DYLT3_HUMAN
ID DYLT3_HUMAN Reviewed; 116 AA.
AC P51808; Q6ICS3;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Dynein light chain Tctex-type 3;
DE AltName: Full=Protein 91/23;
DE AltName: Full=T-complex-associated testis-expressed 1-like;
GN Name=DYNLT3; Synonyms=TCTE1L, TCTE1XL;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8004092; DOI=10.1093/hmg/3.2.257;
RA Roux A.-F., Rommens J., McDowell C., Anson-Cartwright L., Bell S.,
RA Schappert K.T., Fishman G.A., Musarella M.;
RT "Identification of a gene from Xp21 with similarity to the tctex-1 gene of
RT the murine t complex.";
RL Hum. Mol. Genet. 3:257-263(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Subthalamic nucleus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP INTERACTION WITH SATB1, AND SUBCELLULAR LOCATION.
RX PubMed=16079286; DOI=10.1242/jcs.02472;
RA Yeh T.-Y., Chuang J.-Z., Sung C.-H.;
RT "Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional
RT modulator in a dynein-independent pathway.";
RL J. Cell Sci. 118:3431-3443(2005).
RN [7]
RP INTERACTION WITH BUB3, AND SUBCELLULAR LOCATION.
RX PubMed=17289665; DOI=10.1074/jbc.m611279200;
RA Lo K.W., Kogoy J.M., Pfister K.K.;
RT "The DYNLT3 light chain directly links cytoplasmic dynein to a spindle
RT checkpoint protein, Bub3.";
RL J. Biol. Chem. 282:11205-11212(2007).
CC -!- FUNCTION: Acts as one of several non-catalytic accessory components of
CC the cytoplasmic dynein 1 complex that are thought to be involved in
CC linking dynein to cargos and to adapter proteins that regulate dynein
CC function. Cytoplasmic dynein 1 acts as a motor for the intracellular
CC retrograde motility of vesicles and organelles along microtubules.
CC Probably binds BUB3 as part of transport cargo. Required for the
CC efficient progression through mitosis (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. The cytoplasmic dynein 1 complex consists of two
CC catalytic heavy chains (HCs) and a number of non-catalytic subunits
CC presented by intermediate chains (ICs), light intermediate chains
CC (LICs) and light chains (LCs); the composition seems to vary in respect
CC to the IC, LIC and LC composition. The heavy chain homodimer serves as
CC a scaffold for the probable homodimeric assembly of the respective non-
CC catalytic subunits. The ICs and LICs bind directly to the HC dimer and
CC the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for
CC association with dynein IC (DYNC1I1 or DYNC1I2). Self-associates.
CC Interacts with DYNC1I1 and DYNC1I2 (By similarity). Interacts with
CC BUB3. Interacts with SATB1 in nucleus to form complex with matrix
CC attachment regions (MARs) of DNA. {ECO:0000250,
CC ECO:0000269|PubMed:16079286, ECO:0000269|PubMed:17289665}.
CC -!- INTERACTION:
CC P51808; Q8WU43: C2orf15; NbExp=3; IntAct=EBI-743027, EBI-12904676;
CC P51808; Q9NRJ3: CCL28; NbExp=3; IntAct=EBI-743027, EBI-7783254;
CC P51808; Q13409-3: DYNC1I2; NbExp=3; IntAct=EBI-743027, EBI-12094038;
CC P51808; P63172: DYNLT1; NbExp=4; IntAct=EBI-743027, EBI-1176455;
CC P51808; P51808: DYNLT3; NbExp=7; IntAct=EBI-743027, EBI-743027;
CC P51808; Q9GZT8: NIF3L1; NbExp=3; IntAct=EBI-743027, EBI-740897;
CC P51808; P54277-2: PMS1; NbExp=3; IntAct=EBI-743027, EBI-12402645;
CC P51808; Q6PJT7-6: ZC3H14; NbExp=3; IntAct=EBI-743027, EBI-12147703;
CC -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton. Chromosome,
CC centromere, kinetochore. Note=Colocalizes with BUB3 at kinetochores
CC specifically during prometaphase.
CC -!- SIMILARITY: Belongs to the dynein light chain Tctex-type family.
CC {ECO:0000305}.
CC -!- CAUTION: Was originally thought to be a candidate for RP3.
CC {ECO:0000305|PubMed:8004092}.
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DR EMBL; U02556; AAA57444.1; -; mRNA.
DR EMBL; AK311851; BAG34793.1; -; mRNA.
DR EMBL; CR450320; CAG29316.1; -; mRNA.
DR EMBL; CR542213; CAG47009.1; -; mRNA.
DR EMBL; CH471141; EAW59452.1; -; Genomic_DNA.
DR EMBL; BC000968; AAH00968.1; -; mRNA.
DR CCDS; CCDS14243.1; -.
DR PIR; I38410; I38410.
DR RefSeq; NP_006511.1; NM_006520.2.
DR AlphaFoldDB; P51808; -.
DR SMR; P51808; -.
DR BioGRID; 112850; 25.
DR CORUM; P51808; -.
DR IntAct; P51808; 17.
DR STRING; 9606.ENSP00000367841; -.
DR CarbonylDB; P51808; -.
DR GlyGen; P51808; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; P51808; -.
DR PhosphoSitePlus; P51808; -.
DR BioMuta; DYNLT3; -.
DR EPD; P51808; -.
DR jPOST; P51808; -.
DR MassIVE; P51808; -.
DR PaxDb; P51808; -.
DR PeptideAtlas; P51808; -.
DR PRIDE; P51808; -.
DR ProteomicsDB; 56402; -.
DR Antibodypedia; 10567; 95 antibodies from 22 providers.
DR DNASU; 6990; -.
DR Ensembl; ENST00000378578.9; ENSP00000367841.4; ENSG00000165169.11.
DR GeneID; 6990; -.
DR KEGG; hsa:6990; -.
DR MANE-Select; ENST00000378578.9; ENSP00000367841.4; NM_006520.3; NP_006511.1.
DR UCSC; uc004dds.4; human.
DR CTD; 6990; -.
DR DisGeNET; 6990; -.
DR GeneCards; DYNLT3; -.
DR HGNC; HGNC:11694; DYNLT3.
DR HPA; ENSG00000165169; Low tissue specificity.
DR MIM; 300302; gene.
DR neXtProt; NX_P51808; -.
DR OpenTargets; ENSG00000165169; -.
DR PharmGKB; PA36414; -.
DR VEuPathDB; HostDB:ENSG00000165169; -.
DR eggNOG; KOG4081; Eukaryota.
DR GeneTree; ENSGT00940000155009; -.
DR HOGENOM; CLU_097204_7_0_1; -.
DR InParanoid; P51808; -.
DR OMA; LWENSTI; -.
DR OrthoDB; 1474572at2759; -.
DR PhylomeDB; P51808; -.
DR TreeFam; TF313904; -.
DR PathwayCommons; P51808; -.
DR SignaLink; P51808; -.
DR BioGRID-ORCS; 6990; 10 hits in 709 CRISPR screens.
DR ChiTaRS; DYNLT3; human.
DR GeneWiki; DYNLT3; -.
DR GenomeRNAi; 6990; -.
DR Pharos; P51808; Tbio.
DR PRO; PR:P51808; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; P51808; protein.
DR Bgee; ENSG00000165169; Expressed in gingiva and 210 other tissues.
DR ExpressionAtlas; P51808; baseline and differential.
DR Genevisible; P51808; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005868; C:cytoplasmic dynein complex; IDA:UniProtKB.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0061673; C:mitotic spindle astral microtubule; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0045505; F:dynein intermediate chain binding; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR GO; GO:0045931; P:positive regulation of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0007346; P:regulation of mitotic cell cycle; ISS:UniProtKB.
DR Gene3D; 3.30.1140.40; -; 1.
DR InterPro; IPR005334; Tctex-1-like.
DR InterPro; IPR038586; Tctex-1-like_sf.
DR PANTHER; PTHR21255; PTHR21255; 1.
DR Pfam; PF03645; Tctex-1; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Centromere; Chromosome; Cytoplasm; Cytoskeleton;
KW Dynein; Kinetochore; Microtubule; Mitosis; Motor protein; Nitration;
KW Nucleus; Reference proteome; Transport.
FT CHAIN 1..116
FT /note="Dynein light chain Tctex-type 3"
FT /id="PRO_0000195158"
FT MOD_RES 4
FT /note="3'-nitrotyrosine"
FT /evidence="ECO:0000250|UniProtKB:P56387"
SQ SEQUENCE 116 AA; 13062 MW; 7DEB2A8B9D989632 CRC64;
MEEYHRHCDE VGFNAEEAHN IVKECVDGVL GGEDYNHNNI NQWTASIVEQ SLTHLVKLGK
AYKYIVTCAV VQKSAYGFHT ASSCFWDTTS DGTCTVRWEN RTMNCIVNVF AIAIVL