ID   ADIPL_XENTR             Reviewed;         324 AA.
AC   A4IH36;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Adipolin;
DE   AltName: Full=Adipose-derived insulin-sensitizing factor;
DE   AltName: Full=Complement C1q tumor necrosis factor-related protein 12;
DE   Flags: Precursor;
GN   Name=c1qtnf12; Synonyms=ctrp12, fam132a;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Insulin-sensitizing adipocyte-secreted protein (adipokine)
CC       that regulates glucose metabolism in liver and adipose tissue.
CC       {ECO:0000250|UniProtKB:Q8R2Z0}.
CC   -!- SUBUNIT: Homomultimer; disulfide-linked.
CC       {ECO:0000250|UniProtKB:Q8R2Z0}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8R2Z0}.
CC   -!- SIMILARITY: Belongs to the adipolin/erythroferrone family.
CC       {ECO:0000305}.
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DR   EMBL; BC135357; AAI35358.1; -; mRNA.
DR   RefSeq; NP_001016365.2; NM_001016365.3.
DR   AlphaFoldDB; A4IH36; -.
DR   DNASU; 549119; -.
DR   Ensembl; ENSXETT00000002270; ENSXETP00000002270; ENSXETG00000001035.
DR   GeneID; 549119; -.
DR   KEGG; xtr:549119; -.
DR   CTD; 388581; -.
DR   Xenbase; XB-GENE-5726440; c1qtnf12.
DR   eggNOG; ENOG502QQVR; Eukaryota.
DR   InParanoid; A4IH36; -.
DR   OrthoDB; 1462460at2759; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000001035; Expressed in mesonephros and 1 other tissue.
DR   ExpressionAtlas; A4IH36; baseline.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; ISS:UniProtKB.
DR   GO; GO:0045721; P:negative regulation of gluconeogenesis; IBA:GO_Central.
DR   GO; GO:0046326; P:positive regulation of glucose import; IBA:GO_Central.
DR   GO; GO:0046628; P:positive regulation of insulin receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0046324; P:regulation of glucose import; ISS:UniProtKB.
DR   Gene3D; 2.60.120.40; -; 1.
DR   InterPro; IPR001073; C1q_dom.
DR   InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR   Pfam; PF00386; C1q; 1.
DR   SUPFAM; SSF49842; SSF49842; 1.
DR   PROSITE; PS50871; C1Q; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..324
FT                   /note="Adipolin"
FT                   /id="PRO_0000340249"
FT   DOMAIN          169..324
FT                   /note="C1q"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00368"
FT   REGION          28..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          83..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        102..119
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        43
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   324 AA;  35757 MW;  CD66C6073C3CF98C CRC64;
     MRCWVWLLVA IVLCQQLSVV RVLAAKKERK KGKDPHQFTE PFNVSLSNSE ELHETDKLSE
     TPDPGLPDAY TTWLGFVGRT DDGANSKKKC KGKDKKLRGL FGPPGPPGPQ GPPGPPGMPG
     AEVTYEVLLQ DFKQMLKEAT ERRLMSGDIP EHTSELPPIV LPVEDLSPYR RVDEGFHCRL
     KGQVIVDKKT LVELQNFQMP TAKGSFLRGS GLNLATGRFT ASVPGIYQFS AHVHIDHSEI
     KSKAQLRPRD NVRVLICIES MCHRYTSLEV IAGLESNSKI FTVHVQGLLQ LQVGQYTSIF
     VDNSAGAPIT VQNGSDFMGI LMGL