ADIG_HUMAN
ID ADIG_HUMAN Reviewed; 80 AA.
AC Q0VDE8;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Adipogenin;
GN Name=ADIG {ECO:0000312|EMBL:AAI19706.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [2] {ECO:0000312|EMBL:AAI19706.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plays a role in stimulating adipocyte differentiation and
CC development. {ECO:0000250|UniProtKB:Q8R400}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the adipogenin family. {ECO:0000305}.
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DR EMBL; AL035419; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC119704; AAI19705.1; -; mRNA.
DR EMBL; BC119705; AAI19706.1; -; mRNA.
DR CCDS; CCDS54461.1; -.
DR RefSeq; NP_001018092.1; NM_001018082.2.
DR AlphaFoldDB; Q0VDE8; -.
DR SMR; Q0VDE8; -.
DR STRING; 9606.ENSP00000440331; -.
DR TCDB; 9.B.434.1.1; the adipogenin (adig) family.
DR PhosphoSitePlus; Q0VDE8; -.
DR BioMuta; ADIG; -.
DR DMDM; 156630981; -.
DR PaxDb; Q0VDE8; -.
DR PeptideAtlas; Q0VDE8; -.
DR PRIDE; Q0VDE8; -.
DR ProteomicsDB; 58824; -.
DR Antibodypedia; 51583; 12 antibodies from 8 providers.
DR DNASU; 149685; -.
DR Ensembl; ENST00000470147.5; ENSP00000434385.1; ENSG00000182035.13.
DR Ensembl; ENST00000537425.3; ENSP00000440331.2; ENSG00000182035.13.
DR GeneID; 149685; -.
DR MANE-Select; ENST00000537425.3; ENSP00000440331.2; NM_001393816.1; NP_001380745.1.
DR UCSC; uc002xjb.1; human.
DR CTD; 149685; -.
DR DisGeNET; 149685; -.
DR GeneCards; ADIG; -.
DR HGNC; HGNC:28606; ADIG.
DR HPA; ENSG00000182035; Tissue enriched (testis).
DR MIM; 611396; gene.
DR neXtProt; NX_Q0VDE8; -.
DR OpenTargets; ENSG00000182035; -.
DR PharmGKB; PA162375689; -.
DR VEuPathDB; HostDB:ENSG00000182035; -.
DR eggNOG; ENOG502SXJP; Eukaryota.
DR GeneTree; ENSGT00390000018723; -.
DR HOGENOM; CLU_2605436_0_0_1; -.
DR InParanoid; Q0VDE8; -.
DR OMA; SDLCFNW; -.
DR OrthoDB; 1564414at2759; -.
DR PhylomeDB; Q0VDE8; -.
DR PathwayCommons; Q0VDE8; -.
DR SignaLink; Q0VDE8; -.
DR BioGRID-ORCS; 149685; 12 hits in 1063 CRISPR screens.
DR GenomeRNAi; 149685; -.
DR Pharos; Q0VDE8; Tdark.
DR PRO; PR:Q0VDE8; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q0VDE8; protein.
DR Bgee; ENSG00000182035; Expressed in right testis and 67 other tissues.
DR ExpressionAtlas; Q0VDE8; baseline and differential.
DR Genevisible; Q0VDE8; HS.
DR GO; GO:0005737; C:cytoplasm; ISS:HGNC-UCL.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005811; C:lipid droplet; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISS:HGNC-UCL.
DR GO; GO:0050873; P:brown fat cell differentiation; ISS:HGNC-UCL.
DR GO; GO:0045600; P:positive regulation of fat cell differentiation; ISS:HGNC-UCL.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR GO; GO:0050872; P:white fat cell differentiation; ISS:HGNC-UCL.
DR InterPro; IPR027938; Adipogenin.
DR PANTHER; PTHR38499; PTHR38499; 1.
DR Pfam; PF15202; Adipogenin; 1.
PE 3: Inferred from homology;
KW Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..80
FT /note="Adipogenin"
FT /id="PRO_0000296375"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 80 AA; 9465 MW; 7DC102D170BBF86F CRC64;
MKYPLMPLVN DLTFSFLVFW FCLPVGLLLL LIIWLRFLLS QDSEENDSSV CLDWEPWSKG
PAEFCWKGTL HGQEKERPCW
