DYM_DROME
ID DYM_DROME Reviewed; 699 AA.
AC Q7KNA0;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Dymeclin;
GN ORFNames=CG8230;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=10731138; DOI=10.1126/science.287.5461.2222;
RA Rubin G.M., Hong L., Brokstein P., Evans-Holm M., Frise E., Stapleton M.,
RA Harvey D.A.;
RT "A Drosophila complementary DNA resource.";
RL Science 287:2222-2224(2000).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-346, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=17372656; DOI=10.1039/b617545g;
RA Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A.,
RA Eng J.K., Aebersold R., Tao W.A.;
RT "An integrated chemical, mass spectrometric and computational strategy for
RT (quantitative) phosphoproteomics: application to Drosophila melanogaster
RT Kc167 cells.";
RL Mol. Biosyst. 3:275-286(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-346, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- SIMILARITY: Belongs to the dymeclin family. {ECO:0000305}.
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DR EMBL; AE013599; AAF59014.1; -; Genomic_DNA.
DR EMBL; AF132149; AAD34737.1; -; mRNA.
DR RefSeq; NP_610431.1; NM_136587.3.
DR AlphaFoldDB; Q7KNA0; -.
DR BioGRID; 61735; 8.
DR IntAct; Q7KNA0; 10.
DR STRING; 7227.FBpp0087755; -.
DR iPTMnet; Q7KNA0; -.
DR PaxDb; Q7KNA0; -.
DR PRIDE; Q7KNA0; -.
DR DNASU; 35897; -.
DR EnsemblMetazoa; FBtr0088674; FBpp0087755; FBgn0027607.
DR GeneID; 35897; -.
DR KEGG; dme:Dmel_CG8230; -.
DR UCSC; CG8230-RA; d. melanogaster.
DR FlyBase; FBgn0027607; CG8230.
DR VEuPathDB; VectorBase:FBgn0027607; -.
DR eggNOG; KOG2225; Eukaryota.
DR GeneTree; ENSGT00390000008772; -.
DR HOGENOM; CLU_013309_2_0_1; -.
DR InParanoid; Q7KNA0; -.
DR OMA; WNGLLNY; -.
DR OrthoDB; 982213at2759; -.
DR PhylomeDB; Q7KNA0; -.
DR BioGRID-ORCS; 35897; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 35897; -.
DR PRO; PR:Q7KNA0; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0027607; Expressed in spermathecum and 43 other tissues.
DR Genevisible; Q7KNA0; DM.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR InterPro; IPR019142; Dymeclin.
DR PANTHER; PTHR12895; PTHR12895; 1.
PE 1: Evidence at protein level;
KW Lipoprotein; Myristate; Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..699
FT /note="Dymeclin"
FT /id="PRO_0000348215"
FT MOD_RES 346
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:17372656,
FT ECO:0000269|PubMed:18327897"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 699 AA; 79125 MW; 3C73F8499D2F3E55 CRC64;
MGINVSRTAD LGSNQWLQRF VGRQHIAHDD EAFWNGLLNY NIVLPENSQD QLNLDSRLEA
LCQSFIGNNL KTGNFGSLVT VFLEKTSELL SLSDQESNMH VWQTFNALFI IRSLVKYINE
TGSEFQLLQH FEAMPNAELL QAALEQQQQT PAESATIAME ATEQSAAAAV PVIVDGSKFE
TFIDALVNLI VVIPVKEFTY HLHLEAVNML ITLLSVHLFA QQPTDKSIVF RTVFKCQHAN
VLMSALLHFV ARIVEVPHTM FGSSSAGSFV FGIAESLLSI FTFRKQPDIL KAGQAAGGGE
LSQRFRTHYP LANQSLLLIL ILTNHCTAQD NAYRTSLFSC ADSKDSPKQG AVSFQIDFSA
VYETLCTIVT IDQATLLLYL LLHRNERFYR FVMQQQDLEQ LVIPILQTLY NAPDSNSHHI
YMSLIVLLIL SEDEGFNKNV HTIMLKNITW YTERTISEIS LGGILILIVI RTIQYNMLKM
RDKYLHTNCL AALANMSGHF RALHPYVAQR LVSLFETLAR KHTRLDAQLK EPADSAVFVN
VSTTPEDMLQ DLSVLEEVLR MVLEILNSCL TNQLVYCPNL VYTLLYKRSV FEGFRSHHAF
QDVIQNIDMV VGFFSSRLQR VQEQRGELGV NEVLEVISKG ASQWSSDRLR KFPDLKFKYV
EEDAPEEFFI PYVWTLVCKY GCVHFSSESI KSVTTDIAC
