ID   DYN3_KLULA              Reviewed;         370 AA.
AC   Q6CX98;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Cytoplasmic dynein intermediate light chain DYN3;
DE            Short=Dynein protein 3;
GN   Name=DYN3; OrderedLocusNames=KLLA0A10087g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the cytoplasmic dynein which acts as a motor for
CC       the intracellular retrograde motility of vesicles and organelles along
CC       microtubules. May play an important role in the proper orientation of
CC       the mitotic spindle into the budding daughter cell yeast. Probably
CC       required for normal progression of the cell cycle (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: The cytoplasmic dynein is composed of at least two heavy
CC       chains and a number of intermediate and light chains. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dynein light intermediate chain DYN3 family.
CC       {ECO:0000305}.
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DR   EMBL; CR382121; CAH03029.1; -; Genomic_DNA.
DR   RefSeq; XP_451441.1; XM_451441.1.
DR   AlphaFoldDB; Q6CX98; -.
DR   STRING; 28985.XP_451441.1; -.
DR   PRIDE; Q6CX98; -.
DR   EnsemblFungi; CAH03029; CAH03029; KLLA0_A10087g.
DR   GeneID; 2896557; -.
DR   KEGG; kla:KLLA0_A10087g; -.
DR   eggNOG; ENOG502S4QG; Eukaryota.
DR   HOGENOM; CLU_748153_0_0_1; -.
DR   InParanoid; Q6CX98; -.
DR   OMA; WINEDQS; -.
DR   Proteomes; UP000000598; Chromosome A.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Cytoplasm; Cytoskeleton; Dynein; Microtubule; Motor protein;
KW   Reference proteome.
FT   CHAIN           1..370
FT                   /note="Cytoplasmic dynein intermediate light chain DYN3"
FT                   /id="PRO_0000292445"
SQ   SEQUENCE   370 AA;  41556 MW;  69D15BBAE51DCA10 CRC64;
     MATKLEAFIN DLRLQCETND TTKYVSIVLF CEKETTLKLF FQYIDGIDTN SEPKLAVLSP
     TLSPVGYYTK EITTEDGWQV ILNITCIPPP WKSSSIDLLP SILKSDPEKS SKRFVLLLDW
     INEDQSYWLE DIEGLFVQLK QVSPETKAAG SVMMLHSDYC KHLENTHTKW SSTAIDFMHQ
     SLRTLALHLK ISLYSDLKNS VLAAKSAVGV PLSTEEQKSL IDMVNLENVN VTYGSDSLNK
     IAMIDENFPL SVYKDNLSTL KHDFSDVIPE IKPRNMGSCA ITEPIKPLPD LQSLIPDVQG
     QLSHLYELQR KNSSLKRVTN QPAVVQDIGQ DNTMALNDIA SDNNHLQHVP DDDSALDSLV
     HGIVQRHQIS