ID   DYL1_KLULA              Reviewed;          87 AA.
AC   Q6CWX4;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Dynein light chain 1, cytoplasmic;
GN   Name=DYN2; OrderedLocusNames=KLLA0B00781g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Acts as one of several non-catalytic accessory components of
CC       the cytoplasmic dynein complex that are thought to be involved in
CC       linking dynein to cargos and to adapter proteins that regulate dynein
CC       function. Cytoplasmic dynein 1 acts as a motor for the intracellular
CC       retrograde motility of vesicles and organelles along microtubules. May
CC       play a role in changing or maintaining the spatial distribution of
CC       cytoskeletal structures (By similarity). Also a component of the
CC       nuclear pore complex (By similarity). {ECO:0000250,
CC       ECO:0000250|UniProtKB:Q02647}.
CC   -!- SUBUNIT: Homodimer. Cytoplasmic dynein consists of two catalytic heavy
CC       chains (HCs) and a number of non-catalytic subunits which present
CC       intermediate chains (ICs), light intermediate chains (LICs) and light
CC       chains (LCs). Component of the nuclear pore complex (NPC). NPC
CC       constitutes the exclusive means of nucleocytoplasmic transport. NPCs
CC       allow the passive diffusion of ions and small molecules and the active,
CC       nuclear transport receptor-mediated bidirectional transport of
CC       macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and
CC       ribosomal subunits across the nuclear envelope. Due to its 8-fold
CC       rotational symmetry, all subunits are present with 8 copies or
CC       multiples thereof. {ECO:0000250|UniProtKB:Q02647}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q02647}. Nucleus, nuclear pore complex
CC       {ECO:0000250|UniProtKB:Q02647}.
CC   -!- SIMILARITY: Belongs to the dynein light chain family. {ECO:0000305}.
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DR   EMBL; CR382122; CAH01958.1; -; Genomic_DNA.
DR   RefSeq; XP_451565.1; XM_451565.1.
DR   AlphaFoldDB; Q6CWX4; -.
DR   SMR; Q6CWX4; -.
DR   STRING; 28985.XP_451565.1; -.
DR   EnsemblFungi; CAH01958; CAH01958; KLLA0_B00781g.
DR   GeneID; 2897493; -.
DR   KEGG; kla:KLLA0_B00781g; -.
DR   eggNOG; KOG3430; Eukaryota.
DR   HOGENOM; CLU_070944_4_0_1; -.
DR   InParanoid; Q6CWX4; -.
DR   OMA; RHGATWH; -.
DR   Proteomes; UP000000598; Chromosome B.
DR   GO; GO:0005868; C:cytoplasmic dynein complex; IEA:EnsemblFungi.
DR   GO; GO:0005881; C:cytoplasmic microtubule; IEA:EnsemblFungi.
DR   GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR   GO; GO:1990429; C:peroxisomal importomer complex; IEA:EnsemblFungi.
DR   GO; GO:0005777; C:peroxisome; IEA:EnsemblFungi.
DR   GO; GO:0008574; F:plus-end-directed microtubule motor activity; IEA:EnsemblFungi.
DR   GO; GO:0044877; F:protein-containing complex binding; IEA:EnsemblFungi.
DR   GO; GO:0040001; P:establishment of mitotic spindle localization; IEA:EnsemblFungi.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0030473; P:nuclear migration along microtubule; IEA:EnsemblFungi.
DR   GO; GO:0051292; P:nuclear pore complex assembly; IEA:EnsemblFungi.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.740.10; -; 1.
DR   InterPro; IPR037177; DLC_sf.
DR   InterPro; IPR019763; Dynein_light_1/2_CS.
DR   InterPro; IPR001372; Dynein_light_chain_typ-1/2.
DR   PANTHER; PTHR11886; PTHR11886; 1.
DR   Pfam; PF01221; Dynein_light; 1.
DR   SMART; SM01375; Dynein_light; 1.
DR   SUPFAM; SSF54648; SSF54648; 1.
DR   PROSITE; PS01239; DYNEIN_LIGHT_1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Cytoskeleton; Dynein; Microtubule; Motor protein;
KW   mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW   Reference proteome; Translocation; Transport.
FT   CHAIN           1..87
FT                   /note="Dynein light chain 1, cytoplasmic"
FT                   /id="PRO_0000195147"
SQ   SEQUENCE   87 AA;  9942 MW;  1D4CE90DEFE1F25F CRC64;
     MSKPVLKASD ITDELRDEIF ELSSNATANY KLEREIAAYI KKQLDVSQGE TWHVIVGKNF
     GSYVTHEKGY FVYFYIGPLA FLVFKTA