ID   DYM_RAT                 Reviewed;         674 AA.
AC   B4F766;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Dymeclin;
GN   Name=Dym;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Necessary for correct organization of Golgi apparatus.
CC       Involved in bone development. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with GOLM1 and PPIB. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus {ECO:0000250}.
CC       Membrane {ECO:0000250|UniProtKB:Q7RTS9}; Lipid-anchor
CC       {ECO:0000250|UniProtKB:Q7RTS9}. Note=Sequence analysis programs predict
CC       1 transmembrane region. However, it has been shown in human that it is
CC       not a stably anchored transmembrane protein but it weakly associates
CC       with the Golgi apparatus and shuttles between the Golgi and the cytosol
CC       (By similarity). {ECO:0000250}.
CC   -!- PTM: Myristoylated in vitro; myristoylation is not essential for
CC       protein targeting to Golgi compartment. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dymeclin family. {ECO:0000305}.
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DR   EMBL; BC168151; AAI68151.1; -; mRNA.
DR   RefSeq; XP_017456369.1; XM_017600880.1.
DR   AlphaFoldDB; B4F766; -.
DR   STRING; 10116.ENSRNOP00000024950; -.
DR   PaxDb; B4F766; -.
DR   PeptideAtlas; B4F766; -.
DR   PRIDE; B4F766; -.
DR   Ensembl; ENSRNOT00000024950; ENSRNOP00000024950; ENSRNOG00000018425.
DR   GeneID; 291433; -.
DR   CTD; 54808; -.
DR   RGD; 1309111; Dym.
DR   eggNOG; KOG2225; Eukaryota.
DR   GeneTree; ENSGT00390000008772; -.
DR   HOGENOM; CLU_013309_2_0_1; -.
DR   InParanoid; B4F766; -.
DR   OrthoDB; 982213at2759; -.
DR   PhylomeDB; B4F766; -.
DR   TreeFam; TF314870; -.
DR   PRO; PR:B4F766; -.
DR   Proteomes; UP000002494; Chromosome 18.
DR   Genevisible; B4F766; RN.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019899; F:enzyme binding; ISO:RGD.
DR   GO; GO:0060348; P:bone development; ISS:UniProtKB.
DR   GO; GO:0007030; P:Golgi organization; ISS:UniProtKB.
DR   InterPro; IPR019142; Dymeclin.
DR   PANTHER; PTHR12895; PTHR12895; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Golgi apparatus; Lipoprotein; Membrane; Myristate;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q7RTS9"
FT   CHAIN           2..674
FT                   /note="Dymeclin"
FT                   /id="PRO_0000365012"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7RTS9"
SQ   SEQUENCE   674 AA;  76491 MW;  85691C69FDD44278 CRC64;
     MGSNSSKISD LPKNEYLKRL SGPEAISEND PFWNQLFSFS FSAPTSSTEL KLLEEATISV
     CKSLVENNPR TGNLAALTKV FLARTRELRL SAECQNHIFI WQTHNALFII CCLLKVFICE
     MSEEELQLHF TYEEKLPGTY TLCVLLGSDS EDLLEELLCS LIQLITDTPL LDITYEISVE
     AISAMIVFLS CQLFHKEVLR QSISHKYLMQ GPCLPYTSKL VKTLLYNFIR QEKPPPPGTH
     VFPQQSDGGG LLYGLASGVA TGLWTVFTLG GVGSKAASPE LTSPLANQSL LLLLVLVNLT
     DAPDIPNPYR QAVTSFKNTQ DSSPFPSSVP HTFQINFNSL YTTLCEQQTS DQATLLLYTL
     LHQNANVRTY MLARTDMENL VLPILEILYH VEERNSHHVY MALIILLILT EDDGFNRSIH
     EVILKNITWY SERVLTEISL GSLLILVVIR TIQYNMTRTR DKYLHTNCLA ALANMSAQFR
     SLHQYAAQRI ISLFSLLSKK HNKVLEQATQ SLRGSLSSSD VPLPDYAQDL SVIEEVIRMM
     LEIINSCLTN SLHHNPNLVY ALLYKRDLFE QFRTHPSFQD IMQNIDLVIS FFSSRLLQSG
     AELSVERVLE IIKQGVVALP KDRLKKFPEL KFKYVEEEQP EEFFIPYVWS LVYNSAVGLY
     WNPQDIQLFA MDSD