ID   DYL2_BOVIN              Reviewed;          89 AA.
AC   Q3MHR3;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Dynein light chain 2, cytoplasmic;
GN   Name=DYNLL2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as one of several non-catalytic accessory components of
CC       the cytoplasmic dynein 1 complex that are thought to be involved in
CC       linking dynein to cargos and to adapter proteins that regulate dynein
CC       function. Cytoplasmic dynein 1 acts as a motor for the intracellular
CC       retrograde motility of vesicles and organelles along microtubules. May
CC       be involved in some aspects of dynein-related intracellular transport
CC       and motility. May play a role in changing or maintaining the spatial
CC       distribution of cytoskeletal structures (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. The cytoplasmic dynein 1 complex consists of two
CC       catalytic heavy chains (HCs) and a number of non-catalytic subunits
CC       which present intermediate chains (ICs), light intermediate chains
CC       (LICs) and light chains (LCs); the composition seems to vary in respect
CC       to the IC, LIC and LC composition. The heavy chain homodimer serves as
CC       a scaffold for the probable homodimeric assembly of the respective non-
CC       catalytic subunits. Dynein ICs and LICs bind directly to the HC dimer
CC       and the LCs assemble on the IC dimer. Interacts with DYNC1I1. Interacts
CC       with BMF. Component of the myosin V motor complex. Interacts with
CC       BCAS1. Interacts with Basson/BSN (By similarity). Interacts with
CC       Basson/BSN (By similarity). Interacts with AMBRA1 (via TQT motifs);
CC       tethering AMBRA1 to the cytoskeleton (By similarity).
CC       {ECO:0000250|UniProtKB:Q78P75, ECO:0000250|UniProtKB:Q96FJ2,
CC       ECO:0000250|UniProtKB:Q9D0M5}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q96FJ2}.
CC   -!- SIMILARITY: Belongs to the dynein light chain family. {ECO:0000305}.
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DR   EMBL; BC105140; AAI05141.1; -; mRNA.
DR   RefSeq; NP_001106774.1; NM_001113303.1.
DR   AlphaFoldDB; Q3MHR3; -.
DR   SMR; Q3MHR3; -.
DR   STRING; 9913.ENSBTAP00000006190; -.
DR   PaxDb; Q3MHR3; -.
DR   PeptideAtlas; Q3MHR3; -.
DR   PRIDE; Q3MHR3; -.
DR   Ensembl; ENSBTAT00000006190; ENSBTAP00000006190; ENSBTAG00000025313.
DR   GeneID; 540369; -.
DR   KEGG; bta:540369; -.
DR   CTD; 140735; -.
DR   VEuPathDB; HostDB:ENSBTAG00000025313; -.
DR   VGNC; VGNC:28275; DYNLL2.
DR   eggNOG; KOG3430; Eukaryota.
DR   GeneTree; ENSGT00390000000378; -.
DR   HOGENOM; CLU_070944_4_0_1; -.
DR   InParanoid; Q3MHR3; -.
DR   OMA; RHGATWH; -.
DR   OrthoDB; 1520814at2759; -.
DR   TreeFam; TF300264; -.
DR   Reactome; R-BTA-139910; Activation of BMF and translocation to mitochondria.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000025313; Expressed in temporal cortex and 104 other tissues.
DR   GO; GO:0097731; C:9+0 non-motile cilium; IEA:Ensembl.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005868; C:cytoplasmic dynein complex; IBA:GO_Central.
DR   GO; GO:0005856; C:cytoskeleton; ISS:UniProtKB.
DR   GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0031475; C:myosin V complex; IEA:Ensembl.
DR   GO; GO:0098794; C:postsynapse; IEA:Ensembl.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IBA:GO_Central.
DR   GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR   Gene3D; 3.30.740.10; -; 1.
DR   InterPro; IPR037177; DLC_sf.
DR   InterPro; IPR019763; Dynein_light_1/2_CS.
DR   InterPro; IPR001372; Dynein_light_chain_typ-1/2.
DR   PANTHER; PTHR11886; PTHR11886; 1.
DR   Pfam; PF01221; Dynein_light; 1.
DR   SMART; SM01375; Dynein_light; 1.
DR   SUPFAM; SSF54648; SSF54648; 1.
DR   PROSITE; PS01239; DYNEIN_LIGHT_1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Cytoskeleton; Dynein; Microtubule; Motor protein;
KW   Reference proteome; Transport.
FT   CHAIN           1..89
FT                   /note="Dynein light chain 2, cytoplasmic"
FT                   /id="PRO_0000244522"
FT   SITE            41
FT                   /note="Interaction with myosin V motor complex"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   89 AA;  10350 MW;  45364D32C0077F8E CRC64;
     MSDRKAVIKN ADMSEDMQQD AVDCATQAME KYNIEKDIAA YIKKEFDKKY NPTWHCIVGR
     NFGSYVTHET KHFIYFYLGQ VAILLFKSG