ID   DYM_PONAB               Reviewed;         669 AA.
AC   Q5RAW5;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Dymeclin;
GN   Name=DYM;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Necessary for correct organization of Golgi apparatus.
CC       Involved in bone development. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with GOLM1 and PPIB. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus {ECO:0000250}.
CC       Membrane {ECO:0000250|UniProtKB:Q7RTS9}; Lipid-anchor
CC       {ECO:0000250|UniProtKB:Q7RTS9}. Note=Sequence analysis programs predict
CC       1 transmembrane region. However, it has been shown in human that it is
CC       not a stably anchored transmembrane protein but it weakly associates
CC       with the Golgi apparatus and shuttles between the Golgi and the cytosol
CC       (By similarity). {ECO:0000250}.
CC   -!- PTM: Myristoylated in vitro; myristoylation is not essential for
CC       protein targeting to Golgi compartment. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dymeclin family. {ECO:0000305}.
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DR   EMBL; CR858896; CAH91095.1; -; mRNA.
DR   RefSeq; NP_001127375.1; NM_001133903.1.
DR   AlphaFoldDB; Q5RAW5; -.
DR   STRING; 9601.ENSPPYP00000010279; -.
DR   GeneID; 100174440; -.
DR   KEGG; pon:100174440; -.
DR   CTD; 54808; -.
DR   eggNOG; KOG2225; Eukaryota.
DR   InParanoid; Q5RAW5; -.
DR   OrthoDB; 982213at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0060348; P:bone development; ISS:UniProtKB.
DR   GO; GO:0007030; P:Golgi organization; ISS:UniProtKB.
DR   InterPro; IPR019142; Dymeclin.
DR   PANTHER; PTHR12895; PTHR12895; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Golgi apparatus; Lipoprotein; Membrane; Myristate;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q7RTS9"
FT   CHAIN           2..669
FT                   /note="Dymeclin"
FT                   /id="PRO_0000086885"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7RTS9"
SQ   SEQUENCE   669 AA;  76027 MW;  EE55118F323BA5BF CRC64;
     MGSNSSRIGD LPKNQYLKKL SGTESISEND PFWNQLLSFS FPAPTSSTEL KLLEEATISV
     CRSLVENNPR TGNLGALIKV FLSRTKELKL SAECQNHIFI WQTHNALFII CCLLKVFICQ
     MSEEELQLHF TYEEKSPGNY SSDSEDLLEE LLCCLMQLIT DIPLLDITYE ISVEAISTMV
     VFLSCQLFHK EVLRQSISHK YLMRGPCLPY TSKLVKTLLY NFIRQEKPPP PGAHVFPQQS
     DGGGLLYGLA SGVATGLWTV FTLGGVGSKV AASPELSSPL ANQSLLLLLV LANLTDASDA
     PNPYRQAIMS FKNTQDSSPF PPLIPHAFQI NFNSLYTALC EQQTSDQATL LLYTLLHQNS
     NIRTYMLART DMENLVLPIL EILYHVEERN SHHVYMALII LLILTEDDGF NRSIHEVILK
     NITWYSERVL TEISLGSLLI LVVIRTIQYN MTRTRDKYLH TNCLAALANM SAQFRSLHQY
     AAQRIISLFS LLSKKHNKVL EQATQSLRGS LSSNDVPLPD YAQDLNVIEE VIRMMLEIIN
     SCLTNSLHHN PNLVYALLYK RDLFEQFRTH PSFQDIMQNI DLVITFFSSR LLQAGAELSV
     ERVLEIIKQG VVALPKDRLK KFPELKFKYV EEEQPEEFFI PYVWSLVYNS AVGLYWNPQD
     IQLFTMDSD