ID   ADIPL_DANRE             Reviewed;         318 AA.
AC   A1A5X5;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Adipolin;
DE   AltName: Full=Adipose-derived insulin-sensitizing factor;
DE   AltName: Full=Complement C1q tumor necrosis factor-related protein 12;
DE   Flags: Precursor;
GN   Name=c1qtnf12; Synonyms=c1qdc2, fam132a; ORFNames=zgc:158358;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Insulin-sensitizing adipocyte-secreted protein (adipokine)
CC       that regulates glucose metabolism in liver and adipose tissue.
CC       {ECO:0000250|UniProtKB:Q8R2Z0}.
CC   -!- SUBUNIT: Homomultimer; disulfide-linked.
CC       {ECO:0000250|UniProtKB:Q8R2Z0}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8R2Z0}.
CC   -!- SIMILARITY: Belongs to the adipolin/erythroferrone family.
CC       {ECO:0000305}.
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DR   EMBL; BC128849; AAI28850.1; -; mRNA.
DR   RefSeq; NP_001073547.1; NM_001080078.1.
DR   AlphaFoldDB; A1A5X5; -.
DR   STRING; 7955.ENSDARP00000094804; -.
DR   PaxDb; A1A5X5; -.
DR   PRIDE; A1A5X5; -.
DR   Ensembl; ENSDART00000104029; ENSDARP00000094804; ENSDARG00000070681.
DR   GeneID; 790933; -.
DR   KEGG; dre:790933; -.
DR   CTD; 388581; -.
DR   ZFIN; ZDB-GENE-061215-120; c1qtnf12.
DR   eggNOG; ENOG502QQVR; Eukaryota.
DR   GeneTree; ENSGT00940000160300; -.
DR   HOGENOM; CLU_057344_1_0_1; -.
DR   InParanoid; A1A5X5; -.
DR   OMA; RCRGRDK; -.
DR   OrthoDB; 1462460at2759; -.
DR   PhylomeDB; A1A5X5; -.
DR   TreeFam; TF331282; -.
DR   PRO; PR:A1A5X5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 23.
DR   Bgee; ENSDARG00000070681; Expressed in swim bladder and 14 other tissues.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; ISS:UniProtKB.
DR   GO; GO:0046324; P:regulation of glucose import; ISS:UniProtKB.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:InterPro.
DR   Gene3D; 2.60.120.40; -; 1.
DR   InterPro; IPR001073; C1q_dom.
DR   InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR   InterPro; IPR009143; Wnt6.
DR   Pfam; PF00386; C1q; 1.
DR   PRINTS; PR01845; WNT6PROTEIN.
DR   SUPFAM; SSF49842; SSF49842; 1.
DR   PROSITE; PS50871; C1Q; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..318
FT                   /note="Adipolin"
FT                   /id="PRO_0000284356"
FT   DOMAIN          162..318
FT                   /note="C1q"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00368"
FT   REGION          45..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        94..111
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        44
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   318 AA;  34826 MW;  9E86170DCF2DCCBB CRC64;
     MRCWVLAVVT AVLWSQCIPL GWAEGRKVPK RLKEGAPQHT EAFNTTLSNS EELDGSPKQV
     GENQRVDPLG SWMDFVKRPV GNFPGKCRKR KRPLPGPPGP PGPPGPQGPP GAPGAEVTQE
     VLLREFKEMI KEATERRAAV DRPSEPSQLP TALITLEGMT SYRRIEEAFH CKLKGPVVVD
     KKTLAELQNF QTPPAKGAFL RGTGMDQSTG RFTAPVTGIY QFSANVHIDH TEVKRSKSQL
     RARDNVRVLI CIESLCHRYT SLEMIVGLES NSKIFTVSVH GLLELQAGQY TSIFVDNAAG
     ASITIQNGSD FMGMLLGV