ID   ADIPA_XENLA             Reviewed;         554 AA.
AC   Q6NRK1;
DT   19-FEB-2014, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Afadin- and alpha-actinin-binding protein A;
DE            Short=ADIP-A;
DE   AltName: Full=Afadin DIL domain-interacting protein A;
DE   AltName: Full=SSX2-interacting protein A;
DE            Short=XSSX2IP;
GN   Name=ssx2ip-a; Synonyms=ssx2ip;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, MICROTUBULE-BINDING, AND DEVELOPMENTAL
RP   STAGE.
RX   PubMed=23816619; DOI=10.1083/jcb.201302122;
RA   Barenz F., Inoue D., Yokoyama H., Tegha-Dunghu J., Freiss S., Draeger S.,
RA   Mayilo D., Cado I., Merker S., Klinger M., Hoeckendorf B., Pilz S.,
RA   Hupfeld K., Steinbeisser H., Lorenz H., Ruppert T., Wittbrodt J.,
RA   Gruss O.J.;
RT   "The centriolar satellite protein SSX2IP promotes centrosome maturation.";
RL   J. Cell Biol. 202:81-95(2013).
RN   [3]
RP   INTERACTION WITH WRAP73.
RX   PubMed=26545777; DOI=10.1016/j.bbrc.2015.10.169;
RA   Hori A., Morand A., Ikebe C., Frith D., Snijders A.P., Toda T.;
RT   "The conserved Wdr8-hMsd1/SSX2IP complex localises to the centrosome and
RT   ensures proper spindle length and orientation.";
RL   Biochem. Biophys. Res. Commun. 468:39-45(2015).
CC   -!- FUNCTION: Belongs to an adhesion system, which plays a role in the
CC       organization of homotypic, interneuronal and heterotypic cell-cell
CC       adherens junctions (AJs). Involved in cell movement (By similarity).
CC       Acts as a centrosome maturation factor, probably by maintaining the
CC       integrity of the pericentriolar material and proper microtubule
CC       nucleation at mitotic spindle poles. The function seems to implicate at
CC       least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as
CC       regulator of spindle anchoring at the mitotic centrosome.
CC       {ECO:0000250|UniProtKB:Q8VC66, ECO:0000250|UniProtKB:Q9Y2D8,
CC       ECO:0000269|PubMed:23816619}.
CC   -!- SUBUNIT: Interacts with WRAP73. {ECO:0000305|PubMed:26545777}.
CC   -!- SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000250}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,
CC       centriolar satellite {ECO:0000269|PubMed:23816619}.
CC   -!- DEVELOPMENTAL STAGE: Expressed at M-phase onset and accumulates at
CC       microtubule minus ends. {ECO:0000269|PubMed:23816619}.
CC   -!- SIMILARITY: Belongs to the ADIP family. {ECO:0000305}.
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DR   EMBL; BC070749; AAH70749.1; -; mRNA.
DR   RefSeq; NP_001084793.1; NM_001091324.1.
DR   AlphaFoldDB; Q6NRK1; -.
DR   SMR; Q6NRK1; -.
DR   DNASU; 431833; -.
DR   GeneID; 431833; -.
DR   KEGG; xla:431833; -.
DR   CTD; 431833; -.
DR   Xenbase; XB-GENE-6077817; ssx2ip.S.
DR   OrthoDB; 753479at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 431833; Expressed in egg cell and 16 other tissues.
DR   GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0034451; C:centriolar satellite; IDA:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0051011; F:microtubule minus-end binding; IDA:UniProtKB.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0007098; P:centrosome cycle; IMP:UniProtKB.
DR   InterPro; IPR021622; Afadin/alpha-actinin-bd.
DR   Pfam; PF11559; ADIP; 1.
PE   1: Evidence at protein level;
KW   Cell adhesion; Cell junction; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Microtubule; Reference proteome.
FT   CHAIN           1..554
FT                   /note="Afadin- and alpha-actinin-binding protein A"
FT                   /id="PRO_0000425547"
FT   REGION          508..528
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          122..287
FT                   /evidence="ECO:0000255"
FT   COILED          359..449
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   554 AA;  64680 MW;  439EA3AEE3C2C98D CRC64;
     MGDRRTISLP ESDKILQYCS EIRMSPTSLL PSPSHSVANN LSGSVYTFCT EDNLEQCITY
     IDQELRTIGF PTVQAVSKNG EGRKLHLVSI INCIYELLQR NSQTMRSNEE VETQLLKING
     DLEYLQSIHQ RQKDQLEATK RENCALQERD RQMQCKNRNL LQLLKNEKEE VQKLQNIIAS
     RSTQYNHSVK RKEREYNKLK ERLYQLVMDK RDKKISIDVL NYVGRADGKR SSWRTGKTDA
     KNEEEMYKVL LNDYEQRQKQ LMVENVELKK VLQQMKKEMI SIVSQRKTKE KLEDSTGTVT
     SDIEEEIADS SKENLSELSC EAVREQLISS IRQQWRILKS HMEKLDNQAC LVNVPTPDEN
     GLIARAEHEQ ELDKLISEIQ QCKETIRSQQ QLLKQQLSVP RDDDTSKLLQ DCYLLEDKER
     LQEEWKLFNA QKKNFEKERR NFTEAAIRLG HEKKVFEEDR AAWLKHQFLN MTVFSDHKNL
     EERKVPGVHF SSEQDNCRLH SRPHDKVLAS SGDYSRRPSK ALPITSSSKH SLTQIESISW
     RDSSISPNDT DFLN