DYL1_ASHGO
ID DYL1_ASHGO Reviewed; 88 AA.
AC Q759T0;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Dynein light chain 1, cytoplasmic;
GN Name=DYN2; OrderedLocusNames=ADR193W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Acts as one of several non-catalytic accessory components of
CC the cytoplasmic dynein complex that are thought to be involved in
CC linking dynein to cargos and to adapter proteins that regulate dynein
CC function. Cytoplasmic dynein 1 acts as a motor for the intracellular
CC retrograde motility of vesicles and organelles along microtubules. May
CC play a role in changing or maintaining the spatial distribution of
CC cytoskeletal structures (By similarity). Also a component of the
CC nuclear pore complex (By similarity). {ECO:0000250,
CC ECO:0000250|UniProtKB:Q02647}.
CC -!- SUBUNIT: Homodimer. Cytoplasmic dynein consists of two catalytic heavy
CC chains (HCs) and a number of non-catalytic subunits which present
CC intermediate chains (ICs), light intermediate chains (LICs) and light
CC chains (LCs). Component of the nuclear pore complex (NPC). NPC
CC constitutes the exclusive means of nucleocytoplasmic transport. NPCs
CC allow the passive diffusion of ions and small molecules and the active,
CC nuclear transport receptor-mediated bidirectional transport of
CC macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and
CC ribosomal subunits across the nuclear envelope. Due to its 8-fold
CC rotational symmetry, all subunits are present with 8 copies or
CC multiples thereof. {ECO:0000250|UniProtKB:Q02647}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:Q02647}. Nucleus, nuclear pore complex
CC {ECO:0000250|UniProtKB:Q02647}.
CC -!- SIMILARITY: Belongs to the dynein light chain family. {ECO:0000305}.
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DR EMBL; AE016817; AAS52113.1; -; Genomic_DNA.
DR RefSeq; NP_984289.1; NM_209642.1.
DR AlphaFoldDB; Q759T0; -.
DR SMR; Q759T0; -.
DR STRING; 33169.AAS52113; -.
DR PRIDE; Q759T0; -.
DR EnsemblFungi; AAS52113; AAS52113; AGOS_ADR193W.
DR GeneID; 4620451; -.
DR KEGG; ago:AGOS_ADR193W; -.
DR eggNOG; KOG3430; Eukaryota.
DR HOGENOM; CLU_070944_4_0_1; -.
DR InParanoid; Q759T0; -.
DR OMA; RHGATWH; -.
DR Proteomes; UP000000591; Chromosome IV.
DR GO; GO:0005868; C:cytoplasmic dynein complex; IBA:GO_Central.
DR GO; GO:0005881; C:cytoplasmic microtubule; IEA:EnsemblFungi.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR GO; GO:1990429; C:peroxisomal importomer complex; IEA:EnsemblFungi.
DR GO; GO:0005777; C:peroxisome; IEA:EnsemblFungi.
DR GO; GO:0045505; F:dynein intermediate chain binding; IBA:GO_Central.
DR GO; GO:0008574; F:plus-end-directed microtubule motor activity; IEA:EnsemblFungi.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:EnsemblFungi.
DR GO; GO:0040001; P:establishment of mitotic spindle localization; IEA:EnsemblFungi.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0030473; P:nuclear migration along microtubule; IEA:EnsemblFungi.
DR GO; GO:0051292; P:nuclear pore complex assembly; IEA:EnsemblFungi.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 3.30.740.10; -; 1.
DR InterPro; IPR037177; DLC_sf.
DR InterPro; IPR019763; Dynein_light_1/2_CS.
DR InterPro; IPR001372; Dynein_light_chain_typ-1/2.
DR PANTHER; PTHR11886; PTHR11886; 1.
DR Pfam; PF01221; Dynein_light; 1.
DR SMART; SM01375; Dynein_light; 1.
DR SUPFAM; SSF54648; SSF54648; 1.
DR PROSITE; PS01239; DYNEIN_LIGHT_1; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Cytoskeleton; Dynein; Microtubule; Motor protein;
KW mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW Reference proteome; Translocation; Transport.
FT CHAIN 1..88
FT /note="Dynein light chain 1, cytoplasmic"
FT /id="PRO_0000195143"
SQ SEQUENCE 88 AA; 10048 MW; EC0D7A4ACBF373C7 CRC64;
MSKPAILKAS DITDELRDEI FGISVQAVEQ FQLEREVAAY IKKELDSKHG QTWHVIVGKN
FGSYVTHEKG HFIYFYIGPL AFLVFKTA