ID   ADIG_BOVIN              Reviewed;          81 AA.
AC   Q2EMW0; A7MB91;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Adipogenin;
GN   Name=ADIG {ECO:0000250|UniProtKB:Q0VDE8};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:ABD14393.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RA   Hong Y.H., Ogihara Y., Hishikawa D., Gotoh C., Iga T., Suzuki Y.,
RA   Song S.H., Nakajima K., Kozakai T., Sasaki S., Roh S.G.;
RT   "Molecular cloning and expression analysis of cDNA encoding bovine
RT   adipogenin.";
RL   Anim. Sci. J. 77:613-619(2006).
RN   [2] {ECO:0000312|EMBL:AAI20475.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus {ECO:0000312|EMBL:AAI20475.1};
RC   TISSUE=Liver {ECO:0000312|EMBL:AAI20475.1};
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in stimulating adipocyte differentiation and
CC       development. {ECO:0000269|Ref.1}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}. Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in subcutaneous, perirenal and
CC       mesecentric adipose tissue. {ECO:0000269|Ref.1}.
CC   -!- INDUCTION: Up-regulated during adipose differentiation of four
CC       different kinds of preadipocytes prepared from subcutaneous, perirenal,
CC       mesenteric and parametrial adipose tissues. {ECO:0000269|Ref.1}.
CC   -!- SIMILARITY: Belongs to the adipogenin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DQ372929; ABD14393.1; -; mRNA.
DR   EMBL; BC120474; AAI20475.1; -; mRNA.
DR   EMBL; BC151417; AAI51418.1; -; mRNA.
DR   RefSeq; NP_001107192.1; NM_001113720.2.
DR   RefSeq; XP_015329625.1; XM_015474139.1.
DR   AlphaFoldDB; Q2EMW0; -.
DR   SMR; Q2EMW0; -.
DR   STRING; 9913.ENSBTAP00000041676; -.
DR   PaxDb; Q2EMW0; -.
DR   Ensembl; ENSBTAT00000044163; ENSBTAP00000041676; ENSBTAG00000031188.
DR   GeneID; 510677; -.
DR   KEGG; bta:510677; -.
DR   CTD; 149685; -.
DR   VEuPathDB; HostDB:ENSBTAG00000031188; -.
DR   VGNC; VGNC:25676; ADIG.
DR   eggNOG; ENOG502SXJP; Eukaryota.
DR   GeneTree; ENSGT00390000018723; -.
DR   HOGENOM; CLU_2605436_0_0_1; -.
DR   InParanoid; Q2EMW0; -.
DR   OMA; SDLCFNW; -.
DR   OrthoDB; 1564414at2759; -.
DR   Proteomes; UP000009136; Chromosome 13.
DR   Bgee; ENSBTAG00000031188; Expressed in subcutaneous adipose tissue and 52 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:HGNC-UCL.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005811; C:lipid droplet; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISS:HGNC-UCL.
DR   GO; GO:0050873; P:brown fat cell differentiation; ISS:HGNC-UCL.
DR   GO; GO:0045600; P:positive regulation of fat cell differentiation; ISS:HGNC-UCL.
DR   GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR   GO; GO:0050872; P:white fat cell differentiation; ISS:HGNC-UCL.
DR   InterPro; IPR027938; Adipogenin.
DR   PANTHER; PTHR38499; PTHR38499; 1.
DR   Pfam; PF15202; Adipogenin; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..81
FT                   /note="Adipogenin"
FT                   /id="PRO_0000296374"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   81 AA;  9696 MW;  0E7378CFC69B4C5A CRC64;
     MKYPLVPLVN ELTFSFLVFW LCLPVALLLF LLIIWLRFLL SQDSEENDSD VCLDWEPWSK
     NPDEFCQEEM LHSQEEERPC C