ID   DYM_XENLA               Reviewed;         669 AA.
AC   Q6DCP6;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Dymeclin;
GN   Name=dym;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Necessary for correct organization of Golgi apparatus.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus {ECO:0000250}.
CC       Note=Sequence analysis programs predict 3 transmembrane regions.
CC       However, it has been shown in human that it is not a stably anchored
CC       transmembrane protein but it weakly associates with the Golgi apparatus
CC       and shuttles between the Golgi and the cytosol (By similarity).
CC       {ECO:0000250}.
CC   -!- PTM: Myristoylated in vitro; myristoylation is not essential for
CC       protein targeting to Golgi compartment. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dymeclin family. {ECO:0000305}.
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DR   EMBL; BC077956; AAH77956.1; -; mRNA.
DR   RefSeq; NP_001087057.1; NM_001093588.1.
DR   AlphaFoldDB; Q6DCP6; -.
DR   DNASU; 446892; -.
DR   GeneID; 446892; -.
DR   KEGG; xla:446892; -.
DR   CTD; 446892; -.
DR   Xenbase; XB-GENE-5729316; dym.L.
DR   OrthoDB; 982213at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 446892; Expressed in testis and 19 other tissues.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019142; Dymeclin.
DR   PANTHER; PTHR12895; PTHR12895; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Golgi apparatus; Lipoprotein; Myristate; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..669
FT                   /note="Dymeclin"
FT                   /id="PRO_0000365013"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   669 AA;  76120 MW;  80CD0BF40514AB61 CRC64;
     MGANSSTIKE LSENEYLKKL SGMDSISENE PFWNQLLSFT LSTPTNSADS KLLEEGTLSI
     CKSLIENNPR TGNLGALIRV FLSRTKELKI SAECQNQLFI WQAHNALFII CCLIKVFTSQ
     VSEEELLLHF TYRATDPGNY EADTEDLFEE LLFCLIQLIV EIPLLDLTYS ILLEAVTALI
     VLLSYQLFHK DILHESPIHK HLMNGRCLPY TSRLVKTLLY NFIRQEKSPP PGSHIFPQQQ
     DGGGLLYGLA SGVASGIWTV LTLGGVGSKP TPQQEQSSPL ANQSLLLLLV LSNLTDSPDC
     PNPFRQSVTF FKNTQDSSVS PTPNPHSFQI NFNSLYTSLC EQQKSDQATL LLYTLLHQNS
     NVRTYVLARS DMENLVLPIL EILYHVEERN SHHVYMALII LLILTEDDGF NRSIHEVILK
     NITWYTERVL TEISLGSLLI LVVIRTIQFN MTRTRDKYLH TNCLAALANM SAQFRSLHQY
     AAQRIISLFS LLSKKHNKVL EQATQSLRGS LGSDESPLPD YAQDLNVIEE VIRMMLEIIN
     SCLTNSLHHN PNMVYALLYK RELFEQFRSH PSFQDIMQNI DMVISFFSLR LEQAGADLSV
     ERVLEVIKQG AVALPKDRLR KFPELKFKYV EEEQPEEFFI PYVWSLVYHS GVGLYWNPQD
     VQLFTMDSG