DYLT4_PIG
ID DYLT4_PIG Reviewed; 219 AA.
AC Q4VYA0;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 57.
DE RecName: Full=Dynein light chain Tctex-type 4;
DE AltName: Full=Protein N22.1;
DE AltName: Full=Tctex-2-beta;
DE AltName: Full=Tctex1 domain-containing protein 4;
GN Name=DYNLT4; Synonyms=TCTEX1D4;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lung, and Uterus;
RX PubMed=16982625; DOI=10.1074/jbc.m608614200;
RA Meng Q.-J., Lux A., Holloschi A., Li J., Hughes J.M.X., Foerg T.,
RA McCarthy J.E.G., Heagerty A.M., Kioschis P., Hafner M., Garland J.M.;
RT "Identification of Tctex2beta, a novel dynein light chain family member
RT that interacts with different transforming growth factor-beta receptors.";
RL J. Biol. Chem. 281:37069-37080(2006).
CC -!- SUBUNIT: Interacts with ENG/endoglin, TGFBR2 and TGFBR3. Interacts with
CC PPP1CC. {ECO:0000250|UniProtKB:Q5JR98}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000250|UniProtKB:Q5JR98}. Cytoplasmic vesicle, secretory vesicle,
CC acrosome {ECO:0000250|UniProtKB:Q5JR98}. Cytoplasm, cytoskeleton,
CC cilium axoneme {ECO:0000250|UniProtKB:Q5JR98}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q5JR98}. Nucleus {ECO:0000250|UniProtKB:Q5JR98}.
CC Cytoplasm, cytoskeleton, microtubule organizing center
CC {ECO:0000250|UniProtKB:Q5JR98}. Note=Present along the entire length of
CC the flagellum, including principal and endpiece, and more predominantly
CC in the midpiece region. {ECO:0000250|UniProtKB:Q5JR98}.
CC -!- SIMILARITY: Belongs to the dynein light chain Tctex-type family.
CC {ECO:0000305}.
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DR EMBL; AJ973122; CAJ00222.1; -; mRNA.
DR RefSeq; NP_001027527.1; NM_001032356.1.
DR AlphaFoldDB; Q4VYA0; -.
DR SMR; Q4VYA0; -.
DR STRING; 9823.ENSSSCP00000004243; -.
DR PaxDb; Q4VYA0; -.
DR GeneID; 606747; -.
DR KEGG; ssc:606747; -.
DR CTD; 343521; -.
DR eggNOG; KOG4108; Eukaryota.
DR InParanoid; Q4VYA0; -.
DR OrthoDB; 1435776at2759; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0001669; C:acrosomal vesicle; ISS:UniProtKB.
DR GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005868; C:cytoplasmic dynein complex; IBA:GO_Central.
DR GO; GO:0005815; C:microtubule organizing center; ISS:UniProtKB.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0045505; F:dynein intermediate chain binding; IBA:GO_Central.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR Gene3D; 3.30.1140.40; -; 1.
DR InterPro; IPR005334; Tctex-1-like.
DR InterPro; IPR038586; Tctex-1-like_sf.
DR PANTHER; PTHR21255; PTHR21255; 1.
DR Pfam; PF03645; Tctex-1; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton;
KW Flagellum; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..219
FT /note="Dynein light chain Tctex-type 4"
FT /id="PRO_0000316873"
FT REGION 1..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 64
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8CDY7"
SQ SEQUENCE 219 AA; 22840 MW; E38D733E85B96B8F CRC64;
MAGRPVPAGR QEEELAKDPG QKLSLARPPG RLPSIDETRP AGPGPASRRG SVLGPASSFS
RRNSLAGAGA GPGGRRPSLG PVPPLGWRVS FSGLPLGPAR RPAPSYRTEP APGERWEAAR
AQRALEAALA AGLRDARYVG AEAGRLAREL CDLARVHLRE LSPPRYKLVC SVVLGPRAGQ
GVHVPSRALW DTACDGLASA TVTNASLFAV ATVHGLYCE
