DYLT4_MOUSE
ID DYLT4_MOUSE Reviewed; 219 AA.
AC Q8CDY7; A2AE79; A2AE80; Q14C28;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Dynein light chain Tctex-type 4;
DE AltName: Full=Tctex1 domain-containing protein 4;
GN Name=Dynlt4; Synonyms=Tctex1d4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX PubMed=23789093; DOI=10.1242/bio.20131065;
RA Korrodi-Gregorio L., Vieira S.I., Esteves S.L., Silva J.V., Freitas M.J.,
RA Brauns A.K., Luers G., Abrantes J., Esteves P.J., da Cruz e Silva O.A.,
RA Fardilha M., da Cruz e Silva E.F.;
RT "TCTEX1D4, a novel protein phosphatase 1 interactor: connecting the
RT phosphatase to the microtubule network.";
RL Biol. Open 2:453-465(2013).
CC -!- SUBUNIT: Interacts with ENG/endoglin, TGFBR2 and TGFBR3. Interacts with
CC PPP1CC. {ECO:0000250|UniProtKB:Q5JR98}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000250|UniProtKB:Q5JR98}. Cytoplasmic vesicle, secretory vesicle,
CC acrosome {ECO:0000269|PubMed:23789093}. Cytoplasm, cytoskeleton, cilium
CC axoneme {ECO:0000250|UniProtKB:Q5JR98}. Cytoplasm
CC {ECO:0000269|PubMed:23789093}. Nucleus {ECO:0000269|PubMed:23789093}.
CC Cytoplasm, cytoskeleton, microtubule organizing center
CC {ECO:0000250|UniProtKB:Q5JR98}. Note=Present along the entire length of
CC the flagellum, including principal and endpiece, and more predominantly
CC in the midpiece region. {ECO:0000250|UniProtKB:Q5JR98}.
CC -!- DEVELOPMENTAL STAGE: Expression is elevated in spermatocytes, this
CC expression is maintained high in the round spermatids with a decreased
CC in elongated spermatid. {ECO:0000269|PubMed:23789093}.
CC -!- SIMILARITY: Belongs to the dynein light chain Tctex-type family.
CC {ECO:0000305}.
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DR EMBL; AK029345; BAC26409.1; -; mRNA.
DR EMBL; AL671866; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC115474; AAI15475.1; -; mRNA.
DR CCDS; CCDS18528.1; -.
DR RefSeq; NP_778195.1; NM_175030.2.
DR RefSeq; XP_006503160.1; XM_006503097.3.
DR RefSeq; XP_006503161.1; XM_006503098.3.
DR RefSeq; XP_006503162.1; XM_006503099.3.
DR RefSeq; XP_006503163.1; XM_006503100.3.
DR AlphaFoldDB; Q8CDY7; -.
DR SMR; Q8CDY7; -.
DR STRING; 10090.ENSMUSP00000052243; -.
DR iPTMnet; Q8CDY7; -.
DR PhosphoSitePlus; Q8CDY7; -.
DR MaxQB; Q8CDY7; -.
DR PaxDb; Q8CDY7; -.
DR PRIDE; Q8CDY7; -.
DR ProteomicsDB; 263259; -.
DR Antibodypedia; 32555; 65 antibodies from 21 providers.
DR Ensembl; ENSMUST00000062206; ENSMUSP00000052243; ENSMUSG00000047671.
DR GeneID; 242646; -.
DR KEGG; mmu:242646; -.
DR UCSC; uc008uia.1; mouse.
DR CTD; 343521; -.
DR MGI; MGI:3045358; Dynlt4.
DR VEuPathDB; HostDB:ENSMUSG00000047671; -.
DR eggNOG; KOG4108; Eukaryota.
DR GeneTree; ENSGT00940000162474; -.
DR HOGENOM; CLU_097204_1_1_1; -.
DR InParanoid; Q8CDY7; -.
DR OMA; CPPRYKL; -.
DR OrthoDB; 1435776at2759; -.
DR PhylomeDB; Q8CDY7; -.
DR TreeFam; TF313904; -.
DR BioGRID-ORCS; 242646; 3 hits in 73 CRISPR screens.
DR PRO; PR:Q8CDY7; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8CDY7; protein.
DR Bgee; ENSMUSG00000047671; Expressed in granulocyte and 23 other tissues.
DR ExpressionAtlas; Q8CDY7; baseline and differential.
DR Genevisible; Q8CDY7; MM.
DR GO; GO:0001669; C:acrosomal vesicle; IDA:MGI.
DR GO; GO:0005930; C:axoneme; IDA:MGI.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005868; C:cytoplasmic dynein complex; IBA:GO_Central.
DR GO; GO:0005815; C:microtubule organizing center; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0036126; C:sperm flagellum; ISO:MGI.
DR GO; GO:0045505; F:dynein intermediate chain binding; IBA:GO_Central.
DR GO; GO:0008157; F:protein phosphatase 1 binding; ISO:MGI.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR Gene3D; 3.30.1140.40; -; 1.
DR InterPro; IPR005334; Tctex-1-like.
DR InterPro; IPR038586; Tctex-1-like_sf.
DR PANTHER; PTHR21255; PTHR21255; 1.
DR Pfam; PF03645; Tctex-1; 1.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton;
KW Flagellum; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..219
FT /note="Dynein light chain Tctex-type 4"
FT /id="PRO_0000316871"
FT REGION 1..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 64
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 82
FT /note="V -> M (in Ref. 3; AAI15475)"
FT /evidence="ECO:0000305"
FT CONFLICT 109
FT /note="E -> D (in Ref. 3; AAI15475)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 219 AA; 23451 MW; C1F15926C6CAB4B4 CRC64;
MACRTLPSRR QEEETTKDLA LKLPPGKPGG HLPSIDETRP IGPGPASRRG SLPGLHPSFS
RRNSLAGPLV GPGGRRPSLG PVPPLGSRVS FSGLPLMLPR RMAPSYRLEP APGEHWEAAG
AQRALEAALT TQLNGVCYCG SEAGKLVQAL CEQIHTRVRE LNLPRYKLVC NVVLGPREGQ
GVHVVSRALW DAVHDGLASA TFTNPSLFAV ATVHAVYWE
