DYLT2_HUMAN
ID DYLT2_HUMAN Reviewed; 198 AA.
AC Q8IZS6;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Dynein light chain Tctex-type protein 2 {ECO:0000305};
DE AltName: Full=T-complex testis-specific protein 3;
DE AltName: Full=T-complex-associated testis-expressed protein 3;
DE Short=Tcte-3;
DE AltName: Full=Tctex1 domain-containing protein 3;
GN Name=DYNLT2 {ECO:0000312|HGNC:HGNC:11695}; Synonyms=TCTE3, TCTEX1D3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-67 AND ILE-88, TISSUE SPECIFICITY,
RP AND POSSIBLE FUNCTION IN AXONEMAL DYNEIN.
RX PubMed=12584439; DOI=10.1159/000068545;
RA Neesen J., Drenckhahn J.-D., Tiede S., Burfeind P., Grzmil M.,
RA Konietzko J., Dixkens C., Kreutzberger J., Laccone F., Omran H.;
RT "Identification of the human ortholog of the T-complex-encoded protein
RT TCTE3 and evaluation as a candidate gene for primary ciliary dyskinesia.";
RL Cytogenet. Genome Res. 98:38-44(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP TISSUE SPECIFICITY, AND POSSIBLE FUNCTION IN AXONEMAL DYNEIN AND
RP CYTOPLASMIC DYNEIN 1.
RX PubMed=11278908; DOI=10.1074/jbc.m011456200;
RA DiBella L.M., Benashski S.E., Tedford H.W., Harrison A., Patel-King R.S.,
RA King S.M.;
RT "The Tctex1/Tctex2 class of dynein light chains. Dimerization, differential
RT expression, and interaction with the LC8 protein family.";
RL J. Biol. Chem. 276:14366-14373(2001).
CC -!- FUNCTION: May be an accessory component of axonemal dynein and
CC cytoplasmic dynein 1 (PubMed:11278908, PubMed:12584439). Candidate for
CC involvement in male sterility (By similarity).
CC {ECO:0000250|UniProtKB:P11985, ECO:0000269|PubMed:11278908,
CC ECO:0000269|PubMed:12584439}.
CC -!- SUBUNIT: Interacts with CSNK2B. {ECO:0000250|UniProtKB:P11985}.
CC -!- INTERACTION:
CC Q8IZS6; Q9UHG0: DCDC2; NbExp=3; IntAct=EBI-22730131, EBI-10303987;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:P11985}. Cytoplasmic granule
CC {ECO:0000250|UniProtKB:P11985}. Membrane
CC {ECO:0000250|UniProtKB:P11985}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:P11985}. Note=Found on the surface of sperm
CC tail. Stored in cytoplasmic granules during spermatogenesis.
CC {ECO:0000250|UniProtKB:P11985}.
CC -!- TISSUE SPECIFICITY: Expressed predominantly in testis. Also expressed
CC in brain, lung and trachea. {ECO:0000269|PubMed:11278908,
CC ECO:0000269|PubMed:12584439}.
CC -!- SIMILARITY: Belongs to the dynein light chain Tctex-type family.
CC {ECO:0000305}.
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DR EMBL; AF519569; AAN34631.1; -; mRNA.
DR EMBL; AL354892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471051; EAW47439.1; -; Genomic_DNA.
DR EMBL; BC113639; AAI13640.1; -; mRNA.
DR CCDS; CCDS5310.1; -.
DR RefSeq; NP_777570.1; NM_174910.2.
DR RefSeq; XP_011534395.1; XM_011536093.2.
DR AlphaFoldDB; Q8IZS6; -.
DR SMR; Q8IZS6; -.
DR BioGRID; 112851; 2.
DR IntAct; Q8IZS6; 1.
DR STRING; 9606.ENSP00000355736; -.
DR iPTMnet; Q8IZS6; -.
DR PhosphoSitePlus; Q8IZS6; -.
DR BioMuta; TCTE3; -.
DR DMDM; 74750798; -.
DR jPOST; Q8IZS6; -.
DR MassIVE; Q8IZS6; -.
DR PaxDb; Q8IZS6; -.
DR PeptideAtlas; Q8IZS6; -.
DR PRIDE; Q8IZS6; -.
DR ProteomicsDB; 71419; -.
DR Antibodypedia; 33575; 27 antibodies from 16 providers.
DR DNASU; 6991; -.
DR Ensembl; ENST00000366774.4; ENSP00000355736.3; ENSG00000184786.6.
DR Ensembl; ENST00000610291.2; ENSP00000478684.1; ENSG00000275368.2.
DR GeneID; 6991; -.
DR KEGG; hsa:6991; -.
DR MANE-Select; ENST00000366774.4; ENSP00000355736.3; NM_174910.3; NP_777570.1.
DR UCSC; uc003qxe.2; human.
DR CTD; 6991; -.
DR DisGeNET; 6991; -.
DR GeneCards; DYNLT2; -.
DR HGNC; HGNC:11695; DYNLT2.
DR HPA; ENSG00000184786; Tissue enriched (testis).
DR MIM; 186977; gene.
DR neXtProt; NX_Q8IZS6; -.
DR OpenTargets; ENSG00000184786; -.
DR VEuPathDB; HostDB:ENSG00000184786; -.
DR eggNOG; KOG4108; Eukaryota.
DR GeneTree; ENSGT00940000160069; -.
DR HOGENOM; CLU_097204_0_0_1; -.
DR InParanoid; Q8IZS6; -.
DR OMA; YANTYRM; -.
DR OrthoDB; 1456915at2759; -.
DR PhylomeDB; Q8IZS6; -.
DR TreeFam; TF313904; -.
DR PathwayCommons; Q8IZS6; -.
DR Reactome; R-HSA-5620924; Intraflagellar transport.
DR SignaLink; Q8IZS6; -.
DR BioGRID-ORCS; 6991; 9 hits in 1069 CRISPR screens.
DR ChiTaRS; TCTE3; human.
DR GenomeRNAi; 6991; -.
DR Pharos; Q8IZS6; Tdark.
DR PRO; PR:Q8IZS6; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q8IZS6; protein.
DR Bgee; ENSG00000184786; Expressed in left testis and 90 other tissues.
DR Genevisible; Q8IZS6; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005868; C:cytoplasmic dynein complex; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IBA:GO_Central.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR Gene3D; 3.30.1140.40; -; 1.
DR InterPro; IPR005334; Tctex-1-like.
DR InterPro; IPR038586; Tctex-1-like_sf.
DR PANTHER; PTHR21255; PTHR21255; 1.
DR Pfam; PF03645; Tctex-1; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoskeleton; Dynein; Membrane; Microtubule; Motor protein;
KW Reference proteome; Transport.
FT CHAIN 1..198
FT /note="Dynein light chain Tctex-type protein 2"
FT /id="PRO_0000328728"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 67
FT /note="I -> V (in dbSNP:rs116980543)"
FT /evidence="ECO:0000269|PubMed:12584439"
FT /id="VAR_042499"
FT VARIANT 88
FT /note="R -> I (in dbSNP:rs2027063)"
FT /evidence="ECO:0000269|PubMed:12584439"
FT /id="VAR_042500"
FT VARIANT 121
FT /note="V -> A (in dbSNP:rs13194101)"
FT /id="VAR_042501"
SQ SEQUENCE 198 AA; 23176 MW; FC20E7C32510111D CRC64;
MEKRGRGVKS SPIQTPNQTP QQAPVTPRKE RRPSMFEKEA YTQILRERLR ESIHNVQYVE
PPFDDSIADI GKEWKSALAK LKFANSYRME PLKKFQAHSV ETKVQQILTE SLKDVKYDDK
VFSHLSLELA DRILLAVKEF GYHRYKFIIK VLFIQKTGQA INIASRWIWD IAWDSWVAAK
HEAESYVALV LVFALYYE
