation; IMP:dictyBase.
DR   GO; GO:0051645; P:Golgi localization; IMP:dictyBase.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IMP:dictyBase.
DR   GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR   GO; GO:0072382; P:minus-end-directed vesicle transport along microtubule; IDA:dictyBase.
DR   GO; GO:0010970; P:transport along microtubule; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR025956; DYNC1I1/DYNC1I2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF11540; Dynein_IC2; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Dynein; Microtubule; Motor protein;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..654
FT                   /note="Cytoplasmic dynein 1 intermediate chain"
FT                   /id="PRO_0000114660"
FT   REPEAT          277..326
FT                   /note="WD 1"
FT   REPEAT          330..370
FT                   /note="WD 2"
FT   REPEAT          378..419
FT                   /note="WD 3"
FT   REPEAT          445..485
FT                   /note="WD 4"
FT   REPEAT          490..535
FT                   /note="WD 5"
FT   REPEAT          538..578
FT                   /note="WD 6"
FT   REPEAT          583..622
FT                   /note="WD 7"
FT   REGION          1..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          71..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          116..144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          175..205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1..35
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..30
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..59
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        121..144
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        175..195
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        23
FT                   /note="E -> G (in Ref. 1; AAA65986)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        155
FT                   /note="Missing (in Ref. 1; AAA65986)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        222
FT                   /note="D -> S (in Ref. 1; AAA65986)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        490..492
FT                   /note="GHF -> EL (in Ref. 1; AAA65986)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        576
FT                   /note="A -> G (in Ref. 1; AAA65986)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   654 AA;  72328 MW;  702CF552C4B0E9E9 CRC64;
     MDRDQKKKEL EQTKNEMRRK LEEYKERNRI MASKTTPTAT TTSTLNTAST PSPPVAQEDF
     NSIMNSIDSM VPTQATPSSS STISTSTHAE SQKSNYIRPT LTIQSLVIEH DFPPKEIPMY
     SKGTQTMTDA DTSNTNNTPE LEAPNKNKTK YQLLQQQQQQ QQQQQSSLNQ DMQNLSIGTD
     SINGDGSSTS VANSANIDDD DKDEIEIPEL DENEKKDILE SDSFKSFFGR SSRVIERALC
     LDDSIDILVD YTISDENSKG TSKELKLLAT LSDERWTKHR SITDISWSTK HPELVVSSYS
     ANEAGSHDPD GVALVWSVNN YFQKPEYVFT CQSPVMTTFF SKFHSTLIVG GTYSGQIVIW
     DTRAEAKPVQ KTPLSSVGHT HPVYSMAVVG SANANSLVSI STDAKLCSWN LENLSQPIET
     IELNSSNTNS ANKAGGGGSG GGAPNMSIAV TSLVFPENEL NHFYIGTEEG VICQAGRHGN
     RIVMNERYKG HFGPITSVDL HPSKGGADFS QYFLSSSTDW TCKLWSSKKE TPLYSFEDYV
     DYVYDARWSP VHPSIFSTGD GSGTLSLWDL NQDLEAPIFR HKISNRSVNR LAWSHDGKRI
     LVGDSGGSLS LFDSSEFSSP TSEEYSQFED VMTKMVNKSR TSDSPLLGEG ENQE
 
 
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