ID   DYLT5_MOUSE             Reviewed;         173 AA.
AC   Q9D5I4; Q80ZP4; Q9CVR8;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Dynein light chain Tctex-type 5;
DE   AltName: Full=Tctex1 domain-containing protein 1;
GN   Name=Dynlt5; Synonyms=Tctex1d1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBUNIT: Interacts with ZMYND10. {ECO:0000250|UniProtKB:Q8N7M0}.
CC   -!- SIMILARITY: Belongs to the dynein light chain Tctex-type family.
CC       {ECO:0000305}.
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DR   EMBL; AK006804; BAB24749.3; -; mRNA.
DR   EMBL; AK015315; BAB29793.1; -; mRNA.
DR   EMBL; AL732543; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC048635; AAH48635.1; ALT_TERM; mRNA.
DR   EMBL; BC099549; AAH99549.1; -; mRNA.
DR   EMBL; BC132398; AAI32399.1; -; mRNA.
DR   EMBL; BC132400; AAI32401.1; -; mRNA.
DR   CCDS; CCDS18405.1; -.
DR   RefSeq; NP_001157239.1; NM_001163767.1.
DR   RefSeq; NP_080376.1; NM_026100.3.
DR   AlphaFoldDB; Q9D5I4; -.
DR   SMR; Q9D5I4; -.
DR   IntAct; Q9D5I4; 1.
DR   STRING; 10090.ENSMUSP00000112019; -.
DR   iPTMnet; Q9D5I4; -.
DR   PhosphoSitePlus; Q9D5I4; -.
DR   PaxDb; Q9D5I4; -.
DR   PRIDE; Q9D5I4; -.
DR   ProteomicsDB; 263141; -.
DR   Antibodypedia; 33388; 42 antibodies from 20 providers.
DR   DNASU; 67344; -.
DR   Ensembl; ENSMUST00000030248; ENSMUSP00000030248; ENSMUSG00000028523.
DR   Ensembl; ENSMUST00000116317; ENSMUSP00000112019; ENSMUSG00000028523.
DR   Ensembl; ENSMUST00000169211; ENSMUSP00000128228; ENSMUSG00000028523.
DR   GeneID; 67344; -.
DR   KEGG; mmu:67344; -.
DR   UCSC; uc008twx.2; mouse.
DR   CTD; 200132; -.
DR   MGI; MGI:1914594; Dynlt5.
DR   VEuPathDB; HostDB:ENSMUSG00000028523; -.
DR   eggNOG; KOG4108; Eukaryota.
DR   GeneTree; ENSGT00940000160185; -.
DR   HOGENOM; CLU_097204_4_0_1; -.
DR   InParanoid; Q9D5I4; -.
DR   OMA; SYMDEPS; -.
DR   PhylomeDB; Q9D5I4; -.
DR   TreeFam; TF313904; -.
DR   Reactome; R-MMU-5620924; Intraflagellar transport.
DR   BioGRID-ORCS; 67344; 1 hit in 69 CRISPR screens.
DR   ChiTaRS; Tctex1d1; mouse.
DR   PRO; PR:Q9D5I4; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; Q9D5I4; protein.
DR   Bgee; ENSMUSG00000028523; Expressed in morula and 43 other tissues.
DR   ExpressionAtlas; Q9D5I4; baseline and differential.
DR   Genevisible; Q9D5I4; MM.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005868; C:cytoplasmic dynein complex; IBA:GO_Central.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IBA:GO_Central.
DR   GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR   Gene3D; 3.30.1140.40; -; 1.
DR   InterPro; IPR005334; Tctex-1-like.
DR   InterPro; IPR038586; Tctex-1-like_sf.
DR   PANTHER; PTHR21255; PTHR21255; 1.
DR   Pfam; PF03645; Tctex-1; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..173
FT                   /note="Dynein light chain Tctex-type 5"
FT                   /id="PRO_0000284886"
FT   REGION          1..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..42
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   173 AA;  19680 MW;  2DB9AC6775A9C9EB CRC64;
     MAQTHGSKQQ AQRLEQGAES LRHGAQAQSR ENNVSLSTVS HADEPSQRDE SSRLTVRMEN
     TYQLGPTKPF PVATVNHILE DVLTTYLQEA QYDPEFCRQM TKTISEVIKT QVKELVIPRY
     KLIVIVYIGQ RDDQSIVIGS RCLWNPKSDT VSSYTFKNST FFALANVYAV YFE