ID   DYL2_DROME              Reviewed;          89 AA.
AC   O96860; A4UZY5; C6SUZ4; Q541G4;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 160.
DE   RecName: Full=Dynein light chain 2, cytoplasmic;
DE   AltName: Full=8 kDa dynein light chain;
GN   Name=Cdlc2; ORFNames=CG5450;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RA   Li M.-G., Serr M., Hays T.S.;
RL   Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Larva, and Pupae;
RA   Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Booth B.,
RA   Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E.,
RA   George R.A., Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G.,
RA   Miranda A., Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S.,
RA   Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M.,
RA   Celniker S.E.;
RL   Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a non-catalytic accessory component of a dynein
CC       complex. {ECO:0000250}.
CC   -!- INTERACTION:
CC       O96860; Q6NMT8: Dmel\CG11125; NbExp=4; IntAct=EBI-146410, EBI-175261;
CC       O96860; Q058Z8: Dmel\CG30324; NbExp=4; IntAct=EBI-146410, EBI-148486;
CC       O96860; Q7JX41: geminin; NbExp=6; IntAct=EBI-146410, EBI-88763;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the dynein light chain family. {ECO:0000305}.
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DR   EMBL; U48847; AAD00073.1; -; mRNA.
DR   EMBL; AE014134; AAF51383.1; -; Genomic_DNA.
DR   EMBL; AE014134; AAN10465.1; -; Genomic_DNA.
DR   EMBL; AY069718; AAL39863.1; -; mRNA.
DR   EMBL; BT088986; ACT88127.1; -; mRNA.
DR   RefSeq; NP_001245836.1; NM_001258907.2.
DR   RefSeq; NP_477408.1; NM_058060.4.
DR   RefSeq; NP_722698.1; NM_164412.2.
DR   AlphaFoldDB; O96860; -.
DR   BMRB; O96860; -.
DR   SMR; O96860; -.
DR   BioGRID; 59568; 43.
DR   DIP; DIP-17518N; -.
DR   IntAct; O96860; 16.
DR   STRING; 7227.FBpp0077590; -.
DR   PaxDb; O96860; -.
DR   DNASU; 33319; -.
DR   EnsemblMetazoa; FBtr0077924; FBpp0077590; FBgn0026141.
DR   EnsemblMetazoa; FBtr0077925; FBpp0077591; FBgn0026141.
DR   EnsemblMetazoa; FBtr0305553; FBpp0294004; FBgn0026141.
DR   GeneID; 33319; -.
DR   KEGG; dme:Dmel_CG5450; -.
DR   CTD; 33319; -.
DR   FlyBase; FBgn0026141; Cdlc2.
DR   VEuPathDB; VectorBase:FBgn0026141; -.
DR   eggNOG; KOG3430; Eukaryota.
DR   GeneTree; ENSGT00390000000378; -.
DR   HOGENOM; CLU_070944_4_0_1; -.
DR   InParanoid; O96860; -.
DR   OMA; RHGATWH; -.
DR   OrthoDB; 1520814at2759; -.
DR   PhylomeDB; O96860; -.
DR   BioGRID-ORCS; 33319; 0 hits in 3 CRISPR screens.
DR   GenomeRNAi; 33319; -.
DR   PRO; PR:O96860; -.
DR   Proteomes; UP000000803; Chromosome 2L.
DR   Bgee; FBgn0026141; Expressed in testis and 9 other tissues.
DR   ExpressionAtlas; O96860; baseline and differential.
DR   Genevisible; O96860; DM.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005868; C:cytoplasmic dynein complex; IBA:GO_Central.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IBA:GO_Central.
DR   GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR   Gene3D; 3.30.740.10; -; 1.
DR   InterPro; IPR037177; DLC_sf.
DR   InterPro; IPR019763; Dynein_light_1/2_CS.
DR   InterPro; IPR001372; Dynein_light_chain_typ-1/2.
DR   PANTHER; PTHR11886; PTHR11886; 1.
DR   Pfam; PF01221; Dynein_light; 1.
DR   SMART; SM01375; Dynein_light; 1.
DR   SUPFAM; SSF54648; SSF54648; 1.
DR   PROSITE; PS01239; DYNEIN_LIGHT_1; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Cytoskeleton; Dynein; Microtubule; Motor protein;
KW   Reference proteome.
FT   CHAIN           1..89
FT                   /note="Dynein light chain 2, cytoplasmic"
FT                   /id="PRO_0000195135"
SQ   SEQUENCE   89 AA;  10358 MW;  538C7661E0423A8F CRC64;
     MSDRKAVIKN ADMSEEMQQD AVDCATQALE KYNIEKDIAA FIKKEFDKKY NPTWHCIVGR
     NFGSYVTHET RHFIYFYLGQ VAILLFKSG